ACTR6

 

Full name: actin related protein 6 Alias Symbol: ARP6|FLJ13433
Type: protein-coding gene Cytoband: 12q23.1
Entrez ID: 64431 HGNC ID: HGNC:24025 Ensembl Gene: ENSG00000075089 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ACTR6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ACTR6 64431 218395_at 0.2170 0.5836
GSE20347 ACTR6 64431 218395_at 0.2645 0.1126
GSE23400 ACTR6 64431 218395_at 0.4295 0.0000
GSE26886 ACTR6 64431 218395_at 0.2946 0.2961
GSE29001 ACTR6 64431 218395_at 0.4295 0.3890
GSE38129 ACTR6 64431 218395_at 0.3183 0.0146
GSE45670 ACTR6 64431 218395_at 0.1514 0.2305
GSE53622 ACTR6 64431 102102 0.1959 0.0136
GSE53624 ACTR6 64431 102102 0.3290 0.0000
GSE63941 ACTR6 64431 218395_at 0.2144 0.6437
GSE77861 ACTR6 64431 218395_at 0.4239 0.1922
GSE97050 ACTR6 64431 A_23_P162596 0.0718 0.8236
SRP007169 ACTR6 64431 RNAseq 0.0801 0.8248
SRP008496 ACTR6 64431 RNAseq 0.1166 0.5743
SRP064894 ACTR6 64431 RNAseq -0.1168 0.4348
SRP133303 ACTR6 64431 RNAseq 0.4364 0.1126
SRP159526 ACTR6 64431 RNAseq 0.4719 0.1751
SRP193095 ACTR6 64431 RNAseq -0.0612 0.6544
SRP219564 ACTR6 64431 RNAseq -0.6056 0.0281
TCGA ACTR6 64431 RNAseq 0.1909 0.0026

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ACTR6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ACTR6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ACTR6 64431 2 2 26
GSE20123 ACTR6 64431 2 2 26
GSE43470 ACTR6 64431 2 0 41
GSE46452 ACTR6 64431 9 1 49
GSE47630 ACTR6 64431 9 1 30
GSE54993 ACTR6 64431 0 5 65
GSE54994 ACTR6 64431 4 2 47
GSE60625 ACTR6 64431 0 0 11
GSE74703 ACTR6 64431 2 0 34
GSE74704 ACTR6 64431 1 2 17
TCGA ACTR6 64431 18 11 67

Total number of gains: 49; Total number of losses: 26; Total Number of normals: 413.  

 

Somatic mutations of ACTR6:

 

Generating mutation plots.

 

Highly correlated genes for ACTR6:

 

Showing top 20/972 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ACTR6ZNF7640.759484303
ACTR6ZSCAN250.754554303
ACTR6PTPN130.736846303
ACTR6HPS30.733965404
ACTR6SYT170.721374303
ACTR6ATG4C0.714985303
ACTR6AGTPBP10.709216303
ACTR6GK50.707101303
ACTR6FARS20.705007303
ACTR6MGAT4B0.703747303
ACTR6RPP380.694026504
ACTR6RCHY10.692615303
ACTR6SLC25A400.690392403
ACTR6SHPRH0.685393404
ACTR6ING20.681611404
ACTR6LUC7L20.681598404
ACTR6ANKEF10.678255303
ACTR6HINT30.677871303
ACTR6RNF40.67497303
ACTR6GPANK10.673802403

For details and further investigation, click here