| Full name: sphingomyelin synthase 2 | Alias Symbol: MGC26963|SMS2 | ||
| Type: protein-coding gene | Cytoband: 4q25 | ||
| Entrez ID: 166929 | HGNC ID: HGNC:28395 | Ensembl Gene: ENSG00000164023 | OMIM ID: 611574 |
| Drug and gene relationship at DGIdb | |||
Expression of SGMS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SGMS2 | 166929 | 227038_at | -0.8548 | 0.1170 | |
| GSE26886 | SGMS2 | 166929 | 227038_at | -1.8858 | 0.0000 | |
| GSE45670 | SGMS2 | 166929 | 227038_at | -1.0095 | 0.0002 | |
| GSE53622 | SGMS2 | 166929 | 26321 | -1.0417 | 0.0000 | |
| GSE53624 | SGMS2 | 166929 | 26321 | -0.7513 | 0.0000 | |
| GSE63941 | SGMS2 | 166929 | 227038_at | -3.4028 | 0.0007 | |
| GSE77861 | SGMS2 | 166929 | 227038_at | -1.1259 | 0.0055 | |
| GSE97050 | SGMS2 | 166929 | A_23_P326204 | -0.0338 | 0.9163 | |
| SRP007169 | SGMS2 | 166929 | RNAseq | -0.4687 | 0.3019 | |
| SRP008496 | SGMS2 | 166929 | RNAseq | -0.6070 | 0.0082 | |
| SRP064894 | SGMS2 | 166929 | RNAseq | -0.7411 | 0.0107 | |
| SRP133303 | SGMS2 | 166929 | RNAseq | 0.3148 | 0.2350 | |
| SRP159526 | SGMS2 | 166929 | RNAseq | -1.1882 | 0.0339 | |
| SRP193095 | SGMS2 | 166929 | RNAseq | -0.9230 | 0.0000 | |
| SRP219564 | SGMS2 | 166929 | RNAseq | -0.5640 | 0.2016 | |
| TCGA | SGMS2 | 166929 | RNAseq | -0.4465 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by SGMS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SGMS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SGMS2 | 166929 | 0 | 12 | 18 | |
| GSE20123 | SGMS2 | 166929 | 0 | 12 | 18 | |
| GSE43470 | SGMS2 | 166929 | 0 | 13 | 30 | |
| GSE46452 | SGMS2 | 166929 | 1 | 36 | 22 | |
| GSE47630 | SGMS2 | 166929 | 0 | 20 | 20 | |
| GSE54993 | SGMS2 | 166929 | 9 | 0 | 61 | |
| GSE54994 | SGMS2 | 166929 | 1 | 10 | 42 | |
| GSE60625 | SGMS2 | 166929 | 0 | 3 | 8 | |
| GSE74703 | SGMS2 | 166929 | 0 | 11 | 25 | |
| GSE74704 | SGMS2 | 166929 | 0 | 6 | 14 | |
| TCGA | SGMS2 | 166929 | 8 | 35 | 53 |
Total number of gains: 19; Total number of losses: 158; Total Number of normals: 311.
Somatic mutations of SGMS2:
Generating mutation plots.
Highly correlated genes for SGMS2:
Showing top 20/1312 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SGMS2 | LACTB | 0.766453 | 3 | 0 | 3 |
| SGMS2 | RAP1A | 0.763932 | 7 | 0 | 7 |
| SGMS2 | NIPAL3 | 0.76262 | 3 | 0 | 3 |
| SGMS2 | PDCD7 | 0.753286 | 4 | 0 | 4 |
| SGMS2 | PPP2CB | 0.750077 | 6 | 0 | 6 |
| SGMS2 | BCS1L | 0.749969 | 3 | 0 | 3 |
| SGMS2 | SYNE1 | 0.74821 | 4 | 0 | 4 |
| SGMS2 | PDIK1L | 0.745859 | 3 | 0 | 3 |
| SGMS2 | ATF7 | 0.745855 | 3 | 0 | 3 |
| SGMS2 | MBNL3 | 0.744006 | 3 | 0 | 3 |
| SGMS2 | VSTM4 | 0.741892 | 3 | 0 | 3 |
| SGMS2 | CTSS | 0.733879 | 3 | 0 | 3 |
| SGMS2 | RHBDD1 | 0.732739 | 3 | 0 | 3 |
| SGMS2 | BCAS2 | 0.731931 | 3 | 0 | 3 |
| SGMS2 | USP9Y | 0.728692 | 3 | 0 | 3 |
| SGMS2 | HS3ST1 | 0.726156 | 4 | 0 | 4 |
| SGMS2 | JAK1 | 0.724739 | 3 | 0 | 3 |
| SGMS2 | ZNF436 | 0.723415 | 4 | 0 | 4 |
| SGMS2 | DR1 | 0.719939 | 3 | 0 | 3 |
| SGMS2 | DNALI1 | 0.715589 | 4 | 0 | 4 |
For details and further investigation, click here
