| Full name: MARCKS like 1 | Alias Symbol: F52|MacMARCKS|MLP1 | ||
| Type: protein-coding gene | Cytoband: 1p35.1 | ||
| Entrez ID: 65108 | HGNC ID: HGNC:7142 | Ensembl Gene: ENSG00000175130 | OMIM ID: 602940 |
| Drug and gene relationship at DGIdb | |||
MARCKSL1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04666 | Fc gamma R-mediated phagocytosis |
Expression of MARCKSL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MARCKSL1 | 65108 | 200644_at | 1.8268 | 0.0285 | |
| GSE20347 | MARCKSL1 | 65108 | 200644_at | 2.4900 | 0.0000 | |
| GSE23400 | MARCKSL1 | 65108 | 200644_at | 1.4381 | 0.0000 | |
| GSE26886 | MARCKSL1 | 65108 | 200644_at | 1.7867 | 0.0000 | |
| GSE29001 | MARCKSL1 | 65108 | 200644_at | 1.7825 | 0.0002 | |
| GSE38129 | MARCKSL1 | 65108 | 200644_at | 2.2717 | 0.0000 | |
| GSE45670 | MARCKSL1 | 65108 | 200644_at | 1.8801 | 0.0000 | |
| GSE53622 | MARCKSL1 | 65108 | 62270 | 1.9882 | 0.0000 | |
| GSE53624 | MARCKSL1 | 65108 | 62270 | 1.9090 | 0.0000 | |
| GSE63941 | MARCKSL1 | 65108 | 200644_at | -0.7380 | 0.3973 | |
| GSE77861 | MARCKSL1 | 65108 | 200644_at | 2.1167 | 0.0003 | |
| GSE97050 | MARCKSL1 | 65108 | A_23_P310 | 1.6002 | 0.0835 | |
| SRP007169 | MARCKSL1 | 65108 | RNAseq | 2.0754 | 0.0000 | |
| SRP008496 | MARCKSL1 | 65108 | RNAseq | 2.4130 | 0.0000 | |
| SRP064894 | MARCKSL1 | 65108 | RNAseq | 2.5496 | 0.0000 | |
| SRP133303 | MARCKSL1 | 65108 | RNAseq | 1.6075 | 0.0000 | |
| SRP159526 | MARCKSL1 | 65108 | RNAseq | 2.3257 | 0.0003 | |
| SRP193095 | MARCKSL1 | 65108 | RNAseq | 0.4862 | 0.1568 | |
| SRP219564 | MARCKSL1 | 65108 | RNAseq | 2.0057 | 0.0001 | |
| TCGA | MARCKSL1 | 65108 | RNAseq | 0.2414 | 0.0034 |
Upregulated datasets: 16; Downregulated datasets: 0.
Survival by MARCKSL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MARCKSL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MARCKSL1 | 65108 | 1 | 5 | 24 | |
| GSE20123 | MARCKSL1 | 65108 | 1 | 4 | 25 | |
| GSE43470 | MARCKSL1 | 65108 | 6 | 4 | 33 | |
| GSE46452 | MARCKSL1 | 65108 | 5 | 1 | 53 | |
| GSE47630 | MARCKSL1 | 65108 | 8 | 3 | 29 | |
| GSE54993 | MARCKSL1 | 65108 | 1 | 1 | 68 | |
| GSE54994 | MARCKSL1 | 65108 | 11 | 2 | 40 | |
| GSE60625 | MARCKSL1 | 65108 | 0 | 0 | 11 | |
| GSE74703 | MARCKSL1 | 65108 | 3 | 3 | 30 | |
| GSE74704 | MARCKSL1 | 65108 | 0 | 0 | 20 | |
| TCGA | MARCKSL1 | 65108 | 10 | 20 | 66 |
Total number of gains: 46; Total number of losses: 43; Total Number of normals: 399.
Somatic mutations of MARCKSL1:
Generating mutation plots.
Highly correlated genes for MARCKSL1:
Showing top 20/2480 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MARCKSL1 | PDIA5 | 0.820919 | 3 | 0 | 3 |
| MARCKSL1 | DNMT1 | 0.81055 | 11 | 0 | 11 |
| MARCKSL1 | GORAB | 0.799535 | 6 | 0 | 6 |
| MARCKSL1 | PYCR2 | 0.795818 | 3 | 0 | 3 |
| MARCKSL1 | ARPC1B | 0.793488 | 11 | 0 | 11 |
| MARCKSL1 | MCM2 | 0.793054 | 10 | 0 | 10 |
| MARCKSL1 | MCM6 | 0.787696 | 10 | 0 | 10 |
| MARCKSL1 | CD80 | 0.787489 | 3 | 0 | 3 |
| MARCKSL1 | PLXNA1 | 0.782605 | 11 | 0 | 11 |
| MARCKSL1 | SLC39A3 | 0.778521 | 4 | 0 | 4 |
| MARCKSL1 | CLPTM1L | 0.776968 | 6 | 0 | 6 |
| MARCKSL1 | UBE2C | 0.776053 | 11 | 0 | 11 |
| MARCKSL1 | MCM5 | 0.770778 | 9 | 0 | 9 |
| MARCKSL1 | TMTC4 | 0.769745 | 3 | 0 | 3 |
| MARCKSL1 | ADAR | 0.768799 | 11 | 0 | 10 |
| MARCKSL1 | PLAU | 0.767962 | 11 | 0 | 11 |
| MARCKSL1 | SOX4 | 0.767803 | 13 | 0 | 12 |
| MARCKSL1 | LAPTM4B | 0.767551 | 11 | 0 | 11 |
| MARCKSL1 | MCM3 | 0.767276 | 10 | 0 | 10 |
| MARCKSL1 | SNAP47 | 0.765324 | 3 | 0 | 3 |
For details and further investigation, click here
