| Full name: steroid 5 alpha-reductase 3 | Alias Symbol: FLJ13352|SRD5A2L|SRD5A2L1 | ||
| Type: protein-coding gene | Cytoband: 4q12 | ||
| Entrez ID: 79644 | HGNC ID: HGNC:25812 | Ensembl Gene: ENSG00000128039 | OMIM ID: 611715 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SRD5A3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRD5A3 | 79644 | 222750_s_at | 0.0740 | 0.9304 | |
| GSE20347 | SRD5A3 | 79644 | 218800_at | 0.0441 | 0.6773 | |
| GSE23400 | SRD5A3 | 79644 | 218800_at | 0.0394 | 0.1037 | |
| GSE26886 | SRD5A3 | 79644 | 222750_s_at | -0.8541 | 0.0101 | |
| GSE29001 | SRD5A3 | 79644 | 218800_at | 0.0611 | 0.7990 | |
| GSE38129 | SRD5A3 | 79644 | 218800_at | 0.2635 | 0.0725 | |
| GSE45670 | SRD5A3 | 79644 | 222750_s_at | 0.3553 | 0.1509 | |
| GSE53622 | SRD5A3 | 79644 | 5319 | -0.0767 | 0.4880 | |
| GSE53624 | SRD5A3 | 79644 | 5319 | -0.0101 | 0.9268 | |
| GSE63941 | SRD5A3 | 79644 | 222750_s_at | 0.6364 | 0.5316 | |
| GSE77861 | SRD5A3 | 79644 | 222750_s_at | -0.4852 | 0.1892 | |
| GSE97050 | SRD5A3 | 79644 | A_33_P3389023 | 0.2617 | 0.3508 | |
| SRP007169 | SRD5A3 | 79644 | RNAseq | -1.4277 | 0.0009 | |
| SRP008496 | SRD5A3 | 79644 | RNAseq | -1.4315 | 0.0000 | |
| SRP064894 | SRD5A3 | 79644 | RNAseq | 0.3995 | 0.1123 | |
| SRP133303 | SRD5A3 | 79644 | RNAseq | 0.3502 | 0.0633 | |
| SRP159526 | SRD5A3 | 79644 | RNAseq | -0.6046 | 0.0063 | |
| SRP193095 | SRD5A3 | 79644 | RNAseq | -0.3089 | 0.0371 | |
| SRP219564 | SRD5A3 | 79644 | RNAseq | -0.2386 | 0.6184 | |
| TCGA | SRD5A3 | 79644 | RNAseq | 0.0856 | 0.2695 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SRD5A3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SRD5A3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRD5A3 | 79644 | 3 | 11 | 16 | |
| GSE20123 | SRD5A3 | 79644 | 2 | 11 | 17 | |
| GSE43470 | SRD5A3 | 79644 | 0 | 14 | 29 | |
| GSE46452 | SRD5A3 | 79644 | 1 | 36 | 22 | |
| GSE47630 | SRD5A3 | 79644 | 1 | 18 | 21 | |
| GSE54993 | SRD5A3 | 79644 | 7 | 0 | 63 | |
| GSE54994 | SRD5A3 | 79644 | 2 | 10 | 41 | |
| GSE60625 | SRD5A3 | 79644 | 0 | 0 | 11 | |
| GSE74703 | SRD5A3 | 79644 | 0 | 12 | 24 | |
| GSE74704 | SRD5A3 | 79644 | 1 | 6 | 13 | |
| TCGA | SRD5A3 | 79644 | 20 | 27 | 49 |
Total number of gains: 37; Total number of losses: 145; Total Number of normals: 306.
Somatic mutations of SRD5A3:
Generating mutation plots.
Highly correlated genes for SRD5A3:
Showing top 20/255 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRD5A3 | TMEM167A | 0.769557 | 3 | 0 | 3 |
| SRD5A3 | OSBPL2 | 0.766476 | 3 | 0 | 3 |
| SRD5A3 | STXBP5 | 0.751918 | 3 | 0 | 3 |
| SRD5A3 | TOR1AIP2 | 0.713762 | 3 | 0 | 3 |
| SRD5A3 | UNC5B | 0.7043 | 4 | 0 | 3 |
| SRD5A3 | ECHS1 | 0.701459 | 3 | 0 | 3 |
| SRD5A3 | CNOT6L | 0.701132 | 3 | 0 | 3 |
| SRD5A3 | DLG2 | 0.700819 | 3 | 0 | 3 |
| SRD5A3 | SIAE | 0.695584 | 4 | 0 | 4 |
| SRD5A3 | TMEM161B | 0.694643 | 3 | 0 | 3 |
| SRD5A3 | BAIAP2L1 | 0.691077 | 3 | 0 | 3 |
| SRD5A3 | MAP3K1 | 0.690452 | 3 | 0 | 3 |
| SRD5A3 | LY75 | 0.688509 | 3 | 0 | 3 |
| SRD5A3 | TXNDC9 | 0.686855 | 3 | 0 | 3 |
| SRD5A3 | EBPL | 0.680677 | 4 | 0 | 3 |
| SRD5A3 | MYL12B | 0.680541 | 3 | 0 | 3 |
| SRD5A3 | OGFRL1 | 0.680456 | 3 | 0 | 3 |
| SRD5A3 | OSTF1 | 0.679957 | 3 | 0 | 3 |
| SRD5A3 | SAMD8 | 0.678274 | 3 | 0 | 3 |
| SRD5A3 | GUK1 | 0.676583 | 4 | 0 | 3 |
For details and further investigation, click here
