RAD21

 

Full name: RAD21 cohesin complex component Alias Symbol: KIAA0078|hHR21|SCC1
Type: protein-coding gene Cytoband: 8q24.11
Entrez ID: 5885 HGNC ID: HGNC:9811 Ensembl Gene: ENSG00000164754 OMIM ID: 606462
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 247/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

RAD21 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle

 

Expression of RAD21:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RAD21 5885 200608_s_at 0.6882 0.0431
GSE20347 RAD21 5885 200608_s_at 1.0400 0.0000
GSE23400 RAD21 5885 200608_s_at 0.9939 0.0000
GSE26886 RAD21 5885 200608_s_at 0.2580 0.1739
GSE29001 RAD21 5885 200608_s_at 0.8611 0.0068
GSE38129 RAD21 5885 200608_s_at 0.7911 0.0000
GSE45670 RAD21 5885 200608_s_at 0.4216 0.0267
GSE63941 RAD21 5885 200608_s_at 0.3893 0.2806
GSE77861 RAD21 5885 200608_s_at 0.7295 0.0073
GSE97050 RAD21 5885 A_23_P20463 0.2054 0.4948
SRP007169 RAD21 5885 RNAseq 0.5033 0.0716
SRP008496 RAD21 5885 RNAseq 0.4579 0.0065
SRP064894 RAD21 5885 RNAseq 0.4613 0.0506
SRP133303 RAD21 5885 RNAseq 0.7552 0.0000
SRP159526 RAD21 5885 RNAseq 0.5085 0.0003
SRP193095 RAD21 5885 RNAseq 0.5151 0.0000
SRP219564 RAD21 5885 RNAseq -0.1024 0.7087
TCGA RAD21 5885 RNAseq 0.1757 0.0001

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by RAD21 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of RAD21:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RAD21 5885 18 1 11
GSE20123 RAD21 5885 19 1 10
GSE43470 RAD21 5885 21 0 22
GSE46452 RAD21 5885 26 0 33
GSE47630 RAD21 5885 24 0 16
GSE54993 RAD21 5885 0 20 50
GSE54994 RAD21 5885 37 1 15
GSE60625 RAD21 5885 0 4 7
GSE74703 RAD21 5885 18 0 18
GSE74704 RAD21 5885 13 1 6
TCGA RAD21 5885 63 2 31

Total number of gains: 239; Total number of losses: 30; Total Number of normals: 219.  

 

Somatic mutations of RAD21:

 

Generating mutation plots.

 

Highly correlated genes for RAD21:

 

Showing top 20/1828 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RAD21CPNE80.907754303
RAD21SMCR80.843407303
RAD21ZNF4510.838809303
RAD21DPY19L40.77977110010
RAD21SEC630.777321303
RAD21PPTC70.77563303
RAD21CCDC1270.772707303
RAD21FZD60.768621009
RAD21KBTBD60.76843404
RAD21TAF20.76805811010
RAD21WDR540.767834303
RAD21SLC25A320.7676151009
RAD21MAP4K30.763422404
RAD21NUDCD10.759335706
RAD21ZNF2840.758433303
RAD21OSBPL90.755413303
RAD21MED300.754668706
RAD21ANP32E0.7541521008
RAD21PTK20.7527711009
RAD21NEDD10.752643505

For details and further investigation, click here