| Full name: adrenoceptor alpha 1B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q33.3 | ||
| Entrez ID: 147 | HGNC ID: HGNC:278 | Ensembl Gene: ENSG00000170214 | OMIM ID: 104220 |
| Drug and gene relationship at DGIdb | |||
ADRA1B involved pathways:
Expression of ADRA1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADRA1B | 147 | 207589_at | -0.0287 | 0.9402 | |
| GSE20347 | ADRA1B | 147 | 207589_at | -0.0311 | 0.5790 | |
| GSE23400 | ADRA1B | 147 | 207589_at | -0.0381 | 0.1001 | |
| GSE26886 | ADRA1B | 147 | 207589_at | 0.0466 | 0.7344 | |
| GSE29001 | ADRA1B | 147 | 207589_at | -0.0412 | 0.7793 | |
| GSE38129 | ADRA1B | 147 | 207589_at | -0.0816 | 0.0343 | |
| GSE45670 | ADRA1B | 147 | 207589_at | 0.1035 | 0.1653 | |
| GSE63941 | ADRA1B | 147 | 207589_at | 0.1117 | 0.5218 | |
| GSE77861 | ADRA1B | 147 | 207589_at | 0.0410 | 0.6852 | |
| GSE97050 | ADRA1B | 147 | A_23_P33326 | -0.1507 | 0.5722 | |
| SRP219564 | ADRA1B | 147 | RNAseq | 1.9498 | 0.0191 | |
| TCGA | ADRA1B | 147 | RNAseq | 0.0499 | 0.9262 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ADRA1B expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ADRA1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADRA1B | 147 | 0 | 11 | 19 | |
| GSE20123 | ADRA1B | 147 | 0 | 11 | 19 | |
| GSE43470 | ADRA1B | 147 | 2 | 10 | 31 | |
| GSE46452 | ADRA1B | 147 | 0 | 27 | 32 | |
| GSE47630 | ADRA1B | 147 | 0 | 20 | 20 | |
| GSE54993 | ADRA1B | 147 | 9 | 2 | 59 | |
| GSE54994 | ADRA1B | 147 | 1 | 16 | 36 | |
| GSE60625 | ADRA1B | 147 | 0 | 0 | 11 | |
| GSE74703 | ADRA1B | 147 | 2 | 8 | 26 | |
| GSE74704 | ADRA1B | 147 | 0 | 6 | 14 | |
| TCGA | ADRA1B | 147 | 4 | 37 | 55 |
Total number of gains: 18; Total number of losses: 148; Total Number of normals: 322.
Somatic mutations of ADRA1B:
Generating mutation plots.
Highly correlated genes for ADRA1B:
Showing top 20/332 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADRA1B | NTNG2 | 0.772434 | 3 | 0 | 3 |
| ADRA1B | SHANK1 | 0.721485 | 3 | 0 | 3 |
| ADRA1B | DOK7 | 0.717745 | 3 | 0 | 3 |
| ADRA1B | C22orf39 | 0.712556 | 3 | 0 | 3 |
| ADRA1B | PHOSPHO1 | 0.709471 | 3 | 0 | 3 |
| ADRA1B | AQP8 | 0.695946 | 3 | 0 | 3 |
| ADRA1B | CCDC130 | 0.692485 | 3 | 0 | 3 |
| ADRA1B | TTR | 0.691487 | 3 | 0 | 3 |
| ADRA1B | EFNB1 | 0.688784 | 3 | 0 | 3 |
| ADRA1B | ZNF524 | 0.685445 | 3 | 0 | 3 |
| ADRA1B | E2F1 | 0.684984 | 3 | 0 | 3 |
| ADRA1B | PPP1R27 | 0.681487 | 3 | 0 | 3 |
| ADRA1B | KCTD19 | 0.678908 | 3 | 0 | 3 |
| ADRA1B | RAX2 | 0.677748 | 3 | 0 | 3 |
| ADRA1B | IGSF9B | 0.67227 | 5 | 0 | 4 |
| ADRA1B | SP7 | 0.672005 | 4 | 0 | 3 |
| ADRA1B | OTOP2 | 0.668612 | 3 | 0 | 3 |
| ADRA1B | EFNA2 | 0.666736 | 4 | 0 | 4 |
| ADRA1B | AANAT | 0.659707 | 4 | 0 | 3 |
| ADRA1B | FRMPD1 | 0.658222 | 4 | 0 | 3 |
For details and further investigation, click here
