| Full name: aldo-keto reductase family 1 member B15 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q33 | ||
| Entrez ID: 441282 | HGNC ID: HGNC:37281 | Ensembl Gene: ENSG00000227471 | OMIM ID: 616336 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of AKR1B15:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | AKR1B15 | 441282 | 103104 | -0.5022 | 0.1652 | |
| GSE53624 | AKR1B15 | 441282 | 103104 | -0.4990 | 0.0172 | |
| GSE97050 | AKR1B15 | 441282 | A_33_P3380992 | 0.5451 | 0.1840 | |
| SRP007169 | AKR1B15 | 441282 | RNAseq | 0.3421 | 0.5937 | |
| SRP008496 | AKR1B15 | 441282 | RNAseq | 1.2992 | 0.0883 | |
| SRP064894 | AKR1B15 | 441282 | RNAseq | 1.3924 | 0.0000 | |
| SRP133303 | AKR1B15 | 441282 | RNAseq | 0.1753 | 0.1242 | |
| SRP159526 | AKR1B15 | 441282 | RNAseq | 1.7612 | 0.0115 | |
| SRP193095 | AKR1B15 | 441282 | RNAseq | 0.3674 | 0.0385 | |
| TCGA | AKR1B15 | 441282 | RNAseq | 1.4598 | 0.0001 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by AKR1B15 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AKR1B15:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKR1B15 | 441282 | 6 | 2 | 22 | |
| GSE20123 | AKR1B15 | 441282 | 6 | 2 | 22 | |
| GSE43470 | AKR1B15 | 441282 | 2 | 3 | 38 | |
| GSE46452 | AKR1B15 | 441282 | 7 | 2 | 50 | |
| GSE47630 | AKR1B15 | 441282 | 7 | 4 | 29 | |
| GSE54993 | AKR1B15 | 441282 | 3 | 5 | 62 | |
| GSE54994 | AKR1B15 | 441282 | 6 | 8 | 39 | |
| GSE60625 | AKR1B15 | 441282 | 0 | 0 | 11 | |
| GSE74703 | AKR1B15 | 441282 | 2 | 3 | 31 | |
| GSE74704 | AKR1B15 | 441282 | 2 | 2 | 16 | |
| TCGA | AKR1B15 | 441282 | 28 | 23 | 45 |
Total number of gains: 69; Total number of losses: 54; Total Number of normals: 365.
Somatic mutations of AKR1B15:
Generating mutation plots.
Highly correlated genes for AKR1B15:
Showing top 20/26 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKR1B15 | AKR1B10 | 0.938095 | 4 | 0 | 4 |
| AKR1B15 | CBR1 | 0.698874 | 3 | 0 | 3 |
| AKR1B15 | CYP4F8 | 0.658971 | 3 | 0 | 3 |
| AKR1B15 | CYP4F3 | 0.652677 | 3 | 0 | 3 |
| AKR1B15 | CYP4F12 | 0.643467 | 4 | 0 | 3 |
| AKR1B15 | KLF5 | 0.641972 | 3 | 0 | 3 |
| AKR1B15 | AKR1C4 | 0.639033 | 3 | 0 | 3 |
| AKR1B15 | TMPRSS4 | 0.637492 | 4 | 0 | 4 |
| AKR1B15 | ABCC3 | 0.636493 | 4 | 0 | 4 |
| AKR1B15 | CYP4F11 | 0.629044 | 3 | 0 | 3 |
| AKR1B15 | CBR3 | 0.624049 | 4 | 0 | 4 |
| AKR1B15 | PRDX1 | 0.623812 | 4 | 0 | 4 |
| AKR1B15 | OSGIN1 | 0.618777 | 3 | 0 | 3 |
| AKR1B15 | AKR1C3 | 0.618558 | 4 | 0 | 4 |
| AKR1B15 | CYP4F2 | 0.615921 | 4 | 0 | 3 |
| AKR1B15 | ADH7 | 0.611525 | 4 | 0 | 4 |
| AKR1B15 | PGD | 0.604387 | 4 | 0 | 4 |
| AKR1B15 | GPX2 | 0.59649 | 4 | 0 | 4 |
| AKR1B15 | FAM83F | 0.586851 | 3 | 0 | 3 |
| AKR1B15 | TXN | 0.582509 | 3 | 0 | 3 |
For details and further investigation, click here
