CREB3

 

Full name: cAMP responsive element binding protein 3 Alias Symbol: LZIP|Luman|sLZIP
Type: protein-coding gene Cytoband: 9p13.3
Entrez ID: 10488 HGNC ID: HGNC:2347 Ensembl Gene: ENSG00000107175 OMIM ID: 606443
Drug and gene relationship at DGIdb

 

CREB3 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04668TNF signaling pathway
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04911Insulin secretion
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04922Glucagon signaling pathway
hsa04925Aldosterone synthesis and secretion
hsa04931Insulin resistance
hsa04962Vasopressin-regulated water reabsorption
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa05161Hepatitis B
hsa05215Prostate cancer

 

Expression of CREB3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CREB3 10488 209432_s_at -0.0970 0.8780
GSE20347 CREB3 10488 209432_s_at 0.0033 0.9832
GSE23400 CREB3 10488 209432_s_at -0.0355 0.5413
GSE26886 CREB3 10488 209432_s_at 0.0099 0.9669
GSE29001 CREB3 10488 209432_s_at 0.1808 0.3243
GSE38129 CREB3 10488 209432_s_at -0.0491 0.7899
GSE45670 CREB3 10488 209432_s_at 0.0103 0.9680
GSE53622 CREB3 10488 19992 0.0748 0.3822
GSE53624 CREB3 10488 19992 0.2556 0.0105
GSE63941 CREB3 10488 209432_s_at -0.5515 0.2948
GSE77861 CREB3 10488 209432_s_at -0.1640 0.2035
GSE97050 CREB3 10488 A_23_P423389 -0.0044 0.9875
SRP007169 CREB3 10488 RNAseq -0.1611 0.7265
SRP008496 CREB3 10488 RNAseq 0.4819 0.1404
SRP064894 CREB3 10488 RNAseq 0.3101 0.2845
SRP133303 CREB3 10488 RNAseq 0.1535 0.3684
SRP159526 CREB3 10488 RNAseq -0.1117 0.6390
SRP193095 CREB3 10488 RNAseq 0.3180 0.1567
SRP219564 CREB3 10488 RNAseq 0.6360 0.3005
TCGA CREB3 10488 RNAseq -0.1984 0.0017

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CREB3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CREB3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CREB3 10488 3 12 15
GSE20123 CREB3 10488 3 12 15
GSE43470 CREB3 10488 3 10 30
GSE46452 CREB3 10488 6 15 38
GSE47630 CREB3 10488 1 20 19
GSE54993 CREB3 10488 6 0 64
GSE54994 CREB3 10488 5 12 36
GSE60625 CREB3 10488 0 0 11
GSE74703 CREB3 10488 2 7 27
GSE74704 CREB3 10488 0 10 10
TCGA CREB3 10488 17 44 35

Total number of gains: 46; Total number of losses: 142; Total Number of normals: 300.  

 

Somatic mutations of CREB3:

 

Generating mutation plots.

 

Highly correlated genes for CREB3:

 

Showing top 20/696 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CREB3ACO20.778903303
CREB3DMD0.772061303
CREB3CHID10.772057303
CREB3FAM122C0.771175303
CREB3TERF20.765248303
CREB3WWTR10.763341303
CREB3TCTN30.758072303
CREB3AKT30.748345403
CREB3GSPT20.741603303
CREB3PACSIN20.739249403
CREB3DCHS10.722764403
CREB3RBMX20.718065403
CREB3DOCK70.709365504
CREB3FUNDC20.709024504
CREB3CXorf40B0.707724403
CREB3CNTLN0.706514404
CREB3JTB0.705343303
CREB3BCHE0.705106303
CREB3CBX60.704686403
CREB3CLEC14A0.703888403

For details and further investigation, click here