| Full name: claudin 18 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q22.3 | ||
| Entrez ID: 51208 | HGNC ID: HGNC:2039 | Ensembl Gene: ENSG00000066405 | OMIM ID: 609210 |
| Drug and gene relationship at DGIdb | |||
CLDN18 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of CLDN18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLDN18 | 51208 | 214135_at | 0.0701 | 0.8314 | |
| GSE20347 | CLDN18 | 51208 | 214135_at | -0.0126 | 0.9440 | |
| GSE23400 | CLDN18 | 51208 | 214135_at | -0.2438 | 0.0334 | |
| GSE26886 | CLDN18 | 51208 | 214135_at | 0.2781 | 0.1635 | |
| GSE29001 | CLDN18 | 51208 | 221132_at | -0.2543 | 0.0582 | |
| GSE38129 | CLDN18 | 51208 | 214135_at | -0.6715 | 0.1135 | |
| GSE45670 | CLDN18 | 51208 | 221133_s_at | 0.1647 | 0.0650 | |
| GSE53622 | CLDN18 | 51208 | 124145 | 0.5484 | 0.1215 | |
| GSE53624 | CLDN18 | 51208 | 124145 | 0.2286 | 0.4907 | |
| GSE63941 | CLDN18 | 51208 | 214135_at | 0.1541 | 0.2869 | |
| GSE77861 | CLDN18 | 51208 | 214135_at | 0.0373 | 0.7980 | |
| GSE97050 | CLDN18 | 51208 | A_33_P3240752 | -0.0205 | 0.9609 | |
| SRP064894 | CLDN18 | 51208 | RNAseq | 0.6221 | 0.0711 | |
| SRP133303 | CLDN18 | 51208 | RNAseq | 0.2662 | 0.4720 | |
| SRP159526 | CLDN18 | 51208 | RNAseq | 1.9954 | 0.0019 | |
| SRP193095 | CLDN18 | 51208 | RNAseq | -3.3260 | 0.0000 | |
| SRP219564 | CLDN18 | 51208 | RNAseq | 0.8006 | 0.1088 | |
| TCGA | CLDN18 | 51208 | RNAseq | -3.1301 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by CLDN18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLDN18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLDN18 | 51208 | 16 | 0 | 14 | |
| GSE20123 | CLDN18 | 51208 | 16 | 0 | 14 | |
| GSE43470 | CLDN18 | 51208 | 21 | 0 | 22 | |
| GSE46452 | CLDN18 | 51208 | 15 | 4 | 40 | |
| GSE47630 | CLDN18 | 51208 | 18 | 3 | 19 | |
| GSE54993 | CLDN18 | 51208 | 2 | 8 | 60 | |
| GSE54994 | CLDN18 | 51208 | 31 | 2 | 20 | |
| GSE60625 | CLDN18 | 51208 | 0 | 6 | 5 | |
| GSE74703 | CLDN18 | 51208 | 18 | 0 | 18 | |
| GSE74704 | CLDN18 | 51208 | 11 | 0 | 9 | |
| TCGA | CLDN18 | 51208 | 61 | 4 | 31 |
Total number of gains: 209; Total number of losses: 27; Total Number of normals: 252.
Somatic mutations of CLDN18:
Generating mutation plots.
Highly correlated genes for CLDN18:
Showing top 20/207 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLDN18 | LIPF | 0.79343 | 8 | 0 | 7 |
| CLDN18 | GKN2 | 0.776892 | 3 | 0 | 3 |
| CLDN18 | RAPGEF1 | 0.77381 | 3 | 0 | 3 |
| CLDN18 | GKN1 | 0.764026 | 7 | 0 | 7 |
| CLDN18 | ADAM22 | 0.757002 | 3 | 0 | 3 |
| CLDN18 | TMSB4Y | 0.755714 | 3 | 0 | 3 |
| CLDN18 | NOL12 | 0.755114 | 3 | 0 | 3 |
| CLDN18 | ATP4B | 0.748749 | 6 | 0 | 6 |
| CLDN18 | MAPRE3 | 0.745851 | 3 | 0 | 3 |
| CLDN18 | GDF5 | 0.742128 | 3 | 0 | 3 |
| CLDN18 | ATP4A | 0.741712 | 6 | 0 | 6 |
| CLDN18 | NEU3 | 0.731373 | 3 | 0 | 3 |
| CLDN18 | KCNE2 | 0.725544 | 5 | 0 | 5 |
| CLDN18 | NLGN4Y | 0.722536 | 3 | 0 | 3 |
| CLDN18 | CSF3R | 0.7157 | 3 | 0 | 3 |
| CLDN18 | EPN1 | 0.71293 | 3 | 0 | 3 |
| CLDN18 | CACNA2D4 | 0.712471 | 3 | 0 | 3 |
| CLDN18 | FUT9 | 0.707501 | 5 | 0 | 4 |
| CLDN18 | REG1A | 0.707229 | 5 | 0 | 5 |
| CLDN18 | HTR1D | 0.706172 | 3 | 0 | 3 |
For details and further investigation, click here
