MSH6

 

Full name: mutS homolog 6 Alias Symbol: 
Type: protein-coding gene Cytoband: 2p16.3
Entrez ID: 2956 HGNC ID: HGNC:7329 Ensembl Gene: ENSG00000116062 OMIM ID: 600678
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of MSH6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MSH6 2956 202911_at 1.1836 0.0497
GSE20347 MSH6 2956 202911_at 1.2952 0.0000
GSE23400 MSH6 2956 202911_at 1.2203 0.0000
GSE26886 MSH6 2956 202911_at 0.5970 0.0138
GSE29001 MSH6 2956 202911_at 1.1968 0.0004
GSE38129 MSH6 2956 202911_at 1.1980 0.0000
GSE45670 MSH6 2956 202911_at 0.6054 0.0061
GSE53622 MSH6 2956 34718 0.9464 0.0000
GSE53624 MSH6 2956 34718 1.0960 0.0000
GSE63941 MSH6 2956 202911_at 0.9283 0.0238
GSE77861 MSH6 2956 202911_at 1.0706 0.0014
GSE97050 MSH6 2956 A_23_P102202 0.0524 0.8736
SRP007169 MSH6 2956 RNAseq 2.3538 0.0000
SRP008496 MSH6 2956 RNAseq 2.3716 0.0000
SRP064894 MSH6 2956 RNAseq 0.8111 0.0000
SRP133303 MSH6 2956 RNAseq 0.8800 0.0000
SRP159526 MSH6 2956 RNAseq 1.5709 0.0000
SRP193095 MSH6 2956 RNAseq 1.0292 0.0000
SRP219564 MSH6 2956 RNAseq 1.1182 0.0088
TCGA MSH6 2956 RNAseq 0.2791 0.0000

Upregulated datasets: 12; Downregulated datasets: 0.  

 

Survival by MSH6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MSH6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MSH6 2956 8 1 21
GSE20123 MSH6 2956 7 1 22
GSE43470 MSH6 2956 5 0 38
GSE46452 MSH6 2956 1 4 54
GSE47630 MSH6 2956 8 0 32
GSE54993 MSH6 2956 0 5 65
GSE54994 MSH6 2956 12 0 41
GSE60625 MSH6 2956 0 3 8
GSE74703 MSH6 2956 5 0 31
GSE74704 MSH6 2956 8 1 11
TCGA MSH6 2956 36 2 58

Total number of gains: 90; Total number of losses: 17; Total Number of normals: 381.  

 

Somatic mutations of MSH6:

 

Generating mutation plots.

 

Highly correlated genes for MSH6:

 

Showing top 20/2106 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MSH6MCM30.84000712012
MSH6RFC40.81800712012
MSH6MCM60.81351113012
MSH6CKS1B0.79535611011
MSH6PARP10.78904413013
MSH6XPO10.78778913012
MSH6ELOF10.780463303
MSH6MSH20.77789813012
MSH6RNPS10.77428710010
MSH6E2F60.77124412012
MSH6RAD51AP10.76892212012
MSH6DUS3L0.768447404
MSH6DNMT10.76343713012
MSH6CAD0.76140412012
MSH6MTHFD20.76063811011
MSH6NCAPG20.75703411011
MSH6HLTF0.75608912012
MSH6C1orf1120.75251411011
MSH6SNRPE0.75211312011
MSH6RAB340.751592303

For details and further investigation, click here