| Full name: ADAM metallopeptidase domain 20 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q24.2 | ||
| Entrez ID: 8748 | HGNC ID: HGNC:199 | Ensembl Gene: ENSG00000134007 | OMIM ID: 603712 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAM20:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAM20 | 8748 | 207422_at | 0.0590 | 0.8146 | |
| GSE20347 | ADAM20 | 8748 | 207422_at | -0.0032 | 0.9686 | |
| GSE23400 | ADAM20 | 8748 | 207423_s_at | -0.1238 | 0.0002 | |
| GSE26886 | ADAM20 | 8748 | 207422_at | 0.0307 | 0.7632 | |
| GSE29001 | ADAM20 | 8748 | 207423_s_at | -0.0829 | 0.6318 | |
| GSE38129 | ADAM20 | 8748 | 207422_at | -0.0881 | 0.2352 | |
| GSE45670 | ADAM20 | 8748 | 207422_at | -0.0045 | 0.9616 | |
| GSE53622 | ADAM20 | 8748 | 61198 | 0.3045 | 0.0087 | |
| GSE53624 | ADAM20 | 8748 | 61198 | 0.0716 | 0.4401 | |
| GSE63941 | ADAM20 | 8748 | 207422_at | 0.0907 | 0.4890 | |
| GSE77861 | ADAM20 | 8748 | 207423_s_at | -0.0479 | 0.6119 | |
| GSE97050 | ADAM20 | 8748 | A_23_P48698 | 0.0231 | 0.9306 | |
| SRP133303 | ADAM20 | 8748 | RNAseq | 0.3165 | 0.2021 | |
| TCGA | ADAM20 | 8748 | RNAseq | 1.1658 | 0.0059 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ADAM20 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAM20:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAM20 | 8748 | 8 | 3 | 19 | |
| GSE20123 | ADAM20 | 8748 | 8 | 3 | 19 | |
| GSE43470 | ADAM20 | 8748 | 8 | 3 | 32 | |
| GSE46452 | ADAM20 | 8748 | 16 | 3 | 40 | |
| GSE47630 | ADAM20 | 8748 | 11 | 9 | 20 | |
| GSE54993 | ADAM20 | 8748 | 3 | 9 | 58 | |
| GSE54994 | ADAM20 | 8748 | 18 | 5 | 30 | |
| GSE60625 | ADAM20 | 8748 | 0 | 2 | 9 | |
| GSE74703 | ADAM20 | 8748 | 7 | 3 | 26 | |
| GSE74704 | ADAM20 | 8748 | 3 | 3 | 14 | |
| TCGA | ADAM20 | 8748 | 32 | 16 | 48 |
Total number of gains: 114; Total number of losses: 59; Total Number of normals: 315.
Somatic mutations of ADAM20:
Generating mutation plots.
Highly correlated genes for ADAM20:
Showing top 20/430 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAM20 | TNP1 | 0.700179 | 3 | 0 | 3 |
| ADAM20 | ZNF221 | 0.68126 | 3 | 0 | 3 |
| ADAM20 | POU4F3 | 0.677044 | 3 | 0 | 3 |
| ADAM20 | OPTC | 0.666758 | 3 | 0 | 3 |
| ADAM20 | FERD3L | 0.662247 | 3 | 0 | 3 |
| ADAM20 | GRIN1 | 0.649116 | 4 | 0 | 3 |
| ADAM20 | CD1B | 0.648573 | 5 | 0 | 4 |
| ADAM20 | WNT1 | 0.645827 | 4 | 0 | 3 |
| ADAM20 | DAO | 0.638712 | 6 | 0 | 5 |
| ADAM20 | KIR3DL3 | 0.634782 | 5 | 0 | 4 |
| ADAM20 | C3orf36 | 0.630568 | 6 | 0 | 5 |
| ADAM20 | SLC6A13 | 0.629821 | 5 | 0 | 4 |
| ADAM20 | CSMD2 | 0.629686 | 4 | 0 | 3 |
| ADAM20 | FTCD | 0.628177 | 4 | 0 | 3 |
| ADAM20 | FAM189A1 | 0.628147 | 5 | 0 | 4 |
| ADAM20 | PHF7 | 0.626565 | 5 | 0 | 3 |
| ADAM20 | PPP2R2B | 0.625 | 5 | 0 | 4 |
| ADAM20 | CCDC81 | 0.623885 | 4 | 0 | 3 |
| ADAM20 | IL1RAPL2 | 0.621691 | 6 | 0 | 5 |
| ADAM20 | LRTM1 | 0.620511 | 6 | 0 | 5 |
For details and further investigation, click here
