| Full name: chromobox 1 | Alias Symbol: HP1Hs-beta|M31|MOD1|CBX|HP1-BETA | ||
| Type: protein-coding gene | Cytoband: 17q21.32 | ||
| Entrez ID: 10951 | HGNC ID: HGNC:1551 | Ensembl Gene: ENSG00000108468 | OMIM ID: 604511 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CBX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CBX1 | 10951 | 201518_at | 0.2635 | 0.5682 | |
| GSE20347 | CBX1 | 10951 | 201518_at | 0.7237 | 0.0004 | |
| GSE23400 | CBX1 | 10951 | 201518_at | 0.8286 | 0.0000 | |
| GSE26886 | CBX1 | 10951 | 201518_at | 0.4064 | 0.0804 | |
| GSE29001 | CBX1 | 10951 | 201518_at | 0.6299 | 0.0470 | |
| GSE38129 | CBX1 | 10951 | 201518_at | 0.8194 | 0.0000 | |
| GSE45670 | CBX1 | 10951 | 201518_at | 0.2606 | 0.2533 | |
| GSE53622 | CBX1 | 10951 | 149625 | 0.5486 | 0.0000 | |
| GSE53624 | CBX1 | 10951 | 149625 | 0.5689 | 0.0000 | |
| GSE63941 | CBX1 | 10951 | 201518_at | 0.1776 | 0.6979 | |
| GSE77861 | CBX1 | 10951 | 201518_at | 0.5138 | 0.0029 | |
| GSE97050 | CBX1 | 10951 | A_33_P3332006 | 0.1982 | 0.3283 | |
| SRP007169 | CBX1 | 10951 | RNAseq | 1.7881 | 0.0002 | |
| SRP008496 | CBX1 | 10951 | RNAseq | 1.5219 | 0.0000 | |
| SRP064894 | CBX1 | 10951 | RNAseq | 0.4004 | 0.0367 | |
| SRP133303 | CBX1 | 10951 | RNAseq | 0.3984 | 0.0221 | |
| SRP159526 | CBX1 | 10951 | RNAseq | 1.0635 | 0.0000 | |
| SRP193095 | CBX1 | 10951 | RNAseq | 0.4618 | 0.0062 | |
| SRP219564 | CBX1 | 10951 | RNAseq | -0.0357 | 0.8879 | |
| TCGA | CBX1 | 10951 | RNAseq | 0.3421 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by CBX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CBX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CBX1 | 10951 | 5 | 2 | 23 | |
| GSE20123 | CBX1 | 10951 | 5 | 2 | 23 | |
| GSE43470 | CBX1 | 10951 | 2 | 2 | 39 | |
| GSE46452 | CBX1 | 10951 | 32 | 0 | 27 | |
| GSE47630 | CBX1 | 10951 | 9 | 0 | 31 | |
| GSE54993 | CBX1 | 10951 | 2 | 4 | 64 | |
| GSE54994 | CBX1 | 10951 | 11 | 5 | 37 | |
| GSE60625 | CBX1 | 10951 | 4 | 0 | 7 | |
| GSE74703 | CBX1 | 10951 | 2 | 1 | 33 | |
| GSE74704 | CBX1 | 10951 | 4 | 1 | 15 | |
| TCGA | CBX1 | 10951 | 27 | 6 | 63 |
Total number of gains: 103; Total number of losses: 23; Total Number of normals: 362.
Somatic mutations of CBX1:
Generating mutation plots.
Highly correlated genes for CBX1:
Showing top 20/1534 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CBX1 | AAK1 | 0.789259 | 3 | 0 | 3 |
| CBX1 | SMCR8 | 0.768291 | 3 | 0 | 3 |
| CBX1 | NSRP1 | 0.74741 | 3 | 0 | 3 |
| CBX1 | TRAF7 | 0.743149 | 3 | 0 | 3 |
| CBX1 | RAB11FIP5 | 0.737846 | 3 | 0 | 3 |
| CBX1 | EXOSC6 | 0.731072 | 4 | 0 | 4 |
| CBX1 | HSD17B1 | 0.730313 | 3 | 0 | 3 |
| CBX1 | POLR2K | 0.72892 | 4 | 0 | 4 |
| CBX1 | PDE8A | 0.720607 | 3 | 0 | 3 |
| CBX1 | RCN2 | 0.71708 | 9 | 0 | 7 |
| CBX1 | JMY | 0.716049 | 3 | 0 | 3 |
| CBX1 | BMP2 | 0.71595 | 3 | 0 | 3 |
| CBX1 | MKNK1 | 0.712637 | 3 | 0 | 3 |
| CBX1 | MMS22L | 0.711902 | 3 | 0 | 3 |
| CBX1 | ZDHHC7 | 0.710174 | 4 | 0 | 4 |
| CBX1 | KLF13 | 0.70997 | 4 | 0 | 4 |
| CBX1 | MED29 | 0.703917 | 3 | 0 | 3 |
| CBX1 | CASC4 | 0.69535 | 4 | 0 | 4 |
| CBX1 | ILF2 | 0.691139 | 10 | 0 | 9 |
| CBX1 | MSH6 | 0.690795 | 12 | 0 | 11 |
For details and further investigation, click here
