ZNF281

 

Full name: zinc finger protein 281 Alias Symbol: ZBP-99
Type: protein-coding gene Cytoband: 1q32.1
Entrez ID: 23528 HGNC ID: HGNC:13075 Ensembl Gene: ENSG00000162702 OMIM ID: 
Drug and gene relationship at DGIdb

 

Expression of ZNF281:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ZNF281 23528 222619_at 1.1443 0.0323
GSE20347 ZNF281 23528 218401_s_at 0.9085 0.0000
GSE23400 ZNF281 23528 218401_s_at 0.4748 0.0000
GSE26886 ZNF281 23528 228785_at 1.9556 0.0000
GSE29001 ZNF281 23528 218401_s_at 1.2240 0.0002
GSE38129 ZNF281 23528 218401_s_at 1.0253 0.0004
GSE45670 ZNF281 23528 228785_at 0.8527 0.0024
GSE53622 ZNF281 23528 87579 1.3252 0.0000
GSE53624 ZNF281 23528 87579 1.4081 0.0000
GSE63941 ZNF281 23528 228785_at -1.1478 0.0160
GSE77861 ZNF281 23528 222619_at 1.6193 0.0015
GSE97050 ZNF281 23528 A_23_P311087 0.8715 0.0938
SRP007169 ZNF281 23528 RNAseq 1.6535 0.0000
SRP008496 ZNF281 23528 RNAseq 1.7826 0.0000
SRP064894 ZNF281 23528 RNAseq 1.4588 0.0000
SRP133303 ZNF281 23528 RNAseq 1.5446 0.0000
SRP159526 ZNF281 23528 RNAseq 1.1868 0.0003
SRP193095 ZNF281 23528 RNAseq 1.1851 0.0000
SRP219564 ZNF281 23528 RNAseq 1.3877 0.0032
TCGA ZNF281 23528 RNAseq 0.0521 0.4410

Upregulated datasets: 14; Downregulated datasets: 1.  

 

Survival by ZNF281 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ZNF281:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ZNF281 23528 10 0 20
GSE20123 ZNF281 23528 10 0 20
GSE43470 ZNF281 23528 6 0 37
GSE46452 ZNF281 23528 3 1 55
GSE47630 ZNF281 23528 14 0 26
GSE54993 ZNF281 23528 0 6 64
GSE54994 ZNF281 23528 15 0 38
GSE60625 ZNF281 23528 0 0 11
GSE74703 ZNF281 23528 6 0 30
GSE74704 ZNF281 23528 4 0 16
TCGA ZNF281 23528 42 4 50

Total number of gains: 110; Total number of losses: 11; Total Number of normals: 367.  

 

Somatic mutations of ZNF281:

 

Generating mutation plots.

 

Highly correlated genes for ZNF281:

 

Showing top 20/1997 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ZNF281PYCR20.830769303
ZNF281WDR540.801095606
ZNF281FMNL20.788266808
ZNF281FCGR3A0.786973303
ZNF281NEDD10.785503707
ZNF281RAB340.785109303
ZNF281TMEM2630.774864707
ZNF281LPCAT10.77067311011
ZNF281MET0.767755909
ZNF281FAM89A0.767225303
ZNF281SLC25A320.76594511010
ZNF281CEP1700.765943303
ZNF281GORAB0.757992707
ZNF281SIX40.757989707
ZNF281MARCKSL10.75723711010
ZNF281MINPP10.75495712011
ZNF281ABL20.75384910010
ZNF281ARPC1B0.75318911010
ZNF281NF10.753014303
ZNF281PLAU0.75142611010

For details and further investigation, click here