| Full name: muskelin 1 | Alias Symbol: TWA2 | ||
| Type: protein-coding gene | Cytoband: 7q32.3 | ||
| Entrez ID: 4289 | HGNC ID: HGNC:7109 | Ensembl Gene: ENSG00000128585 | OMIM ID: 605623 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MKLN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MKLN1 | 4289 | 225526_at | -0.3187 | 0.3557 | |
| GSE20347 | MKLN1 | 4289 | 204423_at | 0.1122 | 0.5988 | |
| GSE23400 | MKLN1 | 4289 | 204423_at | 0.0342 | 0.4939 | |
| GSE26886 | MKLN1 | 4289 | 204423_at | -0.6210 | 0.0291 | |
| GSE29001 | MKLN1 | 4289 | 204423_at | -0.0927 | 0.8198 | |
| GSE38129 | MKLN1 | 4289 | 204423_at | 0.2114 | 0.1467 | |
| GSE45670 | MKLN1 | 4289 | 225526_at | -0.3252 | 0.0312 | |
| GSE53622 | MKLN1 | 4289 | 39077 | -0.2625 | 0.0004 | |
| GSE53624 | MKLN1 | 4289 | 39077 | -0.0783 | 0.1877 | |
| GSE63941 | MKLN1 | 4289 | 225526_at | -1.1138 | 0.0774 | |
| GSE77861 | MKLN1 | 4289 | 225526_at | 0.3432 | 0.1269 | |
| GSE97050 | MKLN1 | 4289 | A_24_P914817 | -0.3426 | 0.1904 | |
| SRP007169 | MKLN1 | 4289 | RNAseq | 0.5911 | 0.0911 | |
| SRP008496 | MKLN1 | 4289 | RNAseq | 0.6679 | 0.0003 | |
| SRP064894 | MKLN1 | 4289 | RNAseq | -0.1846 | 0.2393 | |
| SRP133303 | MKLN1 | 4289 | RNAseq | -0.0019 | 0.9851 | |
| SRP159526 | MKLN1 | 4289 | RNAseq | -0.3825 | 0.0718 | |
| SRP193095 | MKLN1 | 4289 | RNAseq | -0.3075 | 0.0000 | |
| SRP219564 | MKLN1 | 4289 | RNAseq | -0.5094 | 0.0934 | |
| TCGA | MKLN1 | 4289 | RNAseq | -0.1823 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MKLN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MKLN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MKLN1 | 4289 | 8 | 1 | 21 | |
| GSE20123 | MKLN1 | 4289 | 8 | 1 | 21 | |
| GSE43470 | MKLN1 | 4289 | 2 | 3 | 38 | |
| GSE46452 | MKLN1 | 4289 | 7 | 2 | 50 | |
| GSE47630 | MKLN1 | 4289 | 7 | 4 | 29 | |
| GSE54993 | MKLN1 | 4289 | 3 | 5 | 62 | |
| GSE54994 | MKLN1 | 4289 | 7 | 7 | 39 | |
| GSE60625 | MKLN1 | 4289 | 0 | 0 | 11 | |
| GSE74703 | MKLN1 | 4289 | 2 | 3 | 31 | |
| GSE74704 | MKLN1 | 4289 | 4 | 1 | 15 | |
| TCGA | MKLN1 | 4289 | 27 | 23 | 46 |
Total number of gains: 75; Total number of losses: 50; Total Number of normals: 363.
Somatic mutations of MKLN1:
Generating mutation plots.
Highly correlated genes for MKLN1:
Showing top 20/400 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MKLN1 | PNKD | 0.825314 | 3 | 0 | 3 |
| MKLN1 | STK40 | 0.823667 | 3 | 0 | 3 |
| MKLN1 | NUP205 | 0.821051 | 3 | 0 | 3 |
| MKLN1 | FAM76B | 0.796622 | 3 | 0 | 3 |
| MKLN1 | CUL4B | 0.792881 | 3 | 0 | 3 |
| MKLN1 | MNS1 | 0.775512 | 3 | 0 | 3 |
| MKLN1 | CYP4V2 | 0.767739 | 3 | 0 | 3 |
| MKLN1 | CASP8AP2 | 0.766222 | 3 | 0 | 3 |
| MKLN1 | CCDC146 | 0.763007 | 3 | 0 | 3 |
| MKLN1 | TMEM181 | 0.75734 | 3 | 0 | 3 |
| MKLN1 | TMTC3 | 0.754281 | 3 | 0 | 3 |
| MKLN1 | USP8 | 0.753895 | 3 | 0 | 3 |
| MKLN1 | GPHN | 0.747523 | 3 | 0 | 3 |
| MKLN1 | TMEM209 | 0.747263 | 4 | 0 | 4 |
| MKLN1 | FUNDC2 | 0.736218 | 3 | 0 | 3 |
| MKLN1 | KIAA1143 | 0.73529 | 3 | 0 | 3 |
| MKLN1 | NPY1R | 0.731693 | 3 | 0 | 3 |
| MKLN1 | TNRC6B | 0.724876 | 3 | 0 | 3 |
| MKLN1 | TMEM106B | 0.722737 | 4 | 0 | 3 |
| MKLN1 | ECD | 0.72087 | 4 | 0 | 3 |
For details and further investigation, click here
