| Full name: WNK lysine deficient protein kinase 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 65266 | HGNC ID: HGNC:14544 | Ensembl Gene: ENSG00000126562 | OMIM ID: 601844 |
| Drug and gene relationship at DGIdb | |||
Expression of WNK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WNK4 | 65266 | 229158_at | -1.3504 | 0.1168 | |
| GSE26886 | WNK4 | 65266 | 229158_at | -3.0803 | 0.0000 | |
| GSE45670 | WNK4 | 65266 | 229158_at | -1.4802 | 0.0003 | |
| GSE53622 | WNK4 | 65266 | 123405 | -1.4838 | 0.0000 | |
| GSE53624 | WNK4 | 65266 | 123405 | -0.5115 | 0.0000 | |
| GSE63941 | WNK4 | 65266 | 229158_at | -0.7240 | 0.1615 | |
| GSE77861 | WNK4 | 65266 | 229158_at | -1.3836 | 0.0113 | |
| GSE97050 | WNK4 | 65266 | A_24_P327181 | -0.8173 | 0.3573 | |
| SRP007169 | WNK4 | 65266 | RNAseq | -5.8438 | 0.0000 | |
| SRP008496 | WNK4 | 65266 | RNAseq | -5.3419 | 0.0000 | |
| SRP064894 | WNK4 | 65266 | RNAseq | -3.1342 | 0.0000 | |
| SRP133303 | WNK4 | 65266 | RNAseq | -3.7471 | 0.0000 | |
| SRP159526 | WNK4 | 65266 | RNAseq | -3.2640 | 0.0001 | |
| SRP193095 | WNK4 | 65266 | RNAseq | -2.2064 | 0.0000 | |
| SRP219564 | WNK4 | 65266 | RNAseq | -3.6957 | 0.0000 | |
| TCGA | WNK4 | 65266 | RNAseq | -1.8463 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by WNK4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WNK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WNK4 | 65266 | 6 | 2 | 22 | |
| GSE20123 | WNK4 | 65266 | 6 | 2 | 22 | |
| GSE43470 | WNK4 | 65266 | 1 | 2 | 40 | |
| GSE46452 | WNK4 | 65266 | 34 | 0 | 25 | |
| GSE47630 | WNK4 | 65266 | 8 | 1 | 31 | |
| GSE54993 | WNK4 | 65266 | 3 | 4 | 63 | |
| GSE54994 | WNK4 | 65266 | 8 | 5 | 40 | |
| GSE60625 | WNK4 | 65266 | 4 | 0 | 7 | |
| GSE74703 | WNK4 | 65266 | 1 | 1 | 34 | |
| GSE74704 | WNK4 | 65266 | 4 | 1 | 15 | |
| TCGA | WNK4 | 65266 | 22 | 7 | 67 |
Total number of gains: 97; Total number of losses: 25; Total Number of normals: 366.
Somatic mutations of WNK4:
Generating mutation plots.
Highly correlated genes for WNK4:
Showing top 20/780 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WNK4 | PAQR8 | 0.820621 | 5 | 0 | 5 |
| WNK4 | SNORA68 | 0.792147 | 4 | 0 | 4 |
| WNK4 | PMM1 | 0.786508 | 7 | 0 | 7 |
| WNK4 | SAMD5 | 0.782977 | 5 | 0 | 5 |
| WNK4 | MFSD2B | 0.775845 | 3 | 0 | 3 |
| WNK4 | FNDC4 | 0.774373 | 7 | 0 | 7 |
| WNK4 | IL12A | 0.771997 | 6 | 0 | 6 |
| WNK4 | CTTNBP2 | 0.770978 | 7 | 0 | 7 |
| WNK4 | SFTA2 | 0.770542 | 4 | 0 | 4 |
| WNK4 | EPHX2 | 0.762989 | 6 | 0 | 6 |
| WNK4 | MGST2 | 0.754965 | 5 | 0 | 5 |
| WNK4 | GPD1L | 0.750415 | 5 | 0 | 5 |
| WNK4 | GMDS | 0.747613 | 4 | 0 | 4 |
| WNK4 | ACSM1 | 0.747477 | 3 | 0 | 3 |
| WNK4 | RAB5B | 0.747426 | 5 | 0 | 5 |
| WNK4 | PPDPF | 0.744789 | 4 | 0 | 4 |
| WNK4 | ZNF662 | 0.742577 | 5 | 0 | 5 |
| WNK4 | CGNL1 | 0.740639 | 5 | 0 | 5 |
| WNK4 | ALDH9A1 | 0.739288 | 6 | 0 | 6 |
| WNK4 | SUMF1 | 0.737054 | 4 | 0 | 4 |
For details and further investigation, click here
