| Full name: calcium voltage-gated channel auxiliary subunit alpha2delta 2 | Alias Symbol: KIAA0558 | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 9254 | HGNC ID: HGNC:1400 | Ensembl Gene: ENSG00000007402 | OMIM ID: 607082 |
| Drug and gene relationship at DGIdb | |||
CACNA2D2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04261 | Adrenergic signaling in cardiomyocytes | |
| hsa04921 | Oxytocin signaling pathway |
Expression of CACNA2D2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CACNA2D2 | 9254 | 204811_s_at | -0.2793 | 0.4581 | |
| GSE20347 | CACNA2D2 | 9254 | 204811_s_at | -0.0624 | 0.5662 | |
| GSE23400 | CACNA2D2 | 9254 | 204811_s_at | -0.1348 | 0.0054 | |
| GSE26886 | CACNA2D2 | 9254 | 204811_s_at | 0.0329 | 0.8656 | |
| GSE29001 | CACNA2D2 | 9254 | 204811_s_at | 0.0423 | 0.9237 | |
| GSE38129 | CACNA2D2 | 9254 | 204811_s_at | -0.3275 | 0.1285 | |
| GSE45670 | CACNA2D2 | 9254 | 204811_s_at | -0.1681 | 0.6400 | |
| GSE53622 | CACNA2D2 | 9254 | 63525 | -0.8621 | 0.0000 | |
| GSE53624 | CACNA2D2 | 9254 | 63525 | -0.7179 | 0.0000 | |
| GSE63941 | CACNA2D2 | 9254 | 204811_s_at | 0.2817 | 0.5839 | |
| GSE77861 | CACNA2D2 | 9254 | 204811_s_at | -0.0992 | 0.3471 | |
| GSE97050 | CACNA2D2 | 9254 | A_23_P346900 | -0.3003 | 0.2885 | |
| SRP064894 | CACNA2D2 | 9254 | RNAseq | -0.5200 | 0.0348 | |
| SRP133303 | CACNA2D2 | 9254 | RNAseq | -0.9118 | 0.0012 | |
| SRP159526 | CACNA2D2 | 9254 | RNAseq | 0.7191 | 0.1680 | |
| SRP219564 | CACNA2D2 | 9254 | RNAseq | -0.3067 | 0.5766 | |
| TCGA | CACNA2D2 | 9254 | RNAseq | -1.5964 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CACNA2D2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CACNA2D2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CACNA2D2 | 9254 | 0 | 18 | 12 | |
| GSE20123 | CACNA2D2 | 9254 | 0 | 19 | 11 | |
| GSE43470 | CACNA2D2 | 9254 | 0 | 19 | 24 | |
| GSE46452 | CACNA2D2 | 9254 | 2 | 16 | 41 | |
| GSE47630 | CACNA2D2 | 9254 | 1 | 24 | 15 | |
| GSE54993 | CACNA2D2 | 9254 | 6 | 2 | 62 | |
| GSE54994 | CACNA2D2 | 9254 | 0 | 34 | 19 | |
| GSE60625 | CACNA2D2 | 9254 | 5 | 0 | 6 | |
| GSE74703 | CACNA2D2 | 9254 | 0 | 15 | 21 | |
| GSE74704 | CACNA2D2 | 9254 | 0 | 12 | 8 | |
| TCGA | CACNA2D2 | 9254 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 237; Total Number of normals: 237.
Somatic mutations of CACNA2D2:
Generating mutation plots.
Highly correlated genes for CACNA2D2:
Showing top 20/868 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CACNA2D2 | C9orf47 | 0.860984 | 3 | 0 | 3 |
| CACNA2D2 | IQUB | 0.781271 | 3 | 0 | 3 |
| CACNA2D2 | PGR | 0.761003 | 4 | 0 | 4 |
| CACNA2D2 | SORCS1 | 0.756833 | 4 | 0 | 4 |
| CACNA2D2 | HABP4 | 0.753366 | 5 | 0 | 5 |
| CACNA2D2 | PI16 | 0.745324 | 4 | 0 | 4 |
| CACNA2D2 | CC2D2A | 0.743128 | 3 | 0 | 3 |
| CACNA2D2 | CAMK2G | 0.740929 | 4 | 0 | 4 |
| CACNA2D2 | TIMP3 | 0.737885 | 3 | 0 | 3 |
| CACNA2D2 | INMT | 0.737109 | 4 | 0 | 4 |
| CACNA2D2 | RASSF3 | 0.736005 | 3 | 0 | 3 |
| CACNA2D2 | ANAPC16 | 0.734854 | 4 | 0 | 4 |
| CACNA2D2 | MAMDC2 | 0.732292 | 4 | 0 | 4 |
| CACNA2D2 | MRVI1 | 0.730862 | 4 | 0 | 4 |
| CACNA2D2 | RGMB | 0.727113 | 4 | 0 | 3 |
| CACNA2D2 | PPP3CB | 0.725247 | 4 | 0 | 4 |
| CACNA2D2 | FENDRR | 0.721117 | 3 | 0 | 3 |
| CACNA2D2 | TNFSF12 | 0.720819 | 3 | 0 | 3 |
| CACNA2D2 | ITIH6 | 0.713429 | 3 | 0 | 3 |
| CACNA2D2 | EBF2 | 0.712725 | 4 | 0 | 4 |
For details and further investigation, click here
