| Full name: translocase of outer mitochondrial membrane 22 | Alias Symbol: TOM22 | ||
| Type: protein-coding gene | Cytoband: 22q13.1 | ||
| Entrez ID: 56993 | HGNC ID: HGNC:18002 | Ensembl Gene: ENSG00000100216 | OMIM ID: 607046 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TOMM22:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TOMM22 | 56993 | 222474_s_at | 0.1509 | 0.6758 | |
| GSE20347 | TOMM22 | 56993 | 217960_s_at | 0.1143 | 0.3792 | |
| GSE23400 | TOMM22 | 56993 | 217960_s_at | 0.1682 | 0.0044 | |
| GSE26886 | TOMM22 | 56993 | 222474_s_at | -1.0423 | 0.0015 | |
| GSE29001 | TOMM22 | 56993 | 217960_s_at | 0.0436 | 0.7604 | |
| GSE38129 | TOMM22 | 56993 | 217960_s_at | 0.3808 | 0.0362 | |
| GSE45670 | TOMM22 | 56993 | 222474_s_at | 0.1925 | 0.2604 | |
| GSE53622 | TOMM22 | 56993 | 31075 | 0.1094 | 0.0381 | |
| GSE53624 | TOMM22 | 56993 | 31075 | 0.2290 | 0.0222 | |
| GSE63941 | TOMM22 | 56993 | 222474_s_at | 0.2429 | 0.5786 | |
| GSE77861 | TOMM22 | 56993 | 217960_s_at | 0.2389 | 0.5704 | |
| GSE97050 | TOMM22 | 56993 | A_23_P80336 | 0.2222 | 0.3094 | |
| SRP007169 | TOMM22 | 56993 | RNAseq | 0.2268 | 0.6584 | |
| SRP008496 | TOMM22 | 56993 | RNAseq | 0.2195 | 0.5830 | |
| SRP064894 | TOMM22 | 56993 | RNAseq | 0.1646 | 0.4889 | |
| SRP133303 | TOMM22 | 56993 | RNAseq | 0.2087 | 0.1953 | |
| SRP159526 | TOMM22 | 56993 | RNAseq | 0.4344 | 0.0700 | |
| SRP193095 | TOMM22 | 56993 | RNAseq | -0.2413 | 0.0899 | |
| SRP219564 | TOMM22 | 56993 | RNAseq | 0.2647 | 0.4253 | |
| TCGA | TOMM22 | 56993 | RNAseq | 0.1812 | 0.0009 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TOMM22 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TOMM22:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TOMM22 | 56993 | 6 | 5 | 19 | |
| GSE20123 | TOMM22 | 56993 | 6 | 4 | 20 | |
| GSE43470 | TOMM22 | 56993 | 5 | 5 | 33 | |
| GSE46452 | TOMM22 | 56993 | 32 | 2 | 25 | |
| GSE47630 | TOMM22 | 56993 | 9 | 4 | 27 | |
| GSE54993 | TOMM22 | 56993 | 3 | 6 | 61 | |
| GSE54994 | TOMM22 | 56993 | 9 | 7 | 37 | |
| GSE60625 | TOMM22 | 56993 | 5 | 0 | 6 | |
| GSE74703 | TOMM22 | 56993 | 5 | 4 | 27 | |
| GSE74704 | TOMM22 | 56993 | 3 | 2 | 15 | |
| TCGA | TOMM22 | 56993 | 27 | 15 | 54 |
Total number of gains: 110; Total number of losses: 54; Total Number of normals: 324.
Somatic mutations of TOMM22:
Generating mutation plots.
Highly correlated genes for TOMM22:
Showing top 20/487 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TOMM22 | FEM1A | 0.762438 | 3 | 0 | 3 |
| TOMM22 | DHX57 | 0.761153 | 3 | 0 | 3 |
| TOMM22 | SWAP70 | 0.741207 | 3 | 0 | 3 |
| TOMM22 | ATP6V0B | 0.724618 | 5 | 0 | 4 |
| TOMM22 | UBL7 | 0.711757 | 3 | 0 | 3 |
| TOMM22 | SLC24A1 | 0.711039 | 3 | 0 | 3 |
| TOMM22 | PIGM | 0.710057 | 3 | 0 | 3 |
| TOMM22 | VPS18 | 0.707646 | 3 | 0 | 3 |
| TOMM22 | ZFPL1 | 0.707334 | 4 | 0 | 3 |
| TOMM22 | ACO2 | 0.703972 | 6 | 0 | 5 |
| TOMM22 | SPATA2 | 0.700852 | 3 | 0 | 3 |
| TOMM22 | SNRNP40 | 0.69915 | 7 | 0 | 7 |
| TOMM22 | XRCC6 | 0.699068 | 10 | 0 | 10 |
| TOMM22 | ORMDL2 | 0.697771 | 3 | 0 | 3 |
| TOMM22 | DCLRE1B | 0.695523 | 3 | 0 | 3 |
| TOMM22 | MCU | 0.694816 | 4 | 0 | 3 |
| TOMM22 | SPPL2A | 0.693185 | 4 | 0 | 3 |
| TOMM22 | KAT7 | 0.690805 | 3 | 0 | 3 |
| TOMM22 | DUS3L | 0.689122 | 3 | 0 | 3 |
| TOMM22 | MPI | 0.688829 | 3 | 0 | 3 |
For details and further investigation, click here
