| Full name: vitamin K epoxide reductase complex subunit 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 79001 | HGNC ID: HGNC:23663 | Ensembl Gene: ENSG00000167397 | OMIM ID: 608547 |
| Drug and gene relationship at DGIdb | |||
Expression of VKORC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VKORC1 | 79001 | 217949_s_at | 0.1044 | 0.8880 | |
| GSE20347 | VKORC1 | 79001 | 217949_s_at | 0.4636 | 0.0318 | |
| GSE23400 | VKORC1 | 79001 | 217949_s_at | 0.3270 | 0.0000 | |
| GSE26886 | VKORC1 | 79001 | 217949_s_at | 0.1281 | 0.5202 | |
| GSE29001 | VKORC1 | 79001 | 217949_s_at | 0.5648 | 0.2272 | |
| GSE38129 | VKORC1 | 79001 | 217949_s_at | 0.3382 | 0.1778 | |
| GSE45670 | VKORC1 | 79001 | 217949_s_at | -0.0212 | 0.9443 | |
| GSE53622 | VKORC1 | 79001 | 54398 | 0.7524 | 0.0000 | |
| GSE53624 | VKORC1 | 79001 | 54398 | 0.8504 | 0.0000 | |
| GSE63941 | VKORC1 | 79001 | 217949_s_at | -1.3852 | 0.0075 | |
| GSE77861 | VKORC1 | 79001 | 217949_s_at | 0.3433 | 0.3036 | |
| GSE97050 | VKORC1 | 79001 | A_23_P100486 | 0.2989 | 0.2764 | |
| SRP007169 | VKORC1 | 79001 | RNAseq | 0.5990 | 0.1192 | |
| SRP008496 | VKORC1 | 79001 | RNAseq | 0.7960 | 0.0045 | |
| SRP064894 | VKORC1 | 79001 | RNAseq | 0.8298 | 0.0374 | |
| SRP133303 | VKORC1 | 79001 | RNAseq | 0.7045 | 0.0019 | |
| SRP159526 | VKORC1 | 79001 | RNAseq | 0.7008 | 0.0365 | |
| SRP193095 | VKORC1 | 79001 | RNAseq | 0.4061 | 0.0024 | |
| SRP219564 | VKORC1 | 79001 | RNAseq | 0.4907 | 0.3248 | |
| TCGA | VKORC1 | 79001 | RNAseq | 0.0176 | 0.7734 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by VKORC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VKORC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VKORC1 | 79001 | 5 | 5 | 20 | |
| GSE20123 | VKORC1 | 79001 | 5 | 4 | 21 | |
| GSE43470 | VKORC1 | 79001 | 3 | 3 | 37 | |
| GSE46452 | VKORC1 | 79001 | 38 | 1 | 20 | |
| GSE47630 | VKORC1 | 79001 | 11 | 7 | 22 | |
| GSE54993 | VKORC1 | 79001 | 2 | 5 | 63 | |
| GSE54994 | VKORC1 | 79001 | 5 | 9 | 39 | |
| GSE60625 | VKORC1 | 79001 | 4 | 0 | 7 | |
| GSE74703 | VKORC1 | 79001 | 3 | 2 | 31 | |
| GSE74704 | VKORC1 | 79001 | 3 | 2 | 15 | |
| TCGA | VKORC1 | 79001 | 20 | 10 | 66 |
Total number of gains: 99; Total number of losses: 48; Total Number of normals: 341.
Somatic mutations of VKORC1:
Generating mutation plots.
Highly correlated genes for VKORC1:
Showing top 20/1476 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VKORC1 | RAB34 | 0.833556 | 3 | 0 | 3 |
| VKORC1 | PFKP | 0.755961 | 3 | 0 | 3 |
| VKORC1 | SLC35B2 | 0.754627 | 3 | 0 | 3 |
| VKORC1 | FCGR3A | 0.751048 | 3 | 0 | 3 |
| VKORC1 | SPON2 | 0.748349 | 3 | 0 | 3 |
| VKORC1 | PDIA5 | 0.747763 | 3 | 0 | 3 |
| VKORC1 | LRRC8C | 0.745601 | 3 | 0 | 3 |
| VKORC1 | GXYLT2 | 0.73123 | 5 | 0 | 5 |
| VKORC1 | AP1M1 | 0.729037 | 5 | 0 | 5 |
| VKORC1 | TLK2 | 0.723787 | 3 | 0 | 3 |
| VKORC1 | PYCR2 | 0.723581 | 3 | 0 | 3 |
| VKORC1 | FNDC1 | 0.723384 | 7 | 0 | 7 |
| VKORC1 | FADS1 | 0.723189 | 3 | 0 | 3 |
| VKORC1 | ZNF275 | 0.721593 | 5 | 0 | 4 |
| VKORC1 | ZDHHC4 | 0.718032 | 7 | 0 | 6 |
| VKORC1 | CEP170 | 0.715885 | 3 | 0 | 3 |
| VKORC1 | DOCK7 | 0.712642 | 6 | 0 | 5 |
| VKORC1 | CLEC14A | 0.70613 | 3 | 0 | 3 |
| VKORC1 | STARD3NL | 0.705266 | 5 | 0 | 5 |
| VKORC1 | SNAP47 | 0.70131 | 3 | 0 | 3 |
For details and further investigation, click here
