| Full name: deoxythymidylate kinase | Alias Symbol: CDC8|TYMK|TMPK | ||
| Type: protein-coding gene | Cytoband: 2q37.3 | ||
| Entrez ID: 1841 | HGNC ID: HGNC:3061 | Ensembl Gene: ENSG00000168393 | OMIM ID: 188345 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of DTYMK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DTYMK | 1841 | 1553984_s_at | 0.5665 | 0.3093 | |
| GSE20347 | DTYMK | 1841 | 203270_at | 0.8306 | 0.0001 | |
| GSE23400 | DTYMK | 1841 | 203270_at | 0.6036 | 0.0000 | |
| GSE26886 | DTYMK | 1841 | 1553984_s_at | 1.0752 | 0.0001 | |
| GSE29001 | DTYMK | 1841 | 203270_at | 0.8317 | 0.0054 | |
| GSE38129 | DTYMK | 1841 | 203270_at | 0.9860 | 0.0000 | |
| GSE45670 | DTYMK | 1841 | 1553984_s_at | 0.9675 | 0.0000 | |
| GSE53622 | DTYMK | 1841 | 29875 | 0.7131 | 0.0000 | |
| GSE53624 | DTYMK | 1841 | 104910 | 1.0986 | 0.0000 | |
| GSE63941 | DTYMK | 1841 | 1553984_s_at | 0.5573 | 0.1988 | |
| GSE77861 | DTYMK | 1841 | 1553984_s_at | 0.6444 | 0.0047 | |
| GSE97050 | DTYMK | 1841 | A_23_P123974 | 0.7655 | 0.1049 | |
| SRP007169 | DTYMK | 1841 | RNAseq | 1.4400 | 0.0010 | |
| SRP008496 | DTYMK | 1841 | RNAseq | 1.3492 | 0.0003 | |
| SRP064894 | DTYMK | 1841 | RNAseq | 1.4401 | 0.0000 | |
| SRP133303 | DTYMK | 1841 | RNAseq | 1.0962 | 0.0000 | |
| SRP159526 | DTYMK | 1841 | RNAseq | 0.9899 | 0.0033 | |
| SRP193095 | DTYMK | 1841 | RNAseq | 0.6095 | 0.0000 | |
| SRP219564 | DTYMK | 1841 | RNAseq | 1.0495 | 0.0288 | |
| TCGA | DTYMK | 1841 | RNAseq | 0.4559 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by DTYMK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DTYMK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DTYMK | 1841 | 1 | 12 | 17 | |
| GSE20123 | DTYMK | 1841 | 1 | 12 | 17 | |
| GSE43470 | DTYMK | 1841 | 1 | 9 | 33 | |
| GSE46452 | DTYMK | 1841 | 0 | 5 | 54 | |
| GSE47630 | DTYMK | 1841 | 4 | 5 | 31 | |
| GSE54993 | DTYMK | 1841 | 4 | 3 | 63 | |
| GSE54994 | DTYMK | 1841 | 8 | 9 | 36 | |
| GSE60625 | DTYMK | 1841 | 0 | 3 | 8 | |
| GSE74703 | DTYMK | 1841 | 1 | 7 | 28 | |
| GSE74704 | DTYMK | 1841 | 1 | 5 | 14 | |
| TCGA | DTYMK | 1841 | 11 | 29 | 56 |
Total number of gains: 32; Total number of losses: 99; Total Number of normals: 357.
Somatic mutations of DTYMK:
Generating mutation plots.
Highly correlated genes for DTYMK:
Showing top 20/2100 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DTYMK | TRAF7 | 0.845149 | 4 | 0 | 4 |
| DTYMK | CENPBD1 | 0.787535 | 3 | 0 | 3 |
| DTYMK | EARS2 | 0.78562 | 5 | 0 | 5 |
| DTYMK | CCNB2 | 0.785576 | 11 | 0 | 11 |
| DTYMK | DOCK11 | 0.783317 | 3 | 0 | 3 |
| DTYMK | CDCA3 | 0.779214 | 12 | 0 | 12 |
| DTYMK | SLC39A3 | 0.779013 | 3 | 0 | 3 |
| DTYMK | MCM6 | 0.777907 | 12 | 0 | 12 |
| DTYMK | HJURP | 0.771568 | 12 | 0 | 12 |
| DTYMK | DEXI | 0.770129 | 3 | 0 | 3 |
| DTYMK | EBNA1BP2 | 0.768911 | 3 | 0 | 3 |
| DTYMK | TTL | 0.768706 | 6 | 0 | 6 |
| DTYMK | KDSR | 0.766638 | 3 | 0 | 3 |
| DTYMK | NCAPG2 | 0.765453 | 11 | 0 | 11 |
| DTYMK | ANAPC1 | 0.765028 | 3 | 0 | 3 |
| DTYMK | XPO1 | 0.764969 | 10 | 0 | 10 |
| DTYMK | UBE2C | 0.756431 | 12 | 0 | 12 |
| DTYMK | HAS3 | 0.755482 | 4 | 0 | 3 |
| DTYMK | DNMBP | 0.752851 | 3 | 0 | 3 |
| DTYMK | DLGAP5 | 0.752512 | 11 | 0 | 11 |
For details and further investigation, click here
