| Full name: WW domain containing transcription regulator 1 | Alias Symbol: TAZ|DKFZp586I1419 | ||
| Type: protein-coding gene | Cytoband: 3q25.1 | ||
| Entrez ID: 25937 | HGNC ID: HGNC:24042 | Ensembl Gene: ENSG00000018408 | OMIM ID: 607392 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
WWTR1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04390 | Hippo signaling pathway |
Expression of WWTR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WWTR1 | 25937 | 202133_at | -0.8841 | 0.1616 | |
| GSE20347 | WWTR1 | 25937 | 202133_at | -0.3311 | 0.1633 | |
| GSE23400 | WWTR1 | 25937 | 202134_s_at | -0.4045 | 0.0000 | |
| GSE26886 | WWTR1 | 25937 | 202133_at | 0.5489 | 0.0062 | |
| GSE29001 | WWTR1 | 25937 | 202133_at | -0.5298 | 0.2369 | |
| GSE38129 | WWTR1 | 25937 | 202133_at | -0.4197 | 0.1087 | |
| GSE45670 | WWTR1 | 25937 | 202133_at | -0.9261 | 0.0000 | |
| GSE53622 | WWTR1 | 25937 | 3822 | -0.5080 | 0.0000 | |
| GSE53624 | WWTR1 | 25937 | 3822 | -0.6315 | 0.0000 | |
| GSE63941 | WWTR1 | 25937 | 202133_at | -1.4854 | 0.0296 | |
| GSE77861 | WWTR1 | 25937 | 202133_at | 0.2702 | 0.4708 | |
| GSE97050 | WWTR1 | 25937 | A_23_P29769 | -0.5913 | 0.1655 | |
| SRP007169 | WWTR1 | 25937 | RNAseq | -1.0515 | 0.0031 | |
| SRP008496 | WWTR1 | 25937 | RNAseq | -0.4657 | 0.1939 | |
| SRP064894 | WWTR1 | 25937 | RNAseq | -0.3197 | 0.1574 | |
| SRP133303 | WWTR1 | 25937 | RNAseq | -0.1884 | 0.4787 | |
| SRP159526 | WWTR1 | 25937 | RNAseq | 0.4004 | 0.1371 | |
| SRP193095 | WWTR1 | 25937 | RNAseq | -0.2696 | 0.1759 | |
| SRP219564 | WWTR1 | 25937 | RNAseq | -0.4731 | 0.4650 | |
| TCGA | WWTR1 | 25937 | RNAseq | -0.1057 | 0.1823 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by WWTR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WWTR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WWTR1 | 25937 | 22 | 0 | 8 | |
| GSE20123 | WWTR1 | 25937 | 22 | 0 | 8 | |
| GSE43470 | WWTR1 | 25937 | 23 | 0 | 20 | |
| GSE46452 | WWTR1 | 25937 | 18 | 2 | 39 | |
| GSE47630 | WWTR1 | 25937 | 19 | 3 | 18 | |
| GSE54993 | WWTR1 | 25937 | 1 | 10 | 59 | |
| GSE54994 | WWTR1 | 25937 | 37 | 1 | 15 | |
| GSE60625 | WWTR1 | 25937 | 0 | 6 | 5 | |
| GSE74703 | WWTR1 | 25937 | 20 | 0 | 16 | |
| GSE74704 | WWTR1 | 25937 | 15 | 0 | 5 | |
| TCGA | WWTR1 | 25937 | 72 | 1 | 23 |
Total number of gains: 249; Total number of losses: 23; Total Number of normals: 216.
Somatic mutations of WWTR1:
Generating mutation plots.
Highly correlated genes for WWTR1:
Showing top 20/724 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WWTR1 | DAAM2 | 0.801298 | 5 | 0 | 5 |
| WWTR1 | CYP4V2 | 0.793802 | 3 | 0 | 3 |
| WWTR1 | CPXM2 | 0.779157 | 4 | 0 | 4 |
| WWTR1 | FIBIN | 0.778759 | 4 | 0 | 4 |
| WWTR1 | DMD | 0.775226 | 7 | 0 | 7 |
| WWTR1 | MSRB3 | 0.763524 | 5 | 0 | 4 |
| WWTR1 | CREB3 | 0.763341 | 3 | 0 | 3 |
| WWTR1 | APOD | 0.762558 | 5 | 0 | 5 |
| WWTR1 | ZNF248 | 0.759594 | 3 | 0 | 3 |
| WWTR1 | KLF11 | 0.758408 | 4 | 0 | 4 |
| WWTR1 | PRELP | 0.757535 | 5 | 0 | 5 |
| WWTR1 | TBX5 | 0.753786 | 6 | 0 | 6 |
| WWTR1 | CBX7 | 0.753 | 5 | 0 | 5 |
| WWTR1 | FBXL3 | 0.752863 | 3 | 0 | 3 |
| WWTR1 | FBXO30 | 0.749708 | 4 | 0 | 4 |
| WWTR1 | C11orf58 | 0.748191 | 3 | 0 | 3 |
| WWTR1 | XPC | 0.747476 | 3 | 0 | 3 |
| WWTR1 | SPARCL1 | 0.745582 | 7 | 0 | 7 |
| WWTR1 | SLIT2 | 0.745474 | 6 | 0 | 6 |
| WWTR1 | RBMS3 | 0.744303 | 5 | 0 | 5 |
For details and further investigation, click here
