| Full name: tripeptidyl peptidase 2 | Alias Symbol: TPPII | ||
| Type: protein-coding gene | Cytoband: 13q33.1 | ||
| Entrez ID: 7174 | HGNC ID: HGNC:12016 | Ensembl Gene: ENSG00000134900 | OMIM ID: 190470 |
| Drug and gene relationship at DGIdb | |||
Expression of TPP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TPP2 | 7174 | 203374_s_at | 0.0681 | 0.9011 | |
| GSE20347 | TPP2 | 7174 | 203375_s_at | -0.1799 | 0.3934 | |
| GSE23400 | TPP2 | 7174 | 203374_s_at | 0.0882 | 0.1926 | |
| GSE26886 | TPP2 | 7174 | 203374_s_at | 0.2107 | 0.3100 | |
| GSE29001 | TPP2 | 7174 | 203374_s_at | 0.0164 | 0.9585 | |
| GSE38129 | TPP2 | 7174 | 203375_s_at | -0.1662 | 0.2261 | |
| GSE45670 | TPP2 | 7174 | 203374_s_at | 0.2827 | 0.1262 | |
| GSE53622 | TPP2 | 7174 | 7362 | 0.0088 | 0.8984 | |
| GSE53624 | TPP2 | 7174 | 7362 | 0.0737 | 0.2424 | |
| GSE63941 | TPP2 | 7174 | 203374_s_at | -0.5645 | 0.3914 | |
| GSE77861 | TPP2 | 7174 | 203374_s_at | -0.0513 | 0.7924 | |
| GSE97050 | TPP2 | 7174 | A_23_P99424 | 0.1066 | 0.6812 | |
| SRP007169 | TPP2 | 7174 | RNAseq | -0.3948 | 0.2051 | |
| SRP008496 | TPP2 | 7174 | RNAseq | -0.1959 | 0.3760 | |
| SRP064894 | TPP2 | 7174 | RNAseq | -0.0953 | 0.6727 | |
| SRP133303 | TPP2 | 7174 | RNAseq | -0.0754 | 0.3454 | |
| SRP159526 | TPP2 | 7174 | RNAseq | -0.3680 | 0.1661 | |
| SRP193095 | TPP2 | 7174 | RNAseq | -0.3503 | 0.0002 | |
| SRP219564 | TPP2 | 7174 | RNAseq | 0.1115 | 0.7380 | |
| TCGA | TPP2 | 7174 | RNAseq | -0.0663 | 0.1661 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TPP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TPP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TPP2 | 7174 | 3 | 9 | 18 | |
| GSE20123 | TPP2 | 7174 | 3 | 8 | 19 | |
| GSE43470 | TPP2 | 7174 | 4 | 12 | 27 | |
| GSE46452 | TPP2 | 7174 | 0 | 32 | 27 | |
| GSE47630 | TPP2 | 7174 | 3 | 26 | 11 | |
| GSE54993 | TPP2 | 7174 | 11 | 4 | 55 | |
| GSE54994 | TPP2 | 7174 | 6 | 10 | 37 | |
| GSE60625 | TPP2 | 7174 | 0 | 3 | 8 | |
| GSE74703 | TPP2 | 7174 | 3 | 10 | 23 | |
| GSE74704 | TPP2 | 7174 | 2 | 8 | 10 | |
| TCGA | TPP2 | 7174 | 15 | 35 | 46 |
Total number of gains: 50; Total number of losses: 157; Total Number of normals: 281.
Somatic mutations of TPP2:
Generating mutation plots.
Highly correlated genes for TPP2:
Showing top 20/170 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TPP2 | DENND1B | 0.769504 | 3 | 0 | 3 |
| TPP2 | SCYL3 | 0.763453 | 3 | 0 | 3 |
| TPP2 | CPLX1 | 0.759407 | 3 | 0 | 3 |
| TPP2 | WDR75 | 0.751194 | 3 | 0 | 3 |
| TPP2 | SUB1 | 0.742064 | 3 | 0 | 3 |
| TPP2 | EIF3M | 0.732506 | 3 | 0 | 3 |
| TPP2 | COMMD5 | 0.726001 | 3 | 0 | 3 |
| TPP2 | NIT2 | 0.719717 | 3 | 0 | 3 |
| TPP2 | SUGT1 | 0.709927 | 4 | 0 | 3 |
| TPP2 | ZNF274 | 0.709857 | 4 | 0 | 3 |
| TPP2 | PRPF4B | 0.708978 | 4 | 0 | 4 |
| TPP2 | RPS6KB1 | 0.70673 | 3 | 0 | 3 |
| TPP2 | REV1 | 0.696383 | 3 | 0 | 3 |
| TPP2 | ANKRD46 | 0.696383 | 3 | 0 | 3 |
| TPP2 | GGCX | 0.687104 | 3 | 0 | 3 |
| TPP2 | ZNF623 | 0.681818 | 3 | 0 | 3 |
| TPP2 | PTPN12 | 0.681672 | 3 | 0 | 3 |
| TPP2 | RPL7L1 | 0.679226 | 4 | 0 | 4 |
| TPP2 | EGLN1 | 0.673786 | 3 | 0 | 3 |
| TPP2 | ZNF557 | 0.673335 | 3 | 0 | 3 |
For details and further investigation, click here
