| Full name: diacylglycerol O-acyltransferase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q13.5 | ||
| Entrez ID: 84649 | HGNC ID: HGNC:16940 | Ensembl Gene: ENSG00000062282 | OMIM ID: 606983 |
| Drug and gene relationship at DGIdb | |||
Expression of DGAT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DGAT2 | 84649 | 226064_s_at | 0.8209 | 0.4266 | |
| GSE26886 | DGAT2 | 84649 | 224327_s_at | -1.8948 | 0.0000 | |
| GSE45670 | DGAT2 | 84649 | 226064_s_at | -0.1547 | 0.6915 | |
| GSE53622 | DGAT2 | 84649 | 31461 | -0.5938 | 0.0005 | |
| GSE53624 | DGAT2 | 84649 | 31461 | -1.2518 | 0.0000 | |
| GSE63941 | DGAT2 | 84649 | 226064_s_at | 1.1619 | 0.1489 | |
| GSE77861 | DGAT2 | 84649 | 224327_s_at | -0.7911 | 0.0017 | |
| GSE97050 | DGAT2 | 84649 | A_23_P53198 | -0.0046 | 0.9925 | |
| SRP007169 | DGAT2 | 84649 | RNAseq | -5.7549 | 0.0000 | |
| SRP008496 | DGAT2 | 84649 | RNAseq | -3.1948 | 0.0001 | |
| SRP064894 | DGAT2 | 84649 | RNAseq | -1.2919 | 0.0001 | |
| SRP133303 | DGAT2 | 84649 | RNAseq | -1.6748 | 0.0000 | |
| SRP159526 | DGAT2 | 84649 | RNAseq | -1.8505 | 0.0004 | |
| SRP193095 | DGAT2 | 84649 | RNAseq | -1.2608 | 0.0000 | |
| SRP219564 | DGAT2 | 84649 | RNAseq | -0.7821 | 0.4240 | |
| TCGA | DGAT2 | 84649 | RNAseq | -0.0856 | 0.6316 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by DGAT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DGAT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DGAT2 | 84649 | 6 | 8 | 16 | |
| GSE20123 | DGAT2 | 84649 | 6 | 7 | 17 | |
| GSE43470 | DGAT2 | 84649 | 3 | 4 | 36 | |
| GSE46452 | DGAT2 | 84649 | 7 | 22 | 30 | |
| GSE47630 | DGAT2 | 84649 | 7 | 14 | 19 | |
| GSE54993 | DGAT2 | 84649 | 8 | 2 | 60 | |
| GSE54994 | DGAT2 | 84649 | 7 | 17 | 29 | |
| GSE60625 | DGAT2 | 84649 | 4 | 3 | 4 | |
| GSE74703 | DGAT2 | 84649 | 2 | 3 | 31 | |
| GSE74704 | DGAT2 | 84649 | 4 | 3 | 13 | |
| TCGA | DGAT2 | 84649 | 20 | 31 | 45 |
Total number of gains: 74; Total number of losses: 114; Total Number of normals: 300.
Somatic mutations of DGAT2:
Generating mutation plots.
Highly correlated genes for DGAT2:
Showing top 20/429 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DGAT2 | ANKRD22 | 0.777639 | 3 | 0 | 3 |
| DGAT2 | VASH2 | 0.769129 | 3 | 0 | 3 |
| DGAT2 | CLIC3 | 0.756995 | 3 | 0 | 3 |
| DGAT2 | SLC35C1 | 0.747187 | 6 | 0 | 5 |
| DGAT2 | ABAT | 0.724858 | 3 | 0 | 3 |
| DGAT2 | LCORL | 0.720655 | 3 | 0 | 3 |
| DGAT2 | PRSS2 | 0.719243 | 4 | 0 | 4 |
| DGAT2 | ENDOU | 0.708475 | 5 | 0 | 4 |
| DGAT2 | SH2D1B | 0.707645 | 3 | 0 | 3 |
| DGAT2 | SFTA2 | 0.706102 | 3 | 0 | 3 |
| DGAT2 | PCBP1-AS1 | 0.70592 | 3 | 0 | 3 |
| DGAT2 | PTK6 | 0.704643 | 6 | 0 | 5 |
| DGAT2 | CXCR2 | 0.704419 | 5 | 0 | 5 |
| DGAT2 | DLK2 | 0.703647 | 3 | 0 | 3 |
| DGAT2 | CDC42BPB | 0.703227 | 3 | 0 | 3 |
| DGAT2 | P4HB | 0.702436 | 3 | 0 | 3 |
| DGAT2 | GDPD3 | 0.702328 | 5 | 0 | 4 |
| DGAT2 | IQCD | 0.700842 | 3 | 0 | 3 |
| DGAT2 | RAET1E | 0.700277 | 6 | 0 | 5 |
| DGAT2 | MAPK3 | 0.69829 | 5 | 0 | 5 |
For details and further investigation, click here
