| Full name: aminoadipate-semialdehyde synthase | Alias Symbol: LORSDH|LKRSDH | ||
| Type: protein-coding gene | Cytoband: 7q31.32 | ||
| Entrez ID: 10157 | HGNC ID: HGNC:17366 | Ensembl Gene: ENSG00000008311 | OMIM ID: 605113 |
| Drug and gene relationship at DGIdb | |||
Expression of AASS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AASS | 10157 | 214829_at | -0.6411 | 0.1827 | |
| GSE20347 | AASS | 10157 | 214829_at | -0.2933 | 0.1564 | |
| GSE23400 | AASS | 10157 | 214829_at | -0.1298 | 0.0148 | |
| GSE26886 | AASS | 10157 | 210852_s_at | -0.4079 | 0.1169 | |
| GSE29001 | AASS | 10157 | 214829_at | -0.9211 | 0.0106 | |
| GSE38129 | AASS | 10157 | 214829_at | -0.4807 | 0.0037 | |
| GSE45670 | AASS | 10157 | 210852_s_at | -0.4323 | 0.1531 | |
| GSE53622 | AASS | 10157 | 108714 | -0.3501 | 0.0077 | |
| GSE53624 | AASS | 10157 | 108714 | -0.3138 | 0.0035 | |
| GSE63941 | AASS | 10157 | 214829_at | -1.9655 | 0.0020 | |
| GSE77861 | AASS | 10157 | 214829_at | -0.4270 | 0.1107 | |
| GSE97050 | AASS | 10157 | A_23_P8754 | 0.1734 | 0.3949 | |
| SRP007169 | AASS | 10157 | RNAseq | 0.8944 | 0.1579 | |
| SRP008496 | AASS | 10157 | RNAseq | 0.2316 | 0.5945 | |
| SRP064894 | AASS | 10157 | RNAseq | -0.6194 | 0.0507 | |
| SRP133303 | AASS | 10157 | RNAseq | -0.1439 | 0.5912 | |
| SRP159526 | AASS | 10157 | RNAseq | -0.4143 | 0.2086 | |
| SRP193095 | AASS | 10157 | RNAseq | -0.0944 | 0.6704 | |
| SRP219564 | AASS | 10157 | RNAseq | -0.8903 | 0.0397 | |
| TCGA | AASS | 10157 | RNAseq | -0.3363 | 0.0048 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by AASS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AASS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AASS | 10157 | 7 | 2 | 21 | |
| GSE20123 | AASS | 10157 | 8 | 2 | 20 | |
| GSE43470 | AASS | 10157 | 2 | 4 | 37 | |
| GSE46452 | AASS | 10157 | 8 | 1 | 50 | |
| GSE47630 | AASS | 10157 | 7 | 4 | 29 | |
| GSE54993 | AASS | 10157 | 3 | 5 | 62 | |
| GSE54994 | AASS | 10157 | 10 | 6 | 37 | |
| GSE60625 | AASS | 10157 | 0 | 0 | 11 | |
| GSE74703 | AASS | 10157 | 2 | 4 | 30 | |
| GSE74704 | AASS | 10157 | 5 | 2 | 13 | |
| TCGA | AASS | 10157 | 28 | 20 | 48 |
Total number of gains: 80; Total number of losses: 50; Total Number of normals: 358.
Somatic mutations of AASS:
Generating mutation plots.
Highly correlated genes for AASS:
Showing top 20/215 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AASS | CDC42EP5 | 0.735957 | 3 | 0 | 3 |
| AASS | ZNF804A | 0.675205 | 3 | 0 | 3 |
| AASS | ZRANB1 | 0.651807 | 3 | 0 | 3 |
| AASS | ACVR1B | 0.649238 | 3 | 0 | 3 |
| AASS | CASP9 | 0.64887 | 4 | 0 | 4 |
| AASS | FZD4 | 0.647136 | 3 | 0 | 3 |
| AASS | NIPSNAP3A | 0.643294 | 3 | 0 | 3 |
| AASS | ZNF844 | 0.643279 | 4 | 0 | 4 |
| AASS | CHRDL2 | 0.642744 | 3 | 0 | 3 |
| AASS | EMCN | 0.640941 | 3 | 0 | 3 |
| AASS | PITX1 | 0.639333 | 4 | 0 | 4 |
| AASS | MAP4 | 0.637009 | 3 | 0 | 3 |
| AASS | EEA1 | 0.63607 | 4 | 0 | 4 |
| AASS | ZNF667-AS1 | 0.634056 | 3 | 0 | 3 |
| AASS | CNPPD1 | 0.631687 | 3 | 0 | 3 |
| AASS | ARHGAP31 | 0.630107 | 3 | 0 | 3 |
| AASS | MTERF4 | 0.62689 | 3 | 0 | 3 |
| AASS | SGMS2 | 0.624565 | 4 | 0 | 4 |
| AASS | C4orf33 | 0.623001 | 3 | 0 | 3 |
| AASS | PDE2A | 0.622615 | 3 | 0 | 3 |
For details and further investigation, click here
