| Full name: aldo-keto reductase family 1 member B10 | Alias Symbol: AKR1B12|ARL-1|HIS|ARL1|HSI|ALDRLn | ||
| Type: protein-coding gene | Cytoband: 7q33 | ||
| Entrez ID: 57016 | HGNC ID: HGNC:382 | Ensembl Gene: ENSG00000198074 | OMIM ID: 604707 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of AKR1B10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKR1B10 | 57016 | 206561_s_at | -1.3572 | 0.5432 | |
| GSE20347 | AKR1B10 | 57016 | 206561_s_at | -0.4985 | 0.3930 | |
| GSE23400 | AKR1B10 | 57016 | 206561_s_at | 0.1214 | 0.7327 | |
| GSE26886 | AKR1B10 | 57016 | 206561_s_at | -1.7544 | 0.0038 | |
| GSE29001 | AKR1B10 | 57016 | 206561_s_at | -0.9256 | 0.2177 | |
| GSE38129 | AKR1B10 | 57016 | 206561_s_at | 0.1554 | 0.8578 | |
| GSE45670 | AKR1B10 | 57016 | 206561_s_at | 1.4453 | 0.0003 | |
| GSE53622 | AKR1B10 | 57016 | 96897 | -0.6462 | 0.0985 | |
| GSE53624 | AKR1B10 | 57016 | 96897 | -0.7788 | 0.0006 | |
| GSE63941 | AKR1B10 | 57016 | 206561_s_at | 0.4633 | 0.8700 | |
| GSE77861 | AKR1B10 | 57016 | 206561_s_at | 0.3334 | 0.7781 | |
| GSE97050 | AKR1B10 | 57016 | A_24_P129341 | 0.6498 | 0.3403 | |
| SRP007169 | AKR1B10 | 57016 | RNAseq | 0.1771 | 0.8085 | |
| SRP008496 | AKR1B10 | 57016 | RNAseq | 0.9306 | 0.2657 | |
| SRP064894 | AKR1B10 | 57016 | RNAseq | -0.2508 | 0.6826 | |
| SRP133303 | AKR1B10 | 57016 | RNAseq | -0.4712 | 0.3121 | |
| SRP159526 | AKR1B10 | 57016 | RNAseq | 1.8963 | 0.0885 | |
| SRP193095 | AKR1B10 | 57016 | RNAseq | -0.4433 | 0.3118 | |
| SRP219564 | AKR1B10 | 57016 | RNAseq | -0.4000 | 0.7227 | |
| TCGA | AKR1B10 | 57016 | RNAseq | -0.1118 | 0.7294 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by AKR1B10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AKR1B10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKR1B10 | 57016 | 6 | 2 | 22 | |
| GSE20123 | AKR1B10 | 57016 | 6 | 2 | 22 | |
| GSE43470 | AKR1B10 | 57016 | 2 | 3 | 38 | |
| GSE46452 | AKR1B10 | 57016 | 7 | 2 | 50 | |
| GSE47630 | AKR1B10 | 57016 | 7 | 4 | 29 | |
| GSE54993 | AKR1B10 | 57016 | 3 | 5 | 62 | |
| GSE54994 | AKR1B10 | 57016 | 6 | 8 | 39 | |
| GSE60625 | AKR1B10 | 57016 | 0 | 0 | 11 | |
| GSE74703 | AKR1B10 | 57016 | 2 | 3 | 31 | |
| GSE74704 | AKR1B10 | 57016 | 2 | 2 | 16 | |
| TCGA | AKR1B10 | 57016 | 28 | 23 | 45 |
Total number of gains: 69; Total number of losses: 54; Total Number of normals: 365.
Somatic mutations of AKR1B10:
Generating mutation plots.
Highly correlated genes for AKR1B10:
Showing top 20/198 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKR1B10 | AKR1B15 | 0.938095 | 4 | 0 | 4 |
| AKR1B10 | CYP4F3 | 0.702597 | 11 | 0 | 11 |
| AKR1B10 | AKR1C1 | 0.700913 | 10 | 0 | 10 |
| AKR1B10 | AKR1C3 | 0.695044 | 12 | 0 | 12 |
| AKR1B10 | AKR1C2 | 0.685399 | 10 | 0 | 9 |
| AKR1B10 | ALDH3A1 | 0.683685 | 11 | 0 | 11 |
| AKR1B10 | GJB2 | 0.676505 | 4 | 0 | 3 |
| AKR1B10 | MCTS1 | 0.666455 | 4 | 0 | 4 |
| AKR1B10 | DND1 | 0.666346 | 4 | 0 | 3 |
| AKR1B10 | CYP4F2 | 0.655545 | 11 | 0 | 10 |
| AKR1B10 | HUS1 | 0.654893 | 3 | 0 | 3 |
| AKR1B10 | SRXN1 | 0.647995 | 6 | 0 | 6 |
| AKR1B10 | STAP2 | 0.647018 | 3 | 0 | 3 |
| AKR1B10 | NQO1 | 0.643412 | 11 | 0 | 9 |
| AKR1B10 | ADH7 | 0.635458 | 12 | 0 | 11 |
| AKR1B10 | ABCC3 | 0.622342 | 12 | 0 | 9 |
| AKR1B10 | GJB6 | 0.619859 | 6 | 0 | 5 |
| AKR1B10 | CYP4F11 | 0.617045 | 11 | 0 | 10 |
| AKR1B10 | SBSN | 0.616879 | 5 | 0 | 3 |
| AKR1B10 | DKK4 | 0.615723 | 3 | 0 | 3 |
For details and further investigation, click here
