ZNF189

 

Full name: zinc finger protein 189 Alias Symbol: 
Type: protein-coding gene Cytoband: 9q31.1
Entrez ID: 7743 HGNC ID: HGNC:12980 Ensembl Gene: ENSG00000136870 OMIM ID: 603132
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ZNF189:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ZNF189 7743 207513_s_at -0.2945 0.5695
GSE20347 ZNF189 7743 207513_s_at 0.0012 0.9944
GSE23400 ZNF189 7743 207513_s_at 0.2098 0.0000
GSE26886 ZNF189 7743 207513_s_at 0.7460 0.0015
GSE29001 ZNF189 7743 207513_s_at 0.1613 0.6758
GSE38129 ZNF189 7743 207513_s_at 0.0260 0.8621
GSE45670 ZNF189 7743 207513_s_at 0.1543 0.2742
GSE53622 ZNF189 7743 22784 -0.1999 0.0338
GSE53624 ZNF189 7743 22784 0.1087 0.1427
GSE63941 ZNF189 7743 207513_s_at -0.5348 0.2047
GSE77861 ZNF189 7743 207513_s_at 0.1898 0.2341
GSE97050 ZNF189 7743 A_24_P89872 -0.3818 0.2669
SRP007169 ZNF189 7743 RNAseq 0.6334 0.1880
SRP008496 ZNF189 7743 RNAseq 0.6129 0.0314
SRP064894 ZNF189 7743 RNAseq 0.1390 0.4424
SRP133303 ZNF189 7743 RNAseq 0.0340 0.8376
SRP159526 ZNF189 7743 RNAseq 0.5889 0.0311
SRP193095 ZNF189 7743 RNAseq 0.0355 0.7980
SRP219564 ZNF189 7743 RNAseq 0.0161 0.9614
TCGA ZNF189 7743 RNAseq -0.2607 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ZNF189 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ZNF189:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ZNF189 7743 4 10 16
GSE20123 ZNF189 7743 5 9 16
GSE43470 ZNF189 7743 6 3 34
GSE46452 ZNF189 7743 6 13 40
GSE47630 ZNF189 7743 1 17 22
GSE54993 ZNF189 7743 3 3 64
GSE54994 ZNF189 7743 9 11 33
GSE60625 ZNF189 7743 0 0 11
GSE74703 ZNF189 7743 5 3 28
GSE74704 ZNF189 7743 2 6 12
TCGA ZNF189 7743 28 21 47

Total number of gains: 69; Total number of losses: 96; Total Number of normals: 323.  

 

Somatic mutations of ZNF189:

 

Generating mutation plots.

 

Highly correlated genes for ZNF189:

 

Showing top 20/374 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ZNF189CELF60.740001303
ZNF189ZER10.704988303
ZNF189NPIPA10.69235303
ZNF189ANAPC160.686119303
ZNF189ZBED10.674773303
ZNF189PARP60.669023303
ZNF189CACNA2D20.66382303
ZNF189ZNF5860.6618303
ZNF189HELZ0.658731404
ZNF189MAML10.654177403
ZNF189FOXN30.651714303
ZNF189PPP1R350.650854303
ZNF189FAM149A0.648956303
ZNF189SESTD10.645427504
ZNF189STX80.640124303
ZNF189NOL90.637599403
ZNF189DDX170.634209503
ZNF189KIAA11070.629577403
ZNF189TRAK20.629456303
ZNF189TMEM2450.629074504

For details and further investigation, click here