| Full name: signal peptide peptidase like 2A | Alias Symbol: IMP3|PSL2 | ||
| Type: protein-coding gene | Cytoband: 15q21.2 | ||
| Entrez ID: 84888 | HGNC ID: HGNC:30227 | Ensembl Gene: ENSG00000138600 | OMIM ID: 608238 |
| Drug and gene relationship at DGIdb | |||
Expression of SPPL2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPPL2A | 84888 | 226353_at | 0.0171 | 0.9798 | |
| GSE26886 | SPPL2A | 84888 | 226353_at | -0.1064 | 0.7170 | |
| GSE45670 | SPPL2A | 84888 | 226353_at | 0.3687 | 0.0219 | |
| GSE53622 | SPPL2A | 84888 | 168018 | 0.1045 | 0.2865 | |
| GSE53624 | SPPL2A | 84888 | 168018 | 0.3524 | 0.0051 | |
| GSE63941 | SPPL2A | 84888 | 226353_at | -0.9010 | 0.0670 | |
| GSE77861 | SPPL2A | 84888 | 226353_at | 0.4194 | 0.1249 | |
| GSE97050 | SPPL2A | 84888 | A_23_P77073 | -0.2421 | 0.2501 | |
| SRP007169 | SPPL2A | 84888 | RNAseq | 0.1772 | 0.5459 | |
| SRP008496 | SPPL2A | 84888 | RNAseq | 0.3778 | 0.1194 | |
| SRP064894 | SPPL2A | 84888 | RNAseq | 0.4919 | 0.0006 | |
| SRP133303 | SPPL2A | 84888 | RNAseq | 0.4863 | 0.0132 | |
| SRP159526 | SPPL2A | 84888 | RNAseq | 0.2379 | 0.5362 | |
| SRP193095 | SPPL2A | 84888 | RNAseq | -0.0483 | 0.7366 | |
| SRP219564 | SPPL2A | 84888 | RNAseq | 0.3145 | 0.2316 | |
| TCGA | SPPL2A | 84888 | RNAseq | -0.0557 | 0.2647 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPPL2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPPL2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPPL2A | 84888 | 5 | 3 | 22 | |
| GSE20123 | SPPL2A | 84888 | 5 | 3 | 22 | |
| GSE43470 | SPPL2A | 84888 | 5 | 3 | 35 | |
| GSE46452 | SPPL2A | 84888 | 3 | 7 | 49 | |
| GSE47630 | SPPL2A | 84888 | 8 | 10 | 22 | |
| GSE54993 | SPPL2A | 84888 | 4 | 6 | 60 | |
| GSE54994 | SPPL2A | 84888 | 5 | 7 | 41 | |
| GSE60625 | SPPL2A | 84888 | 4 | 0 | 7 | |
| GSE74703 | SPPL2A | 84888 | 5 | 2 | 29 | |
| GSE74704 | SPPL2A | 84888 | 2 | 3 | 15 | |
| TCGA | SPPL2A | 84888 | 9 | 16 | 71 |
Total number of gains: 55; Total number of losses: 60; Total Number of normals: 373.
Somatic mutations of SPPL2A:
Generating mutation plots.
Highly correlated genes for SPPL2A:
Showing top 20/301 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPPL2A | EID1 | 0.844091 | 3 | 0 | 3 |
| SPPL2A | RPS6KA3 | 0.819064 | 3 | 0 | 3 |
| SPPL2A | STEAP1 | 0.789441 | 3 | 0 | 3 |
| SPPL2A | OSGEPL1 | 0.785456 | 3 | 0 | 3 |
| SPPL2A | ZFR | 0.782239 | 3 | 0 | 3 |
| SPPL2A | MBTPS2 | 0.755523 | 3 | 0 | 3 |
| SPPL2A | SMARCA5 | 0.753741 | 3 | 0 | 3 |
| SPPL2A | RPS19BP1 | 0.752427 | 3 | 0 | 3 |
| SPPL2A | CUL1 | 0.742137 | 3 | 0 | 3 |
| SPPL2A | TOR1B | 0.736164 | 3 | 0 | 3 |
| SPPL2A | TMEM38B | 0.731399 | 3 | 0 | 3 |
| SPPL2A | MAP2K1 | 0.728338 | 4 | 0 | 3 |
| SPPL2A | INPP4A | 0.727045 | 3 | 0 | 3 |
| SPPL2A | TTF2 | 0.726381 | 3 | 0 | 3 |
| SPPL2A | LY96 | 0.723438 | 3 | 0 | 3 |
| SPPL2A | MAK16 | 0.722108 | 3 | 0 | 3 |
| SPPL2A | TLR1 | 0.719594 | 3 | 0 | 3 |
| SPPL2A | DENND4A | 0.71413 | 4 | 0 | 3 |
| SPPL2A | MKNK1 | 0.71357 | 3 | 0 | 3 |
| SPPL2A | LRRC59 | 0.712445 | 3 | 0 | 3 |
For details and further investigation, click here
