ZNF618

 

Full name: zinc finger protein 618 Alias Symbol: KIAA1952|NEDD10
Type: protein-coding gene Cytoband: 9q32
Entrez ID: 114991 HGNC ID: HGNC:29416 Ensembl Gene: ENSG00000157657 OMIM ID: 617077
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ZNF618:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ZNF618 114991 226592_at 0.9383 0.2115
GSE26886 ZNF618 114991 226590_at 0.9522 0.0045
GSE45670 ZNF618 114991 238444_at 0.2575 0.2077
GSE53622 ZNF618 114991 53260 0.8881 0.0000
GSE53624 ZNF618 114991 53260 1.1036 0.0000
GSE63941 ZNF618 114991 226592_at -0.1152 0.8888
GSE77861 ZNF618 114991 226592_at -0.0933 0.6730
GSE97050 ZNF618 114991 A_33_P3248108 0.5367 0.1417
SRP007169 ZNF618 114991 RNAseq 2.5465 0.0004
SRP008496 ZNF618 114991 RNAseq 3.0636 0.0000
SRP064894 ZNF618 114991 RNAseq 1.1861 0.0000
SRP133303 ZNF618 114991 RNAseq 0.6030 0.0061
SRP159526 ZNF618 114991 RNAseq 1.5680 0.0010
SRP193095 ZNF618 114991 RNAseq 1.0849 0.0000
SRP219564 ZNF618 114991 RNAseq 1.4416 0.0007
TCGA ZNF618 114991 RNAseq 0.0361 0.7564

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by ZNF618 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ZNF618:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ZNF618 114991 4 11 15
GSE20123 ZNF618 114991 4 11 15
GSE43470 ZNF618 114991 4 3 36
GSE46452 ZNF618 114991 6 13 40
GSE47630 ZNF618 114991 3 16 21
GSE54993 ZNF618 114991 3 3 64
GSE54994 ZNF618 114991 9 10 34
GSE60625 ZNF618 114991 0 0 11
GSE74703 ZNF618 114991 4 3 29
GSE74704 ZNF618 114991 2 8 10
TCGA ZNF618 114991 26 22 48

Total number of gains: 65; Total number of losses: 100; Total Number of normals: 323.  

 

Somatic mutations of ZNF618:

 

Generating mutation plots.

 

Highly correlated genes for ZNF618:

 

Showing top 20/566 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ZNF618SLC25A190.736844303
ZNF618CHERP0.735009303
ZNF618RNF2130.733935303
ZNF618KHSRP0.722002403
ZNF618PRKCSH0.712065404
ZNF618LSP10.707539303
ZNF618GORAB0.698408404
ZNF618MIER20.694789303
ZNF618ZNF6280.687019404
ZNF618IFT1220.683347404
ZNF618ZAP700.682383303
ZNF618CIC0.677979303
ZNF618MARCKSL10.677034605
ZNF618MUC160.676916303
ZNF618SYCP2L0.67291303
ZNF618ATXN7L10.666083303
ZNF618ZFYVE270.665838403
ZNF618SF3A20.665441404
ZNF618SLC19A10.664304303
ZNF618MYNN0.662656303

For details and further investigation, click here