| Full name: ATP binding cassette subfamily C member 3 | Alias Symbol: MRP3|cMOAT2|EST90757|MLP2|MOAT-D | ||
| Type: protein-coding gene | Cytoband: 17q21.33 | ||
| Entrez ID: 8714 | HGNC ID: HGNC:54 | Ensembl Gene: ENSG00000108846 | OMIM ID: 604323 |
| Drug and gene relationship at DGIdb | |||
Expression of ABCC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABCC3 | 8714 | 208161_s_at | -0.7955 | 0.3679 | |
| GSE20347 | ABCC3 | 8714 | 208161_s_at | -0.2408 | 0.4517 | |
| GSE23400 | ABCC3 | 8714 | 209641_s_at | 0.2398 | 0.0161 | |
| GSE26886 | ABCC3 | 8714 | 208161_s_at | 0.8808 | 0.1034 | |
| GSE29001 | ABCC3 | 8714 | 208161_s_at | -0.9275 | 0.0377 | |
| GSE38129 | ABCC3 | 8714 | 208161_s_at | 0.0501 | 0.8902 | |
| GSE45670 | ABCC3 | 8714 | 208161_s_at | -0.0400 | 0.9324 | |
| GSE53622 | ABCC3 | 8714 | 30370 | -0.0484 | 0.8632 | |
| GSE53624 | ABCC3 | 8714 | 30370 | -0.3357 | 0.0432 | |
| GSE63941 | ABCC3 | 8714 | 208161_s_at | -0.2261 | 0.8172 | |
| GSE77861 | ABCC3 | 8714 | 208161_s_at | 0.3641 | 0.4736 | |
| GSE97050 | ABCC3 | 8714 | A_23_P207507 | 0.1257 | 0.6520 | |
| SRP007169 | ABCC3 | 8714 | RNAseq | 1.1897 | 0.0072 | |
| SRP064894 | ABCC3 | 8714 | RNAseq | -0.5213 | 0.1021 | |
| SRP133303 | ABCC3 | 8714 | RNAseq | -1.0152 | 0.0009 | |
| SRP159526 | ABCC3 | 8714 | RNAseq | 0.1004 | 0.8646 | |
| SRP193095 | ABCC3 | 8714 | RNAseq | -0.5468 | 0.1497 | |
| SRP219564 | ABCC3 | 8714 | RNAseq | -0.8957 | 0.3542 | |
| TCGA | ABCC3 | 8714 | RNAseq | -0.3336 | 0.0802 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by ABCC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABCC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABCC3 | 8714 | 5 | 2 | 23 | |
| GSE20123 | ABCC3 | 8714 | 5 | 2 | 23 | |
| GSE43470 | ABCC3 | 8714 | 3 | 2 | 38 | |
| GSE46452 | ABCC3 | 8714 | 32 | 0 | 27 | |
| GSE47630 | ABCC3 | 8714 | 9 | 0 | 31 | |
| GSE54993 | ABCC3 | 8714 | 2 | 4 | 64 | |
| GSE54994 | ABCC3 | 8714 | 9 | 6 | 38 | |
| GSE60625 | ABCC3 | 8714 | 4 | 0 | 7 | |
| GSE74703 | ABCC3 | 8714 | 3 | 2 | 31 | |
| GSE74704 | ABCC3 | 8714 | 4 | 1 | 15 | |
| TCGA | ABCC3 | 8714 | 26 | 8 | 62 |
Total number of gains: 102; Total number of losses: 27; Total Number of normals: 359.
Somatic mutations of ABCC3:
Generating mutation plots.
Highly correlated genes for ABCC3:
Showing top 20/71 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABCC3 | NQO1 | 0.654339 | 10 | 0 | 9 |
| ABCC3 | AKR1B15 | 0.636493 | 4 | 0 | 4 |
| ABCC3 | SRXN1 | 0.635691 | 6 | 0 | 5 |
| ABCC3 | PPP1R14D | 0.635577 | 3 | 0 | 3 |
| ABCC3 | PHYHIP | 0.627616 | 3 | 0 | 3 |
| ABCC3 | AKR1B10 | 0.622342 | 12 | 0 | 9 |
| ABCC3 | CYP4F3 | 0.622031 | 11 | 0 | 10 |
| ABCC3 | CYP4F11 | 0.619172 | 12 | 0 | 10 |
| ABCC3 | CACNG4 | 0.618599 | 3 | 0 | 3 |
| ABCC3 | THEG | 0.616829 | 3 | 0 | 3 |
| ABCC3 | RGR | 0.613408 | 3 | 0 | 3 |
| ABCC3 | CYP4F2 | 0.611406 | 12 | 0 | 10 |
| ABCC3 | CYP4F12 | 0.606569 | 7 | 0 | 5 |
| ABCC3 | SCGB2B2 | 0.606188 | 3 | 0 | 3 |
| ABCC3 | SULT2B1 | 0.604497 | 4 | 0 | 3 |
| ABCC3 | PDPN | 0.60448 | 3 | 0 | 3 |
| ABCC3 | CYP4F8 | 0.604426 | 4 | 0 | 3 |
| ABCC3 | C2orf81 | 0.600354 | 3 | 0 | 3 |
| ABCC3 | AKR1C3 | 0.599189 | 11 | 0 | 10 |
| ABCC3 | MAMLD1 | 0.595424 | 4 | 0 | 3 |
For details and further investigation, click here
