PRKACB

 

Full name: protein kinase cAMP-activated catalytic subunit beta Alias Symbol: PKACb
Type: protein-coding gene Cytoband: 1p31.1
Entrez ID: 5567 HGNC ID: HGNC:9381 Ensembl Gene: ENSG00000142875 OMIM ID: 176892
Drug and gene relationship at DGIdb

 

PRKACB involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04020Calcium signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04114Oocyte meiosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04340Hedgehog signaling pathway
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04740Olfactory transduction
hsa04742Taste transduction
hsa04750Inflammatory mediator regulation of TRP channels
hsa04910Insulin signaling pathway
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04962Vasopressin-regulated water reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04976Bile secretion
hsa05012Parkinson's disease
hsa05020Prion diseases
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05032Morphine addiction
hsa05110Vibrio cholerae infection
hsa05166HTLV-I infection
hsa05205Proteoglycans in cancer

 

Expression of PRKACB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKACB 5567 202741_at -0.5472 0.4331
GSE20347 PRKACB 5567 202741_at -0.6505 0.0194
GSE23400 PRKACB 5567 202741_at -0.2899 0.0255
GSE26886 PRKACB 5567 202741_at -0.0703 0.8855
GSE29001 PRKACB 5567 202741_at -0.5967 0.1646
GSE38129 PRKACB 5567 202741_at -0.8554 0.0006
GSE45670 PRKACB 5567 202741_at -0.6376 0.0074
GSE53622 PRKACB 5567 49300 -0.5652 0.0000
GSE53624 PRKACB 5567 49300 -0.3861 0.0000
GSE63941 PRKACB 5567 202741_at -1.5020 0.1748
GSE77861 PRKACB 5567 202741_at -0.4986 0.2495
GSE97050 PRKACB 5567 A_33_P3772996 -0.5481 0.2385
SRP007169 PRKACB 5567 RNAseq -1.4305 0.0033
SRP008496 PRKACB 5567 RNAseq -0.7250 0.0130
SRP064894 PRKACB 5567 RNAseq -0.0881 0.6994
SRP133303 PRKACB 5567 RNAseq -0.1875 0.4563
SRP159526 PRKACB 5567 RNAseq -0.6539 0.0013
SRP193095 PRKACB 5567 RNAseq -0.7034 0.0013
SRP219564 PRKACB 5567 RNAseq -0.3636 0.4809
TCGA PRKACB 5567 RNAseq -0.5626 0.0000

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by PRKACB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKACB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKACB 5567 0 8 22
GSE20123 PRKACB 5567 0 8 22
GSE43470 PRKACB 5567 2 2 39
GSE46452 PRKACB 5567 0 1 58
GSE47630 PRKACB 5567 8 5 27
GSE54993 PRKACB 5567 0 0 70
GSE54994 PRKACB 5567 6 3 44
GSE60625 PRKACB 5567 0 0 11
GSE74703 PRKACB 5567 1 2 33
GSE74704 PRKACB 5567 0 5 15
TCGA PRKACB 5567 8 24 64

Total number of gains: 25; Total number of losses: 58; Total Number of normals: 405.  

 

Somatic mutations of PRKACB:

 

Generating mutation plots.

 

Highly correlated genes for PRKACB:

 

Showing top 20/963 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKACBSMTN0.750725505
PRKACBPARVA0.747513807
PRKACBZNF5460.745216303
PRKACBKIAA13280.732633303
PRKACBSSC5D0.730792303
PRKACBMFF0.73046404
PRKACBANXA60.725743606
PRKACBASB50.721522404
PRKACBANAPC160.720493303
PRKACBLMBRD20.720492303
PRKACBMIER10.719601403
PRKACBRBM180.719059303
PRKACBCD340.71699606
PRKACBFAM124A0.71687303
PRKACBREEP20.714548303
PRKACBZNF5700.714169303
PRKACBJMY0.710988403
PRKACBSPOP0.710624606
PRKACBACAT10.707079505
PRKACBRASSF30.703982403

For details and further investigation, click here