| Full name: serine and arginine rich splicing factor 8 | Alias Symbol: SRP46 | ||
| Type: protein-coding gene | Cytoband: 11q21 | ||
| Entrez ID: 10929 | HGNC ID: HGNC:16988 | Ensembl Gene: ENSG00000263465 | OMIM ID: 603269 |
| Drug and gene relationship at DGIdb | |||
SRSF8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05168 | Herpes simplex infection |
Expression of SRSF8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRSF8 | 10929 | 214789_x_at | -0.0500 | 0.8405 | |
| GSE20347 | SRSF8 | 10929 | 214789_x_at | 0.0845 | 0.6070 | |
| GSE23400 | SRSF8 | 10929 | 214789_x_at | 0.1976 | 0.0004 | |
| GSE26886 | SRSF8 | 10929 | 214789_x_at | -0.4530 | 0.0145 | |
| GSE29001 | SRSF8 | 10929 | 214789_x_at | 0.0679 | 0.7517 | |
| GSE38129 | SRSF8 | 10929 | 214789_x_at | 0.0928 | 0.3915 | |
| GSE45670 | SRSF8 | 10929 | 214789_x_at | -0.0718 | 0.6511 | |
| GSE53622 | SRSF8 | 10929 | 58030 | -0.8253 | 0.0000 | |
| GSE53624 | SRSF8 | 10929 | 157858 | -0.6655 | 0.0000 | |
| GSE63941 | SRSF8 | 10929 | 214789_x_at | 0.1521 | 0.6967 | |
| GSE77861 | SRSF8 | 10929 | 214789_x_at | -0.0579 | 0.7796 | |
| GSE97050 | SRSF8 | 10929 | A_32_P17635 | -0.6139 | 0.0970 | |
| SRP007169 | SRSF8 | 10929 | RNAseq | -0.8497 | 0.0436 | |
| SRP008496 | SRSF8 | 10929 | RNAseq | -0.2945 | 0.2722 | |
| SRP064894 | SRSF8 | 10929 | RNAseq | -0.4534 | 0.0012 | |
| SRP133303 | SRSF8 | 10929 | RNAseq | -0.6169 | 0.0002 | |
| SRP159526 | SRSF8 | 10929 | RNAseq | -0.1892 | 0.6218 | |
| SRP193095 | SRSF8 | 10929 | RNAseq | -0.7590 | 0.0000 | |
| SRP219564 | SRSF8 | 10929 | RNAseq | -0.4810 | 0.0945 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SRSF8 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SRSF8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRSF8 | 10929 | 3 | 8 | 19 | |
| GSE20123 | SRSF8 | 10929 | 3 | 8 | 19 | |
| GSE43470 | SRSF8 | 10929 | 2 | 5 | 36 | |
| GSE46452 | SRSF8 | 10929 | 5 | 24 | 30 | |
| GSE47630 | SRSF8 | 10929 | 2 | 19 | 19 | |
| GSE54993 | SRSF8 | 10929 | 8 | 2 | 60 | |
| GSE54994 | SRSF8 | 10929 | 6 | 18 | 29 | |
| GSE60625 | SRSF8 | 10929 | 0 | 3 | 8 | |
| GSE74703 | SRSF8 | 10929 | 1 | 4 | 31 | |
| GSE74704 | SRSF8 | 10929 | 3 | 4 | 13 | |
| TCGA | SRSF8 | 10929 | 11 | 43 | 42 |
Total number of gains: 44; Total number of losses: 138; Total Number of normals: 306.
Somatic mutations of SRSF8:
Generating mutation plots.
Highly correlated genes for SRSF8:
Showing top 20/506 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRSF8 | TTC23 | 0.776287 | 3 | 0 | 3 |
| SRSF8 | TMEM41B | 0.76834 | 3 | 0 | 3 |
| SRSF8 | NACA2 | 0.762404 | 3 | 0 | 3 |
| SRSF8 | GPANK1 | 0.762092 | 3 | 0 | 3 |
| SRSF8 | ZNF480 | 0.760464 | 3 | 0 | 3 |
| SRSF8 | DENND4C | 0.743663 | 4 | 0 | 4 |
| SRSF8 | ZFX | 0.739002 | 3 | 0 | 3 |
| SRSF8 | MRPL35 | 0.736967 | 3 | 0 | 3 |
| SRSF8 | OGFRL1 | 0.729366 | 3 | 0 | 3 |
| SRSF8 | ACAT1 | 0.728099 | 4 | 0 | 4 |
| SRSF8 | AK3 | 0.724962 | 4 | 0 | 4 |
| SRSF8 | PRKAR2A | 0.722627 | 4 | 0 | 3 |
| SRSF8 | CCDC6 | 0.719925 | 5 | 0 | 5 |
| SRSF8 | NDUFS3 | 0.712494 | 4 | 0 | 4 |
| SRSF8 | CGGBP1 | 0.704877 | 4 | 0 | 3 |
| SRSF8 | RPS9 | 0.704735 | 3 | 0 | 3 |
| SRSF8 | C1QTNF7 | 0.70427 | 3 | 0 | 3 |
| SRSF8 | RNPC3 | 0.704209 | 3 | 0 | 3 |
| SRSF8 | TADA2B | 0.703582 | 4 | 0 | 4 |
| SRSF8 | IP6K1 | 0.701816 | 3 | 0 | 3 |
For details and further investigation, click here
