| Full name: dedicator of cytokinesis 8 | Alias Symbol: FLJ00026|FLJ00152|ZIR8|FLJ00346 | ||
| Type: protein-coding gene | Cytoband: 9p24.3 | ||
| Entrez ID: 81704 | HGNC ID: HGNC:19191 | Ensembl Gene: ENSG00000107099 | OMIM ID: 611432 |
| Drug and gene relationship at DGIdb | |||
Expression of DOCK8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DOCK8 | 81704 | 225502_at | -0.6925 | 0.2608 | |
| GSE26886 | DOCK8 | 81704 | 225502_at | -1.4052 | 0.0002 | |
| GSE45670 | DOCK8 | 81704 | 225502_at | -0.9602 | 0.0023 | |
| GSE53622 | DOCK8 | 81704 | 62826 | -0.9955 | 0.0000 | |
| GSE53624 | DOCK8 | 81704 | 62917 | -1.0887 | 0.0000 | |
| GSE63941 | DOCK8 | 81704 | 225502_at | -1.7617 | 0.0888 | |
| GSE77861 | DOCK8 | 81704 | 239027_at | -0.0831 | 0.6123 | |
| GSE97050 | DOCK8 | 81704 | A_23_P353888 | -0.3204 | 0.2565 | |
| SRP007169 | DOCK8 | 81704 | RNAseq | -0.4081 | 0.4400 | |
| SRP008496 | DOCK8 | 81704 | RNAseq | -0.7022 | 0.0169 | |
| SRP064894 | DOCK8 | 81704 | RNAseq | -0.3099 | 0.3112 | |
| SRP133303 | DOCK8 | 81704 | RNAseq | -0.4741 | 0.0566 | |
| SRP159526 | DOCK8 | 81704 | RNAseq | -1.3535 | 0.0601 | |
| SRP193095 | DOCK8 | 81704 | RNAseq | -0.5440 | 0.0130 | |
| SRP219564 | DOCK8 | 81704 | RNAseq | 0.1428 | 0.8139 | |
| TCGA | DOCK8 | 81704 | RNAseq | -0.3783 | 0.0012 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by DOCK8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DOCK8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DOCK8 | 81704 | 1 | 16 | 13 | |
| GSE20123 | DOCK8 | 81704 | 1 | 15 | 14 | |
| GSE43470 | DOCK8 | 81704 | 3 | 17 | 23 | |
| GSE46452 | DOCK8 | 81704 | 2 | 23 | 34 | |
| GSE47630 | DOCK8 | 81704 | 4 | 27 | 9 | |
| GSE54993 | DOCK8 | 81704 | 6 | 3 | 61 | |
| GSE54994 | DOCK8 | 81704 | 9 | 18 | 26 | |
| GSE60625 | DOCK8 | 81704 | 0 | 2 | 9 | |
| GSE74703 | DOCK8 | 81704 | 3 | 12 | 21 | |
| GSE74704 | DOCK8 | 81704 | 0 | 12 | 8 | |
| TCGA | DOCK8 | 81704 | 13 | 51 | 32 |
Total number of gains: 42; Total number of losses: 196; Total Number of normals: 250.
Somatic mutations of DOCK8:
Generating mutation plots.
Highly correlated genes for DOCK8:
Showing top 20/1182 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DOCK8 | XPC | 0.825204 | 3 | 0 | 3 |
| DOCK8 | KAT7 | 0.814379 | 3 | 0 | 3 |
| DOCK8 | GRHPR | 0.774289 | 3 | 0 | 3 |
| DOCK8 | CEP44 | 0.758483 | 3 | 0 | 3 |
| DOCK8 | CD1C | 0.750598 | 3 | 0 | 3 |
| DOCK8 | GIMAP5 | 0.749374 | 4 | 0 | 4 |
| DOCK8 | ARHGAP15 | 0.749371 | 4 | 0 | 4 |
| DOCK8 | HDHD2 | 0.742341 | 4 | 0 | 4 |
| DOCK8 | ZNF132 | 0.739806 | 3 | 0 | 3 |
| DOCK8 | EGLN1 | 0.737223 | 3 | 0 | 3 |
| DOCK8 | SETMAR | 0.735884 | 3 | 0 | 3 |
| DOCK8 | PPM1K | 0.731272 | 6 | 0 | 6 |
| DOCK8 | ABCD2 | 0.724045 | 4 | 0 | 4 |
| DOCK8 | ANKRD44 | 0.723453 | 7 | 0 | 6 |
| DOCK8 | ITGA9 | 0.723397 | 5 | 0 | 5 |
| DOCK8 | LSM14A | 0.722955 | 3 | 0 | 3 |
| DOCK8 | MAN1C1 | 0.720366 | 6 | 0 | 5 |
| DOCK8 | OGN | 0.719575 | 5 | 0 | 5 |
| DOCK8 | S100B | 0.718403 | 6 | 0 | 6 |
| DOCK8 | EIF4E3 | 0.71808 | 7 | 0 | 7 |
For details and further investigation, click here
