| Full name: DM1 protein kinase | Alias Symbol: DMK|DM1PK|MDPK|MT-PK | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 1760 | HGNC ID: HGNC:2933 | Ensembl Gene: ENSG00000104936 | OMIM ID: 605377 |
| Drug and gene relationship at DGIdb | |||
Expression of DMPK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DMPK | 1760 | 37996_s_at | -0.8642 | 0.3742 | |
| GSE20347 | DMPK | 1760 | 37996_s_at | -0.6786 | 0.0008 | |
| GSE23400 | DMPK | 1760 | 217066_s_at | -0.3213 | 0.0020 | |
| GSE26886 | DMPK | 1760 | 217066_s_at | -0.0821 | 0.5548 | |
| GSE29001 | DMPK | 1760 | 37996_s_at | -0.4143 | 0.0698 | |
| GSE38129 | DMPK | 1760 | 37996_s_at | -1.0434 | 0.0003 | |
| GSE45670 | DMPK | 1760 | 37996_s_at | -0.4663 | 0.0000 | |
| GSE53622 | DMPK | 1760 | 11526 | -0.1082 | 0.0732 | |
| GSE53624 | DMPK | 1760 | 11526 | 0.1554 | 0.0102 | |
| GSE63941 | DMPK | 1760 | 37996_s_at | 0.1776 | 0.5938 | |
| GSE77861 | DMPK | 1760 | 217066_s_at | -0.0078 | 0.9750 | |
| GSE97050 | DMPK | 1760 | A_23_P50535 | -0.9534 | 0.2423 | |
| SRP007169 | DMPK | 1760 | RNAseq | -2.0732 | 0.0000 | |
| SRP008496 | DMPK | 1760 | RNAseq | -1.4719 | 0.0003 | |
| SRP064894 | DMPK | 1760 | RNAseq | 0.1358 | 0.6615 | |
| SRP133303 | DMPK | 1760 | RNAseq | -1.0408 | 0.0003 | |
| SRP159526 | DMPK | 1760 | RNAseq | -0.4589 | 0.3827 | |
| SRP193095 | DMPK | 1760 | RNAseq | 0.1459 | 0.3959 | |
| SRP219564 | DMPK | 1760 | RNAseq | -0.7623 | 0.4098 | |
| TCGA | DMPK | 1760 | RNAseq | -0.3462 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by DMPK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DMPK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DMPK | 1760 | 4 | 5 | 21 | |
| GSE20123 | DMPK | 1760 | 4 | 4 | 22 | |
| GSE43470 | DMPK | 1760 | 3 | 11 | 29 | |
| GSE46452 | DMPK | 1760 | 45 | 1 | 13 | |
| GSE47630 | DMPK | 1760 | 8 | 7 | 25 | |
| GSE54993 | DMPK | 1760 | 17 | 4 | 49 | |
| GSE54994 | DMPK | 1760 | 5 | 13 | 35 | |
| GSE60625 | DMPK | 1760 | 9 | 0 | 2 | |
| GSE74703 | DMPK | 1760 | 3 | 7 | 26 | |
| GSE74704 | DMPK | 1760 | 4 | 2 | 14 | |
| TCGA | DMPK | 1760 | 16 | 15 | 65 |
Total number of gains: 118; Total number of losses: 69; Total Number of normals: 301.
Somatic mutations of DMPK:
Generating mutation plots.
Highly correlated genes for DMPK:
Showing top 20/915 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DMPK | ATP10A | 0.830686 | 3 | 0 | 3 |
| DMPK | MAMDC2 | 0.82216 | 3 | 0 | 3 |
| DMPK | DDX42 | 0.799398 | 3 | 0 | 3 |
| DMPK | SLIT2 | 0.790255 | 6 | 0 | 6 |
| DMPK | ST6GAL2 | 0.787538 | 3 | 0 | 3 |
| DMPK | GMPR | 0.767566 | 3 | 0 | 3 |
| DMPK | SERTAD1 | 0.764015 | 3 | 0 | 3 |
| DMPK | PI16 | 0.762261 | 4 | 0 | 3 |
| DMPK | ADRB3 | 0.758279 | 3 | 0 | 3 |
| DMPK | SIN3A | 0.755622 | 3 | 0 | 3 |
| DMPK | PRUNE2 | 0.750781 | 7 | 0 | 6 |
| DMPK | SMTN | 0.749508 | 6 | 0 | 5 |
| DMPK | MCAM | 0.74875 | 4 | 0 | 4 |
| DMPK | CHRDL1 | 0.747289 | 7 | 0 | 6 |
| DMPK | TMOD1 | 0.746985 | 6 | 0 | 5 |
| DMPK | CNN1 | 0.746319 | 7 | 0 | 6 |
| DMPK | ARMC9 | 0.744762 | 3 | 0 | 3 |
| DMPK | PPP1R12B | 0.743353 | 7 | 0 | 6 |
| DMPK | VIT | 0.741465 | 3 | 0 | 3 |
| DMPK | ZNF609 | 0.737704 | 3 | 0 | 3 |
For details and further investigation, click here
