YES1

 

Full name: YES proto-oncogene 1, Src family tyrosine kinase Alias Symbol: Yes|c-yes|HsT441
Type: protein-coding gene Cytoband: 18p11.32
Entrez ID: 7525 HGNC ID: HGNC:12841 Ensembl Gene: ENSG00000176105 OMIM ID: 164880
Drug and gene relationship at DGIdb
Screen Evidence:

 

YES1 involved pathways:

KEGG pathway Description View
hsa04520Adherens junction

 

Expression of YES1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 YES1 7525 202933_s_at 0.3521 0.6916
GSE20347 YES1 7525 202933_s_at 0.2282 0.1028
GSE23400 YES1 7525 202932_at 0.3211 0.0015
GSE26886 YES1 7525 202933_s_at 0.0815 0.7073
GSE29001 YES1 7525 202933_s_at 0.2448 0.1973
GSE38129 YES1 7525 202933_s_at 0.2829 0.0816
GSE45670 YES1 7525 202933_s_at 0.2520 0.0344
GSE53622 YES1 7525 32477 0.2215 0.0129
GSE53624 YES1 7525 32477 0.1733 0.0694
GSE63941 YES1 7525 202933_s_at 0.4463 0.3949
GSE77861 YES1 7525 202933_s_at 0.2863 0.0791
GSE97050 YES1 7525 A_24_P48403 0.3174 0.3225
SRP007169 YES1 7525 RNAseq 0.0240 0.9453
SRP008496 YES1 7525 RNAseq -0.1010 0.6530
SRP064894 YES1 7525 RNAseq 0.2343 0.4435
SRP133303 YES1 7525 RNAseq 0.7393 0.0003
SRP159526 YES1 7525 RNAseq 0.2656 0.3776
SRP193095 YES1 7525 RNAseq 0.0837 0.5905
SRP219564 YES1 7525 RNAseq -0.3964 0.1777
TCGA YES1 7525 RNAseq 0.0841 0.1378

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by YES1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of YES1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 YES1 7525 6 3 21
GSE20123 YES1 7525 6 3 21
GSE43470 YES1 7525 2 4 37
GSE46452 YES1 7525 4 20 35
GSE47630 YES1 7525 7 18 15
GSE54993 YES1 7525 6 3 61
GSE54994 YES1 7525 11 8 34
GSE60625 YES1 7525 0 4 7
GSE74703 YES1 7525 2 2 32
GSE74704 YES1 7525 4 2 14
TCGA YES1 7525 35 18 43

Total number of gains: 83; Total number of losses: 85; Total Number of normals: 320.  

 

Somatic mutations of YES1:

 

Generating mutation plots.

 

Highly correlated genes for YES1:

 

Showing top 20/394 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
YES1MRPL520.752696404
YES1MIPOL10.732788303
YES1EAF10.730157303
YES1ZNF8080.727277303
YES1TPCN20.727102303
YES1ANAPC130.726384303
YES1PPP6R30.722034404
YES1PPIL40.709526303
YES1IWS10.70269303
YES1RASA20.693257303
YES1CCDC1380.682163303
YES1PWP10.679447303
YES1PIBF10.678662403
YES1SRD5A30.675599303
YES1CEP700.674054303
YES1GNL3L0.669563503
YES1OPA10.669177303
YES1SPPL2A0.661772303
YES1DMTF10.657454303
YES1SLC2A90.651537504

For details and further investigation, click here