| Full name: histidine triad nucleotide binding protein 3 | Alias Symbol: FLJ33126|HINT4 | ||
| Type: protein-coding gene | Cytoband: 6q22.32 | ||
| Entrez ID: 135114 | HGNC ID: HGNC:18468 | Ensembl Gene: ENSG00000111911 | OMIM ID: 609998 |
| Drug and gene relationship at DGIdb | |||
Expression of HINT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HINT3 | 135114 | 226537_at | -0.0133 | 0.9903 | |
| GSE26886 | HINT3 | 135114 | 228697_at | -0.2857 | 0.4501 | |
| GSE45670 | HINT3 | 135114 | 228697_at | -0.6163 | 0.0004 | |
| GSE53622 | HINT3 | 135114 | 17847 | -1.0896 | 0.0000 | |
| GSE53624 | HINT3 | 135114 | 17847 | -0.6309 | 0.0000 | |
| GSE63941 | HINT3 | 135114 | 228697_at | -0.2361 | 0.7638 | |
| GSE77861 | HINT3 | 135114 | 228697_at | -0.2415 | 0.2499 | |
| GSE97050 | HINT3 | 135114 | A_33_P3299872 | -1.0489 | 0.1095 | |
| SRP007169 | HINT3 | 135114 | RNAseq | -1.8508 | 0.0120 | |
| SRP008496 | HINT3 | 135114 | RNAseq | -1.3813 | 0.0383 | |
| SRP064894 | HINT3 | 135114 | RNAseq | -0.7954 | 0.0000 | |
| SRP133303 | HINT3 | 135114 | RNAseq | -0.1898 | 0.1084 | |
| SRP159526 | HINT3 | 135114 | RNAseq | -0.4162 | 0.1477 | |
| SRP193095 | HINT3 | 135114 | RNAseq | -0.6501 | 0.0000 | |
| SRP219564 | HINT3 | 135114 | RNAseq | -1.0628 | 0.0114 | |
| TCGA | HINT3 | 135114 | RNAseq | -0.3184 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by HINT3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HINT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HINT3 | 135114 | 1 | 4 | 25 | |
| GSE20123 | HINT3 | 135114 | 2 | 3 | 25 | |
| GSE43470 | HINT3 | 135114 | 5 | 0 | 38 | |
| GSE46452 | HINT3 | 135114 | 2 | 11 | 46 | |
| GSE47630 | HINT3 | 135114 | 9 | 4 | 27 | |
| GSE54993 | HINT3 | 135114 | 4 | 2 | 64 | |
| GSE54994 | HINT3 | 135114 | 8 | 8 | 37 | |
| GSE60625 | HINT3 | 135114 | 0 | 1 | 10 | |
| GSE74703 | HINT3 | 135114 | 4 | 0 | 32 | |
| GSE74704 | HINT3 | 135114 | 0 | 1 | 19 | |
| TCGA | HINT3 | 135114 | 11 | 19 | 66 |
Total number of gains: 46; Total number of losses: 53; Total Number of normals: 389.
Somatic mutations of HINT3:
Generating mutation plots.
Highly correlated genes for HINT3:
Showing top 20/729 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HINT3 | ARHGAP31 | 0.767426 | 3 | 0 | 3 |
| HINT3 | TRAPPC3 | 0.764332 | 3 | 0 | 3 |
| HINT3 | HLF | 0.756688 | 4 | 0 | 4 |
| HINT3 | EIF4E3 | 0.750283 | 4 | 0 | 4 |
| HINT3 | PDCD4 | 0.742869 | 3 | 0 | 3 |
| HINT3 | ATP6V0E1 | 0.740299 | 3 | 0 | 3 |
| HINT3 | ABHD14B | 0.738375 | 3 | 0 | 3 |
| HINT3 | UBE4B | 0.724744 | 3 | 0 | 3 |
| HINT3 | MED4 | 0.723624 | 3 | 0 | 3 |
| HINT3 | MKKS | 0.723287 | 3 | 0 | 3 |
| HINT3 | NDUFB8 | 0.721719 | 3 | 0 | 3 |
| HINT3 | CRBN | 0.719572 | 4 | 0 | 4 |
| HINT3 | SKP1 | 0.717508 | 4 | 0 | 4 |
| HINT3 | TCHP | 0.71392 | 3 | 0 | 3 |
| HINT3 | ZACN | 0.713814 | 4 | 0 | 3 |
| HINT3 | GPD1L | 0.712273 | 5 | 0 | 4 |
| HINT3 | MOB4 | 0.709133 | 4 | 0 | 4 |
| HINT3 | ANKHD1 | 0.707997 | 3 | 0 | 3 |
| HINT3 | HDHD2 | 0.707184 | 4 | 0 | 4 |
| HINT3 | BTAF1 | 0.70664 | 4 | 0 | 4 |
For details and further investigation, click here
