| Full name: RUNX family transcription factor 3 | Alias Symbol: AML2|PEBP2A3 | ||
| Type: protein-coding gene | Cytoband: 1p36.11 | ||
| Entrez ID: 864 | HGNC ID: HGNC:10473 | Ensembl Gene: ENSG00000020633 | OMIM ID: 600210 |
| Drug and gene relationship at DGIdb | |||
Expression of RUNX3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RUNX3 | 864 | 204197_s_at | 0.8595 | 0.2968 | |
| GSE20347 | RUNX3 | 864 | 204197_s_at | 0.9570 | 0.0002 | |
| GSE23400 | RUNX3 | 864 | 204197_s_at | 0.3658 | 0.0000 | |
| GSE26886 | RUNX3 | 864 | 204197_s_at | 1.5046 | 0.0058 | |
| GSE29001 | RUNX3 | 864 | 204197_s_at | 1.0167 | 0.0015 | |
| GSE38129 | RUNX3 | 864 | 204197_s_at | 1.0513 | 0.0000 | |
| GSE45670 | RUNX3 | 864 | 204197_s_at | 0.6576 | 0.0011 | |
| GSE53622 | RUNX3 | 864 | 156032 | 0.8828 | 0.0000 | |
| GSE53624 | RUNX3 | 864 | 34604 | 0.7324 | 0.0000 | |
| GSE63941 | RUNX3 | 864 | 204197_s_at | 2.1553 | 0.0271 | |
| GSE77861 | RUNX3 | 864 | 204197_s_at | 0.4969 | 0.0178 | |
| GSE97050 | RUNX3 | 864 | A_33_P3221748 | 0.5476 | 0.2516 | |
| SRP007169 | RUNX3 | 864 | RNAseq | 1.0354 | 0.1547 | |
| SRP008496 | RUNX3 | 864 | RNAseq | 0.8555 | 0.0724 | |
| SRP064894 | RUNX3 | 864 | RNAseq | 0.7248 | 0.0118 | |
| SRP133303 | RUNX3 | 864 | RNAseq | 0.3756 | 0.1624 | |
| SRP159526 | RUNX3 | 864 | RNAseq | 1.1938 | 0.0321 | |
| SRP193095 | RUNX3 | 864 | RNAseq | 0.9537 | 0.0000 | |
| SRP219564 | RUNX3 | 864 | RNAseq | 1.1885 | 0.0497 | |
| TCGA | RUNX3 | 864 | RNAseq | 0.8139 | 0.0000 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by RUNX3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RUNX3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RUNX3 | 864 | 0 | 5 | 25 | |
| GSE20123 | RUNX3 | 864 | 0 | 4 | 26 | |
| GSE43470 | RUNX3 | 864 | 2 | 6 | 35 | |
| GSE46452 | RUNX3 | 864 | 5 | 1 | 53 | |
| GSE47630 | RUNX3 | 864 | 8 | 3 | 29 | |
| GSE54993 | RUNX3 | 864 | 2 | 1 | 67 | |
| GSE54994 | RUNX3 | 864 | 11 | 4 | 38 | |
| GSE60625 | RUNX3 | 864 | 0 | 0 | 11 | |
| GSE74703 | RUNX3 | 864 | 1 | 4 | 31 | |
| GSE74704 | RUNX3 | 864 | 0 | 0 | 20 | |
| TCGA | RUNX3 | 864 | 10 | 23 | 63 |
Total number of gains: 39; Total number of losses: 51; Total Number of normals: 398.
Somatic mutations of RUNX3:
Generating mutation plots.
Highly correlated genes for RUNX3:
Showing top 20/1366 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RUNX3 | PREX1 | 0.810101 | 3 | 0 | 3 |
| RUNX3 | CYP27C1 | 0.751979 | 3 | 0 | 3 |
| RUNX3 | TMEM216 | 0.74927 | 3 | 0 | 3 |
| RUNX3 | NUP35 | 0.732024 | 3 | 0 | 3 |
| RUNX3 | C1orf162 | 0.728144 | 3 | 0 | 3 |
| RUNX3 | DHRSX | 0.727407 | 4 | 0 | 4 |
| RUNX3 | LRRK1 | 0.727127 | 3 | 0 | 3 |
| RUNX3 | FAM102B | 0.725436 | 3 | 0 | 3 |
| RUNX3 | CLPTM1L | 0.713711 | 6 | 0 | 6 |
| RUNX3 | HIBADH | 0.711433 | 3 | 0 | 3 |
| RUNX3 | STEAP1B | 0.708894 | 3 | 0 | 3 |
| RUNX3 | WDR81 | 0.708433 | 4 | 0 | 4 |
| RUNX3 | EME1 | 0.707015 | 3 | 0 | 3 |
| RUNX3 | TMEM138 | 0.706023 | 6 | 0 | 5 |
| RUNX3 | OAF | 0.705833 | 3 | 0 | 3 |
| RUNX3 | SUCNR1 | 0.701868 | 3 | 0 | 3 |
| RUNX3 | OSGIN2 | 0.695049 | 3 | 0 | 3 |
| RUNX3 | TMTC4 | 0.694273 | 4 | 0 | 4 |
| RUNX3 | ZNF251 | 0.692513 | 3 | 0 | 3 |
| RUNX3 | CDH13 | 0.691687 | 3 | 0 | 3 |
For details and further investigation, click here
