MCM6

 

Full name: minichromosome maintenance complex component 6 Alias Symbol: Mis5
Type: protein-coding gene Cytoband: 2q21.3
Entrez ID: 4175 HGNC ID: HGNC:6949 Ensembl Gene: ENSG00000076003 OMIM ID: 601806
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

MCM6 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle

 

Expression of MCM6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MCM6 4175 201930_at 1.1631 0.0086
GSE20347 MCM6 4175 201930_at 1.1189 0.0000
GSE23400 MCM6 4175 201930_at 1.4124 0.0000
GSE26886 MCM6 4175 201930_at 1.2108 0.0000
GSE29001 MCM6 4175 201930_at 1.2212 0.0057
GSE38129 MCM6 4175 201930_at 1.2551 0.0000
GSE45670 MCM6 4175 201930_at 0.8273 0.0010
GSE53622 MCM6 4175 112037 1.0919 0.0000
GSE53624 MCM6 4175 112037 1.3303 0.0000
GSE63941 MCM6 4175 201930_at 1.9679 0.0013
GSE77861 MCM6 4175 201930_at 1.0025 0.0008
GSE97050 MCM6 4175 A_23_P90612 0.6367 0.1323
SRP007169 MCM6 4175 RNAseq 2.4549 0.0000
SRP008496 MCM6 4175 RNAseq 2.2492 0.0000
SRP064894 MCM6 4175 RNAseq 1.0121 0.0000
SRP133303 MCM6 4175 RNAseq 0.9897 0.0000
SRP159526 MCM6 4175 RNAseq 1.0086 0.0096
SRP193095 MCM6 4175 RNAseq 0.5448 0.0000
SRP219564 MCM6 4175 RNAseq 0.7985 0.0046
TCGA MCM6 4175 RNAseq 0.4147 0.0000

Upregulated datasets: 14; Downregulated datasets: 0.  

 

Survival by MCM6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MCM6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MCM6 4175 2 4 24
GSE20123 MCM6 4175 2 4 24
GSE43470 MCM6 4175 2 1 40
GSE46452 MCM6 4175 1 4 54
GSE47630 MCM6 4175 5 2 33
GSE54993 MCM6 4175 0 6 64
GSE54994 MCM6 4175 9 0 44
GSE60625 MCM6 4175 0 3 8
GSE74703 MCM6 4175 2 1 33
GSE74704 MCM6 4175 1 1 18
TCGA MCM6 4175 21 10 65

Total number of gains: 45; Total number of losses: 36; Total Number of normals: 407.  

 

Somatic mutations of MCM6:

 

Generating mutation plots.

 

Highly correlated genes for MCM6:

 

Showing top 20/2103 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MCM6MCM20.84776812012
MCM6MCM30.84113612012
MCM6GMNN0.835813013
MCM6RAD51AP10.83419112012
MCM6MMS22L0.832333303
MCM6DTL0.82886713013
MCM6DNMT10.8250613013
MCM6RFC40.82238913012
MCM6GINS10.8195212012
MCM6CCNB20.81917912012
MCM6ECT20.81719812012
MCM6XPO10.81447111011
MCM6MSH60.81351113012
MCM6MTHFD20.8134611011
MCM6PCNA0.8093413013
MCM6TPX20.80833713013
MCM6KNSTRN0.802033707
MCM6TIMELESS0.80164813012
MCM6UBE2T0.801351908
MCM6MTFR20.801349707

For details and further investigation, click here