PTGES3

 

Full name: prostaglandin E synthase 3 Alias Symbol: p23|TEBP|cPGES
Type: protein-coding gene Cytoband: 12q13.3
Entrez ID: 10728 HGNC ID: HGNC:16049 Ensembl Gene: ENSG00000110958 OMIM ID: 607061
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of PTGES3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PTGES3 10728 200627_at 0.2728 0.4578
GSE20347 PTGES3 10728 200627_at 0.5862 0.0005
GSE23400 PTGES3 10728 200627_at 0.5630 0.0000
GSE26886 PTGES3 10728 200627_at -0.0169 0.9132
GSE29001 PTGES3 10728 200627_at 0.4247 0.3465
GSE38129 PTGES3 10728 200627_at 0.6520 0.0000
GSE45670 PTGES3 10728 200627_at 0.2484 0.0414
GSE53622 PTGES3 10728 44866 0.0555 0.2150
GSE53624 PTGES3 10728 72972 0.3317 0.0000
GSE63941 PTGES3 10728 200627_at 0.5917 0.0016
GSE77861 PTGES3 10728 200627_at 0.4058 0.0226
GSE97050 PTGES3 10728 A_32_P114896 0.2740 0.3187
SRP007169 PTGES3 10728 RNAseq 0.1086 0.7321
SRP008496 PTGES3 10728 RNAseq 0.1288 0.3843
SRP064894 PTGES3 10728 RNAseq 0.3148 0.0148
SRP133303 PTGES3 10728 RNAseq 0.7051 0.0000
SRP159526 PTGES3 10728 RNAseq 0.2339 0.3642
SRP193095 PTGES3 10728 RNAseq 0.0810 0.4170
SRP219564 PTGES3 10728 RNAseq 0.1709 0.5871
TCGA PTGES3 10728 RNAseq 0.1966 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PTGES3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PTGES3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PTGES3 10728 7 2 21
GSE20123 PTGES3 10728 7 1 22
GSE43470 PTGES3 10728 3 0 40
GSE46452 PTGES3 10728 8 1 50
GSE47630 PTGES3 10728 10 2 28
GSE54993 PTGES3 10728 0 5 65
GSE54994 PTGES3 10728 4 1 48
GSE60625 PTGES3 10728 0 0 11
GSE74703 PTGES3 10728 3 0 33
GSE74704 PTGES3 10728 4 1 15
TCGA PTGES3 10728 14 10 72

Total number of gains: 60; Total number of losses: 23; Total Number of normals: 405.  

 

Somatic mutations of PTGES3:

 

Generating mutation plots.

 

Highly correlated genes for PTGES3:

 

Showing top 20/1460 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PTGES3INO80E0.805165303
PTGES3BOD10.805042404
PTGES3SRP680.800797303
PTGES3USP370.799207303
PTGES3MAST10.797305303
PTGES3PRPF38A0.762621303
PTGES3WWP10.759115303
PTGES3COPS40.756428303
PTGES3ERCC80.750118303
PTGES3SYT170.748497303
PTGES3NACC10.743951303
PTGES3RPS19BP10.740147404
PTGES3CS0.738512303
PTGES3PHB0.734311706
PTGES3CTDSPL20.727041404
PTGES3RAVER10.719774403
PTGES3CCT40.718812010
PTGES3MBOAT10.717257303
PTGES3MIEN10.716802303
PTGES3RBMX0.716646303

For details and further investigation, click here