AKR1C3

 

Full name: aldo-keto reductase family 1 member C3 Alias Symbol: KIAA0119|DDX|HAKRB|PGFS
Type: protein-coding gene Cytoband: 10p15.1
Entrez ID: 8644 HGNC ID: HGNC:386 Ensembl Gene: ENSG00000196139 OMIM ID: 603966
Drug and gene relationship at DGIdb

 

AKR1C3 involved pathways:

KEGG pathway Description View
hsa04913Ovarian steroidogenesis

 

Expression of AKR1C3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 AKR1C3 8644 209160_at 0.1924 0.9561
GSE20347 AKR1C3 8644 209160_at 1.2147 0.1285
GSE23400 AKR1C3 8644 209160_at 0.8956 0.0264
GSE26886 AKR1C3 8644 209160_at 1.1495 0.1990
GSE29001 AKR1C3 8644 209160_at 0.3077 0.7792
GSE38129 AKR1C3 8644 209160_at 0.9861 0.1378
GSE45670 AKR1C3 8644 209160_at 0.9707 0.2047
GSE53622 AKR1C3 8644 11745 0.7199 0.0178
GSE53624 AKR1C3 8644 11745 1.1029 0.0000
GSE63941 AKR1C3 8644 209160_at -0.5853 0.8530
GSE77861 AKR1C3 8644 209160_at 1.0837 0.4509
GSE97050 AKR1C3 8644 A_23_P138541 0.4726 0.3749
SRP007169 AKR1C3 8644 RNAseq 1.9605 0.0106
SRP008496 AKR1C3 8644 RNAseq 2.1225 0.0041
SRP064894 AKR1C3 8644 RNAseq 0.5586 0.2101
SRP133303 AKR1C3 8644 RNAseq 0.3478 0.5034
SRP159526 AKR1C3 8644 RNAseq 3.8544 0.0000
SRP193095 AKR1C3 8644 RNAseq 0.4581 0.3401
TCGA AKR1C3 8644 RNAseq 0.0321 0.9104

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by AKR1C3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of AKR1C3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 AKR1C3 8644 6 7 17
GSE20123 AKR1C3 8644 6 6 18
GSE43470 AKR1C3 8644 4 6 33
GSE46452 AKR1C3 8644 2 14 43
GSE47630 AKR1C3 8644 6 14 20
GSE54993 AKR1C3 8644 11 0 59
GSE54994 AKR1C3 8644 4 10 39
GSE60625 AKR1C3 8644 0 0 11
GSE74703 AKR1C3 8644 2 4 30
GSE74704 AKR1C3 8644 1 5 14
TCGA AKR1C3 8644 21 25 50

Total number of gains: 63; Total number of losses: 91; Total Number of normals: 334.  

 

Somatic mutations of AKR1C3:

 

Generating mutation plots.

 

Highly correlated genes for AKR1C3:

 

Showing top 20/96 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
AKR1C3AKR1C20.91045910010
AKR1C3AKR1C10.88872412012
AKR1C3AKR1C40.73871612011
AKR1C3CYP4F110.69835311010
AKR1C3AKR1B100.69504412012
AKR1C3NQO10.68450411011
AKR1C3SRXN10.680924707
AKR1C3G6PD0.6796311011
AKR1C3GPX20.66681513012
AKR1C3SLC7A110.63466913010
AKR1C3SPRR2G0.630969303
AKR1C3TSPAN70.62154912010
AKR1C3GCLM0.6187341009
AKR1C3AKR1B150.618558404
AKR1C3TXNRD10.61321712010
AKR1C3FOXE10.6108791109
AKR1C3ATRAID0.609559303
AKR1C3RMI20.608462303
AKR1C3CYP4F20.60726911010
AKR1C3GCLC0.6069491109

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