| Full name: adenosine monophosphate deaminase 2 | Alias Symbol: SPG63 | ||
| Type: protein-coding gene | Cytoband: 1p13.3 | ||
| Entrez ID: 271 | HGNC ID: HGNC:469 | Ensembl Gene: ENSG00000116337 | OMIM ID: 102771 |
| Drug and gene relationship at DGIdb | |||
Expression of AMPD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AMPD2 | 271 | 212360_at | 0.7995 | 0.0086 | |
| GSE20347 | AMPD2 | 271 | 212360_at | 0.4924 | 0.0000 | |
| GSE23400 | AMPD2 | 271 | 212360_at | 0.3986 | 0.0000 | |
| GSE26886 | AMPD2 | 271 | 212360_at | 1.1871 | 0.0000 | |
| GSE29001 | AMPD2 | 271 | 212360_at | 0.5382 | 0.0497 | |
| GSE38129 | AMPD2 | 271 | 212360_at | 0.4533 | 0.0001 | |
| GSE45670 | AMPD2 | 271 | 212360_at | 0.2568 | 0.1335 | |
| GSE53622 | AMPD2 | 271 | 99518 | 0.5060 | 0.0000 | |
| GSE53624 | AMPD2 | 271 | 99518 | 0.7767 | 0.0000 | |
| GSE63941 | AMPD2 | 271 | 212360_at | -1.3343 | 0.0044 | |
| GSE77861 | AMPD2 | 271 | 212360_at | 0.2671 | 0.0939 | |
| GSE97050 | AMPD2 | 271 | A_23_P201596 | 0.3080 | 0.2151 | |
| SRP007169 | AMPD2 | 271 | RNAseq | 1.7690 | 0.0011 | |
| SRP008496 | AMPD2 | 271 | RNAseq | 1.3397 | 0.0006 | |
| SRP064894 | AMPD2 | 271 | RNAseq | 1.0189 | 0.0000 | |
| SRP133303 | AMPD2 | 271 | RNAseq | 0.5309 | 0.0013 | |
| SRP159526 | AMPD2 | 271 | RNAseq | 0.5324 | 0.1067 | |
| SRP193095 | AMPD2 | 271 | RNAseq | 0.8475 | 0.0000 | |
| SRP219564 | AMPD2 | 271 | RNAseq | 0.8885 | 0.0014 | |
| TCGA | AMPD2 | 271 | RNAseq | 0.1083 | 0.0378 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by AMPD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AMPD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AMPD2 | 271 | 0 | 12 | 18 | |
| GSE20123 | AMPD2 | 271 | 0 | 11 | 19 | |
| GSE43470 | AMPD2 | 271 | 0 | 9 | 34 | |
| GSE46452 | AMPD2 | 271 | 2 | 1 | 56 | |
| GSE47630 | AMPD2 | 271 | 9 | 5 | 26 | |
| GSE54993 | AMPD2 | 271 | 0 | 1 | 69 | |
| GSE54994 | AMPD2 | 271 | 7 | 4 | 42 | |
| GSE60625 | AMPD2 | 271 | 0 | 0 | 11 | |
| GSE74703 | AMPD2 | 271 | 0 | 7 | 29 | |
| GSE74704 | AMPD2 | 271 | 0 | 7 | 13 | |
| TCGA | AMPD2 | 271 | 9 | 26 | 61 |
Total number of gains: 27; Total number of losses: 83; Total Number of normals: 378.
Somatic mutations of AMPD2:
Generating mutation plots.
Highly correlated genes for AMPD2:
Showing top 20/556 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AMPD2 | LRFN3 | 0.807452 | 3 | 0 | 3 |
| AMPD2 | RASGRF2 | 0.765359 | 3 | 0 | 3 |
| AMPD2 | PLEKHG4 | 0.76007 | 3 | 0 | 3 |
| AMPD2 | ZNF77 | 0.753042 | 3 | 0 | 3 |
| AMPD2 | NPW | 0.750516 | 3 | 0 | 3 |
| AMPD2 | ZNF446 | 0.74326 | 4 | 0 | 4 |
| AMPD2 | DNLZ | 0.740392 | 3 | 0 | 3 |
| AMPD2 | TTYH3 | 0.736513 | 6 | 0 | 6 |
| AMPD2 | MOK | 0.734817 | 3 | 0 | 3 |
| AMPD2 | CD276 | 0.731765 | 5 | 0 | 5 |
| AMPD2 | MAGEE1 | 0.727617 | 3 | 0 | 3 |
| AMPD2 | LRFN1 | 0.727251 | 3 | 0 | 3 |
| AMPD2 | PEAR1 | 0.721869 | 3 | 0 | 3 |
| AMPD2 | THAP3 | 0.71914 | 5 | 0 | 5 |
| AMPD2 | DUSP9 | 0.712728 | 6 | 0 | 5 |
| AMPD2 | VEPH1 | 0.708501 | 3 | 0 | 3 |
| AMPD2 | ARID3A | 0.703977 | 5 | 0 | 4 |
| AMPD2 | CHTF18 | 0.700111 | 3 | 0 | 3 |
| AMPD2 | VHL | 0.697338 | 3 | 0 | 3 |
| AMPD2 | EYS | 0.695749 | 3 | 0 | 3 |
For details and further investigation, click here
