| Full name: ATP binding cassette subfamily B member 11 | Alias Symbol: ABC16|SPGP|PFIC-2|PGY4 | ||
| Type: protein-coding gene | Cytoband: 2q31.1 | ||
| Entrez ID: 8647 | HGNC ID: HGNC:42 | Ensembl Gene: ENSG00000073734 | OMIM ID: 603201 |
| Drug and gene relationship at DGIdb | |||
ABCB11 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04976 | Bile secretion |
Expression of ABCB11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABCB11 | 8647 | 211224_s_at | 0.1483 | 0.5509 | |
| GSE20347 | ABCB11 | 8647 | 211224_s_at | -0.0320 | 0.7287 | |
| GSE23400 | ABCB11 | 8647 | 211224_s_at | -0.1543 | 0.0000 | |
| GSE26886 | ABCB11 | 8647 | 211224_s_at | -0.1546 | 0.0885 | |
| GSE29001 | ABCB11 | 8647 | 211224_s_at | -0.0240 | 0.8695 | |
| GSE38129 | ABCB11 | 8647 | 211224_s_at | -0.0689 | 0.2599 | |
| GSE45670 | ABCB11 | 8647 | 211224_s_at | 0.1050 | 0.2153 | |
| GSE53622 | ABCB11 | 8647 | 129059 | 0.1835 | 0.2724 | |
| GSE53624 | ABCB11 | 8647 | 129059 | -0.3578 | 0.0011 | |
| GSE63941 | ABCB11 | 8647 | 211224_s_at | 0.1205 | 0.3923 | |
| GSE77861 | ABCB11 | 8647 | 211224_s_at | -0.1125 | 0.1780 | |
| TCGA | ABCB11 | 8647 | RNAseq | -0.2578 | 0.7597 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ABCB11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABCB11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABCB11 | 8647 | 6 | 0 | 24 | |
| GSE20123 | ABCB11 | 8647 | 6 | 0 | 24 | |
| GSE43470 | ABCB11 | 8647 | 5 | 1 | 37 | |
| GSE46452 | ABCB11 | 8647 | 1 | 4 | 54 | |
| GSE47630 | ABCB11 | 8647 | 5 | 3 | 32 | |
| GSE54993 | ABCB11 | 8647 | 0 | 5 | 65 | |
| GSE54994 | ABCB11 | 8647 | 11 | 2 | 40 | |
| GSE60625 | ABCB11 | 8647 | 0 | 3 | 8 | |
| GSE74703 | ABCB11 | 8647 | 4 | 1 | 31 | |
| GSE74704 | ABCB11 | 8647 | 3 | 0 | 17 | |
| TCGA | ABCB11 | 8647 | 24 | 10 | 62 |
Total number of gains: 65; Total number of losses: 29; Total Number of normals: 394.
Somatic mutations of ABCB11:
Generating mutation plots.
Highly correlated genes for ABCB11:
Showing top 20/548 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABCB11 | ACSBG1 | 0.698422 | 3 | 0 | 3 |
| ABCB11 | CPA2 | 0.692871 | 4 | 0 | 4 |
| ABCB11 | KLHL4 | 0.687477 | 3 | 0 | 3 |
| ABCB11 | CCDC87 | 0.686497 | 4 | 0 | 4 |
| ABCB11 | CYP19A1 | 0.683075 | 4 | 0 | 4 |
| ABCB11 | CRP | 0.663015 | 4 | 0 | 4 |
| ABCB11 | SERPINA6 | 0.660546 | 5 | 0 | 5 |
| ABCB11 | ADAM18 | 0.646398 | 4 | 0 | 4 |
| ABCB11 | CYP2D6 | 0.64547 | 6 | 0 | 5 |
| ABCB11 | FCN2 | 0.645174 | 4 | 0 | 4 |
| ABCB11 | RNF185-AS1 | 0.644017 | 4 | 0 | 4 |
| ABCB11 | OR3A1 | 0.64152 | 4 | 0 | 3 |
| ABCB11 | PPP1R14D | 0.640209 | 4 | 0 | 4 |
| ABCB11 | CMKLR1 | 0.640197 | 3 | 0 | 3 |
| ABCB11 | HPX | 0.639589 | 4 | 0 | 4 |
| ABCB11 | GHSR | 0.637671 | 3 | 0 | 3 |
| ABCB11 | KRTAP5-8 | 0.637295 | 6 | 0 | 6 |
| ABCB11 | CGA | 0.636001 | 4 | 0 | 3 |
| ABCB11 | PSG9 | 0.634441 | 3 | 0 | 3 |
| ABCB11 | AKAP7 | 0.632737 | 3 | 0 | 3 |
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