| Full name: prolyl 4-hydroxylase, transmembrane | Alias Symbol: P4H-TM|PHD4|PH4|HIFPH4|FLJ20262|EGLN4|PH-4 | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 54681 | HGNC ID: HGNC:28858 | Ensembl Gene: ENSG00000178467 | OMIM ID: 614584 |
| Drug and gene relationship at DGIdb | |||
Expression of P4HTM:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | P4HTM | 54681 | 222125_s_at | -0.7022 | 0.1391 | |
| GSE20347 | P4HTM | 54681 | 222125_s_at | -0.4192 | 0.0197 | |
| GSE23400 | P4HTM | 54681 | 222125_s_at | -0.1988 | 0.0011 | |
| GSE26886 | P4HTM | 54681 | 222125_s_at | -0.2857 | 0.2389 | |
| GSE29001 | P4HTM | 54681 | 222125_s_at | -0.4781 | 0.0544 | |
| GSE38129 | P4HTM | 54681 | 222125_s_at | -0.4075 | 0.0124 | |
| GSE45670 | P4HTM | 54681 | 222125_s_at | -0.4471 | 0.0573 | |
| GSE53622 | P4HTM | 54681 | 26302 | -0.6936 | 0.0000 | |
| GSE53624 | P4HTM | 54681 | 26302 | -0.6668 | 0.0000 | |
| GSE63941 | P4HTM | 54681 | 222125_s_at | 0.0871 | 0.9183 | |
| GSE77861 | P4HTM | 54681 | 222125_s_at | 0.1374 | 0.6267 | |
| GSE97050 | P4HTM | 54681 | A_23_P113317 | 0.0449 | 0.8773 | |
| SRP007169 | P4HTM | 54681 | RNAseq | -0.3769 | 0.3740 | |
| SRP008496 | P4HTM | 54681 | RNAseq | -0.2118 | 0.5087 | |
| SRP064894 | P4HTM | 54681 | RNAseq | -0.4146 | 0.0923 | |
| SRP133303 | P4HTM | 54681 | RNAseq | -0.4862 | 0.0855 | |
| SRP159526 | P4HTM | 54681 | RNAseq | -0.0958 | 0.7310 | |
| SRP193095 | P4HTM | 54681 | RNAseq | -0.1693 | 0.4549 | |
| SRP219564 | P4HTM | 54681 | RNAseq | -0.3504 | 0.5096 | |
| TCGA | P4HTM | 54681 | RNAseq | -0.5997 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by P4HTM expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of P4HTM:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | P4HTM | 54681 | 0 | 18 | 12 | |
| GSE20123 | P4HTM | 54681 | 0 | 19 | 11 | |
| GSE43470 | P4HTM | 54681 | 0 | 18 | 25 | |
| GSE46452 | P4HTM | 54681 | 2 | 16 | 41 | |
| GSE47630 | P4HTM | 54681 | 1 | 24 | 15 | |
| GSE54993 | P4HTM | 54681 | 6 | 2 | 62 | |
| GSE54994 | P4HTM | 54681 | 0 | 36 | 17 | |
| GSE60625 | P4HTM | 54681 | 5 | 0 | 6 | |
| GSE74703 | P4HTM | 54681 | 0 | 14 | 22 | |
| GSE74704 | P4HTM | 54681 | 0 | 12 | 8 | |
| TCGA | P4HTM | 54681 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 237; Total Number of normals: 237.
Somatic mutations of P4HTM:
Generating mutation plots.
Highly correlated genes for P4HTM:
Showing top 20/531 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| P4HTM | IDH3G | 0.745081 | 3 | 0 | 3 |
| P4HTM | ABHD14B | 0.74425 | 4 | 0 | 4 |
| P4HTM | VWA1 | 0.741348 | 3 | 0 | 3 |
| P4HTM | ZBED5 | 0.728606 | 3 | 0 | 3 |
| P4HTM | RNLS | 0.72481 | 3 | 0 | 3 |
| P4HTM | ZDHHC2 | 0.719359 | 4 | 0 | 4 |
| P4HTM | DOK6 | 0.716084 | 3 | 0 | 3 |
| P4HTM | TMEM219 | 0.712415 | 4 | 0 | 4 |
| P4HTM | CCDC159 | 0.706017 | 4 | 0 | 4 |
| P4HTM | TUBE1 | 0.705054 | 3 | 0 | 3 |
| P4HTM | ALKBH7 | 0.700889 | 5 | 0 | 5 |
| P4HTM | ECD | 0.699403 | 3 | 0 | 3 |
| P4HTM | GRIK2 | 0.69909 | 3 | 0 | 3 |
| P4HTM | AADAT | 0.698639 | 3 | 0 | 3 |
| P4HTM | PITPNM2 | 0.698131 | 3 | 0 | 3 |
| P4HTM | BBS1 | 0.694377 | 4 | 0 | 3 |
| P4HTM | RAB39B | 0.692195 | 3 | 0 | 3 |
| P4HTM | GATAD1 | 0.691029 | 3 | 0 | 3 |
| P4HTM | FRY | 0.69091 | 5 | 0 | 5 |
| P4HTM | DCTN3 | 0.690273 | 4 | 0 | 3 |
For details and further investigation, click here
