| Full name: DENN domain containing 4C | Alias Symbol: FLJ20686|bA513M16.3|RAB10GEF | ||
| Type: protein-coding gene | Cytoband: 9p22.1 | ||
| Entrez ID: 55667 | HGNC ID: HGNC:26079 | Ensembl Gene: ENSG00000137145 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of DENND4C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DENND4C | 55667 | 226867_at | -0.9384 | 0.0147 | |
| GSE20347 | DENND4C | 55667 | 205684_s_at | -1.2652 | 0.0000 | |
| GSE23400 | DENND4C | 55667 | 205684_s_at | -0.3746 | 0.0000 | |
| GSE26886 | DENND4C | 55667 | 226867_at | -0.6573 | 0.0159 | |
| GSE29001 | DENND4C | 55667 | 205684_s_at | -0.7842 | 0.0278 | |
| GSE38129 | DENND4C | 55667 | 205684_s_at | -1.1621 | 0.0000 | |
| GSE45670 | DENND4C | 55667 | 226867_at | -0.5608 | 0.0151 | |
| GSE53622 | DENND4C | 55667 | 46577 | -0.7209 | 0.0000 | |
| GSE53624 | DENND4C | 55667 | 46577 | -0.7195 | 0.0000 | |
| GSE63941 | DENND4C | 55667 | 226867_at | -0.6505 | 0.3337 | |
| GSE77861 | DENND4C | 55667 | 226867_at | -0.9101 | 0.0072 | |
| GSE97050 | DENND4C | 55667 | A_33_P3293668 | -0.9957 | 0.0555 | |
| SRP007169 | DENND4C | 55667 | RNAseq | -1.2778 | 0.0004 | |
| SRP008496 | DENND4C | 55667 | RNAseq | -1.0335 | 0.0000 | |
| SRP064894 | DENND4C | 55667 | RNAseq | -0.5336 | 0.0447 | |
| SRP133303 | DENND4C | 55667 | RNAseq | -0.5087 | 0.0006 | |
| SRP159526 | DENND4C | 55667 | RNAseq | -1.3807 | 0.0001 | |
| SRP193095 | DENND4C | 55667 | RNAseq | -0.8622 | 0.0000 | |
| SRP219564 | DENND4C | 55667 | RNAseq | -0.8532 | 0.0188 | |
| TCGA | DENND4C | 55667 | RNAseq | -0.2717 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by DENND4C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DENND4C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DENND4C | 55667 | 2 | 16 | 12 | |
| GSE20123 | DENND4C | 55667 | 2 | 16 | 12 | |
| GSE43470 | DENND4C | 55667 | 5 | 11 | 27 | |
| GSE46452 | DENND4C | 55667 | 2 | 23 | 34 | |
| GSE47630 | DENND4C | 55667 | 3 | 27 | 10 | |
| GSE54993 | DENND4C | 55667 | 6 | 2 | 62 | |
| GSE54994 | DENND4C | 55667 | 8 | 17 | 28 | |
| GSE60625 | DENND4C | 55667 | 0 | 0 | 11 | |
| GSE74703 | DENND4C | 55667 | 5 | 8 | 23 | |
| GSE74704 | DENND4C | 55667 | 0 | 13 | 7 | |
| TCGA | DENND4C | 55667 | 12 | 51 | 33 |
Total number of gains: 45; Total number of losses: 184; Total Number of normals: 259.
Somatic mutations of DENND4C:
Generating mutation plots.
Highly correlated genes for DENND4C:
Showing top 20/1504 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DENND4C | KDM5D | 0.79797 | 3 | 0 | 3 |
| DENND4C | ATG2B | 0.777711 | 3 | 0 | 3 |
| DENND4C | USP33 | 0.776025 | 3 | 0 | 3 |
| DENND4C | NDUFV3 | 0.766709 | 3 | 0 | 3 |
| DENND4C | ELL3 | 0.764388 | 3 | 0 | 3 |
| DENND4C | HDHD2 | 0.763266 | 5 | 0 | 5 |
| DENND4C | MIER3 | 0.756091 | 3 | 0 | 3 |
| DENND4C | EIF4E3 | 0.749755 | 7 | 0 | 7 |
| DENND4C | SPRYD4 | 0.747799 | 3 | 0 | 3 |
| DENND4C | SRSF8 | 0.743663 | 4 | 0 | 4 |
| DENND4C | FBXO8 | 0.733367 | 7 | 0 | 7 |
| DENND4C | AK3 | 0.73044 | 9 | 0 | 8 |
| DENND4C | KAT2B | 0.729701 | 11 | 0 | 11 |
| DENND4C | ACSL1 | 0.728478 | 4 | 0 | 4 |
| DENND4C | ZNF554 | 0.724958 | 3 | 0 | 3 |
| DENND4C | AFF1 | 0.724458 | 6 | 0 | 6 |
| DENND4C | LRRK2 | 0.724162 | 7 | 0 | 6 |
| DENND4C | ZNF92 | 0.723788 | 3 | 0 | 3 |
| DENND4C | ZNF844 | 0.721108 | 6 | 0 | 6 |
| DENND4C | SUCLG2 | 0.718345 | 11 | 0 | 11 |
For details and further investigation, click here
