ABL2

 

Full name: ABL proto-oncogene 2, non-receptor tyrosine kinase Alias Symbol: ARG
Type: protein-coding gene Cytoband: 1q25.2
Entrez ID: 27 HGNC ID: HGNC:77 Ensembl Gene: ENSG00000143322 OMIM ID: 164690
Drug and gene relationship at DGIdb

 

ABL2 involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway

 

Expression of ABL2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ABL2 27 226893_at 1.0456 0.0102
GSE20347 ABL2 27 206411_s_at 0.4519 0.0015
GSE23400 ABL2 27 206411_s_at 0.1407 0.0060
GSE26886 ABL2 27 226893_at 1.5126 0.0000
GSE29001 ABL2 27 206411_s_at 0.0344 0.8227
GSE38129 ABL2 27 206411_s_at 0.3638 0.0047
GSE45670 ABL2 27 231907_at 0.4160 0.1695
GSE53622 ABL2 27 58248 0.8833 0.0000
GSE53624 ABL2 27 58248 1.3901 0.0000
GSE63941 ABL2 27 226893_at -1.6835 0.0013
GSE77861 ABL2 27 226893_at 0.8390 0.0024
GSE97050 ABL2 27 A_33_P3413671 0.9967 0.0631
SRP007169 ABL2 27 RNAseq 1.9803 0.0000
SRP008496 ABL2 27 RNAseq 2.4475 0.0000
SRP064894 ABL2 27 RNAseq 1.2298 0.0000
SRP133303 ABL2 27 RNAseq 1.3905 0.0000
SRP159526 ABL2 27 RNAseq 1.0623 0.0004
SRP193095 ABL2 27 RNAseq 1.8417 0.0000
SRP219564 ABL2 27 RNAseq 1.5854 0.0022
TCGA ABL2 27 RNAseq 0.1034 0.0685

Upregulated datasets: 10; Downregulated datasets: 1.  

 

Survival by ABL2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ABL2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ABL2 27 12 0 18
GSE20123 ABL2 27 12 0 18
GSE43470 ABL2 27 9 1 33
GSE46452 ABL2 27 3 1 55
GSE47630 ABL2 27 14 0 26
GSE54993 ABL2 27 0 6 64
GSE54994 ABL2 27 15 0 38
GSE60625 ABL2 27 0 0 11
GSE74703 ABL2 27 8 1 27
GSE74704 ABL2 27 5 0 15
TCGA ABL2 27 40 3 53

Total number of gains: 118; Total number of losses: 12; Total Number of normals: 358.  

 

Somatic mutations of ABL2:

 

Generating mutation plots.

 

Highly correlated genes for ABL2:

 

Showing top 20/1517 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ABL2CD2000.783046303
ABL2PLEKHM30.78257303
ABL2FADS10.771272303
ABL2FAM89A0.769532303
ABL2RBM15B0.766838303
ABL2FCGR3A0.763722303
ABL2KTI120.760389303
ABL2SLC41A10.75845808
ABL2RAB340.755839303
ABL2ZNF2810.75384910010
ABL2PYCR20.748702303
ABL2SH3RF30.746262404
ABL2FMNL20.742914808
ABL2TK20.742753303
ABL2PTPN40.741924404
ABL2GGNBP20.741546404
ABL2XPR10.739208707
ABL2TRIB10.736467303
ABL2TMEM2630.736056606
ABL2SLC39A30.73518404

For details and further investigation, click here