| Full name: DNA polymerase iota | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 18q21.2 | ||
| Entrez ID: 11201 | HGNC ID: HGNC:9182 | Ensembl Gene: ENSG00000101751 | OMIM ID: 605252 |
| Drug and gene relationship at DGIdb | |||
Expression of POLI:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLI | 11201 | 219317_at | -0.5428 | 0.4767 | |
| GSE20347 | POLI | 11201 | 219317_at | 0.2480 | 0.1086 | |
| GSE23400 | POLI | 11201 | 219317_at | 0.0623 | 0.1867 | |
| GSE26886 | POLI | 11201 | 238992_at | -0.8883 | 0.0028 | |
| GSE29001 | POLI | 11201 | 219317_at | -0.0530 | 0.9360 | |
| GSE38129 | POLI | 11201 | 219317_at | 0.0916 | 0.5567 | |
| GSE45670 | POLI | 11201 | 219317_at | -0.5278 | 0.0140 | |
| GSE53622 | POLI | 11201 | 82177 | -0.3659 | 0.0002 | |
| GSE53624 | POLI | 11201 | 82177 | -0.1945 | 0.0316 | |
| GSE63941 | POLI | 11201 | 219317_at | -1.7737 | 0.0129 | |
| GSE77861 | POLI | 11201 | 219317_at | 0.1655 | 0.6433 | |
| GSE97050 | POLI | 11201 | A_23_P306890 | -0.5834 | 0.1239 | |
| SRP007169 | POLI | 11201 | RNAseq | -0.7279 | 0.1817 | |
| SRP008496 | POLI | 11201 | RNAseq | 0.6655 | 0.2034 | |
| SRP064894 | POLI | 11201 | RNAseq | -0.0167 | 0.9388 | |
| SRP133303 | POLI | 11201 | RNAseq | -0.3210 | 0.1077 | |
| SRP159526 | POLI | 11201 | RNAseq | -0.2892 | 0.3518 | |
| SRP193095 | POLI | 11201 | RNAseq | -0.2564 | 0.0802 | |
| SRP219564 | POLI | 11201 | RNAseq | -0.2658 | 0.5274 | |
| TCGA | POLI | 11201 | RNAseq | -0.3004 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by POLI expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POLI:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLI | 11201 | 1 | 9 | 20 | |
| GSE20123 | POLI | 11201 | 1 | 9 | 20 | |
| GSE43470 | POLI | 11201 | 0 | 5 | 38 | |
| GSE46452 | POLI | 11201 | 1 | 26 | 32 | |
| GSE47630 | POLI | 11201 | 5 | 20 | 15 | |
| GSE54993 | POLI | 11201 | 10 | 0 | 60 | |
| GSE54994 | POLI | 11201 | 2 | 16 | 35 | |
| GSE60625 | POLI | 11201 | 0 | 4 | 7 | |
| GSE74703 | POLI | 11201 | 0 | 5 | 31 | |
| GSE74704 | POLI | 11201 | 1 | 6 | 13 | |
| TCGA | POLI | 11201 | 10 | 43 | 43 |
Total number of gains: 31; Total number of losses: 143; Total Number of normals: 314.
Somatic mutations of POLI:
Generating mutation plots.
Highly correlated genes for POLI:
Showing top 20/526 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLI | RSRC2 | 0.765284 | 3 | 0 | 3 |
| POLI | UBE2E1 | 0.758629 | 3 | 0 | 3 |
| POLI | FPGT | 0.755081 | 3 | 0 | 3 |
| POLI | PTPRA | 0.750574 | 3 | 0 | 3 |
| POLI | SCAI | 0.750058 | 3 | 0 | 3 |
| POLI | IMPA1 | 0.750017 | 3 | 0 | 3 |
| POLI | TRERF1 | 0.745011 | 3 | 0 | 3 |
| POLI | USP38 | 0.743735 | 3 | 0 | 3 |
| POLI | PARP8 | 0.740767 | 3 | 0 | 3 |
| POLI | ASCC3 | 0.735441 | 3 | 0 | 3 |
| POLI | RWDD4 | 0.733569 | 4 | 0 | 3 |
| POLI | SOS1 | 0.733207 | 3 | 0 | 3 |
| POLI | TYW3 | 0.732633 | 4 | 0 | 4 |
| POLI | CD59 | 0.732248 | 3 | 0 | 3 |
| POLI | TBC1D20 | 0.726201 | 4 | 0 | 3 |
| POLI | CRLS1 | 0.719367 | 3 | 0 | 3 |
| POLI | FBXL3 | 0.716453 | 3 | 0 | 3 |
| POLI | IRAK2 | 0.714252 | 3 | 0 | 3 |
| POLI | ACSL1 | 0.712625 | 3 | 0 | 3 |
| POLI | SOX5 | 0.707039 | 3 | 0 | 3 |
For details and further investigation, click here
