ABCA1

 

Full name: ATP binding cassette subfamily A member 1 Alias Symbol: TGD
Type: protein-coding gene Cytoband: 9q31.1
Entrez ID: 19 HGNC ID: HGNC:29 Ensembl Gene: ENSG00000165029 OMIM ID: 600046
Drug and gene relationship at DGIdb

 

Expression of ABCA1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ABCA1 19 203505_at 0.7629 0.2611
GSE20347 ABCA1 19 203505_at 0.6149 0.0275
GSE23400 ABCA1 19 203505_at 0.4937 0.0000
GSE26886 ABCA1 19 203505_at 0.5989 0.0130
GSE29001 ABCA1 19 203505_at 0.7971 0.0032
GSE38129 ABCA1 19 203505_at 0.4664 0.0194
GSE45670 ABCA1 19 203505_at 0.4960 0.0388
GSE53622 ABCA1 19 101227 0.9766 0.0000
GSE53624 ABCA1 19 10528 0.7781 0.0000
GSE63941 ABCA1 19 203505_at -2.4942 0.0424
GSE77861 ABCA1 19 203505_at 0.6689 0.0509
GSE97050 ABCA1 19 A_33_P3422897 0.3281 0.2937
SRP007169 ABCA1 19 RNAseq 2.9125 0.0000
SRP008496 ABCA1 19 RNAseq 2.5124 0.0000
SRP064894 ABCA1 19 RNAseq 1.2574 0.0001
SRP133303 ABCA1 19 RNAseq 1.0718 0.0001
SRP159526 ABCA1 19 RNAseq 0.9233 0.0315
SRP193095 ABCA1 19 RNAseq 1.3143 0.0000
SRP219564 ABCA1 19 RNAseq 0.5554 0.1183
TCGA ABCA1 19 RNAseq 0.2175 0.0136

Upregulated datasets: 5; Downregulated datasets: 1.  

 

Survival by ABCA1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ABCA1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ABCA1 19 4 10 16
GSE20123 ABCA1 19 5 9 16
GSE43470 ABCA1 19 7 3 33
GSE46452 ABCA1 19 6 13 40
GSE47630 ABCA1 19 1 17 22
GSE54993 ABCA1 19 3 3 64
GSE54994 ABCA1 19 9 10 34
GSE60625 ABCA1 19 0 0 11
GSE74703 ABCA1 19 6 3 27
GSE74704 ABCA1 19 2 6 12
TCGA ABCA1 19 26 21 49

Total number of gains: 69; Total number of losses: 95; Total Number of normals: 324.  

 

Somatic mutations of ABCA1:

 

Generating mutation plots.

 

Highly correlated genes for ABCA1:

 

Showing top 20/902 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ABCA1LRRC8C0.739477303
ABCA1HNRNPUL10.73056303
ABCA1CEP1700.702768303
ABCA1GNG100.698472303
ABCA1RNF19A0.694844404
ABCA1FNDC10.686038404
ABCA1IMMP1L0.680058303
ABCA1RUNX30.672371605
ABCA1KCNAB20.671121504
ABCA1TAF4B0.667968303
ABCA1TRAM10.667639403
ABCA1FUCA20.665408505
ABCA1ARHGAP180.665142404
ABCA1VKORC10.663125303
ABCA1WDR810.662553504
ABCA1TREM20.653393404
ABCA1HSP90B10.651145605
ABCA1IFNGR10.649431909
ABCA1CEP630.648898303
ABCA1FCER1G0.647624707

For details and further investigation, click here