| Full name: matrix metallopeptidase 9 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 20q13.12 | ||
| Entrez ID: 4318 | HGNC ID: HGNC:7176 | Ensembl Gene: ENSG00000100985 | OMIM ID: 120361 |
| Drug and gene relationship at DGIdb | |||
MMP9 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04670 | Leukocyte transendothelial migration | |
| hsa04915 | Estrogen signaling pathway | |
| hsa05161 | Hepatitis B | |
| hsa05200 | Pathways in cancer | |
| hsa05205 | Proteoglycans in cancer |
Expression of MMP9:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMP9 | 4318 | 203936_s_at | 2.4326 | 0.0808 | |
| GSE20347 | MMP9 | 4318 | 203936_s_at | 1.5135 | 0.0000 | |
| GSE23400 | MMP9 | 4318 | 203936_s_at | 1.5642 | 0.0000 | |
| GSE26886 | MMP9 | 4318 | 203936_s_at | 2.3827 | 0.0092 | |
| GSE29001 | MMP9 | 4318 | 203936_s_at | 2.2533 | 0.0000 | |
| GSE38129 | MMP9 | 4318 | 203936_s_at | 1.9439 | 0.0000 | |
| GSE45670 | MMP9 | 4318 | 203936_s_at | 2.0230 | 0.0003 | |
| GSE53622 | MMP9 | 4318 | 11788 | 0.9896 | 0.0000 | |
| GSE53624 | MMP9 | 4318 | 11788 | 1.0131 | 0.0000 | |
| GSE63941 | MMP9 | 4318 | 203936_s_at | 0.6703 | 0.0082 | |
| GSE77861 | MMP9 | 4318 | 203936_s_at | 0.6697 | 0.0443 | |
| GSE97050 | MMP9 | 4318 | A_23_P40174 | 0.4066 | 0.2025 | |
| SRP008496 | MMP9 | 4318 | RNAseq | 6.6112 | 0.0000 | |
| SRP064894 | MMP9 | 4318 | RNAseq | 5.7118 | 0.0000 | |
| SRP133303 | MMP9 | 4318 | RNAseq | 2.9805 | 0.0000 | |
| SRP159526 | MMP9 | 4318 | RNAseq | 1.3653 | 0.1250 | |
| SRP193095 | MMP9 | 4318 | RNAseq | 3.9674 | 0.0000 | |
| SRP219564 | MMP9 | 4318 | RNAseq | 3.7417 | 0.0000 | |
| TCGA | MMP9 | 4318 | RNAseq | 1.4397 | 0.0000 |
Upregulated datasets: 13; Downregulated datasets: 0.
Survival by MMP9 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMP9:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMP9 | 4318 | 14 | 1 | 15 | |
| GSE20123 | MMP9 | 4318 | 14 | 1 | 15 | |
| GSE43470 | MMP9 | 4318 | 12 | 1 | 30 | |
| GSE46452 | MMP9 | 4318 | 29 | 0 | 30 | |
| GSE47630 | MMP9 | 4318 | 24 | 1 | 15 | |
| GSE54993 | MMP9 | 4318 | 0 | 17 | 53 | |
| GSE54994 | MMP9 | 4318 | 25 | 0 | 28 | |
| GSE60625 | MMP9 | 4318 | 0 | 0 | 11 | |
| GSE74703 | MMP9 | 4318 | 10 | 1 | 25 | |
| GSE74704 | MMP9 | 4318 | 10 | 0 | 10 | |
| TCGA | MMP9 | 4318 | 46 | 3 | 47 |
Total number of gains: 184; Total number of losses: 25; Total Number of normals: 279.
Somatic mutations of MMP9:
Generating mutation plots.
Highly correlated genes for MMP9:
Showing top 20/963 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMP9 | MFAP2 | 0.735419 | 11 | 0 | 11 |
| MMP9 | MMP12 | 0.73362 | 12 | 0 | 11 |
| MMP9 | MMP1 | 0.730344 | 12 | 0 | 11 |
| MMP9 | ADAMTS2 | 0.72905 | 5 | 0 | 5 |
| MMP9 | ARPC1B | 0.718433 | 10 | 0 | 9 |
| MMP9 | TTYH3 | 0.714645 | 7 | 0 | 7 |
| MMP9 | SPP1 | 0.707202 | 11 | 0 | 11 |
| MMP9 | PLAUR | 0.698162 | 10 | 0 | 10 |
| MMP9 | COL5A2 | 0.697983 | 11 | 0 | 11 |
| MMP9 | RNF139-AS1 | 0.68879 | 3 | 0 | 3 |
| MMP9 | PLAU | 0.672615 | 12 | 0 | 10 |
| MMP9 | LRRC15 | 0.671423 | 10 | 0 | 9 |
| MMP9 | RUNX1-IT1 | 0.671252 | 7 | 0 | 6 |
| MMP9 | COL10A1 | 0.671127 | 11 | 0 | 10 |
| MMP9 | SNX10 | 0.66923 | 12 | 0 | 11 |
| MMP9 | LAMC2 | 0.668768 | 13 | 0 | 12 |
| MMP9 | SCO2 | 0.667505 | 4 | 0 | 4 |
| MMP9 | SLC28A3 | 0.666426 | 3 | 0 | 3 |
| MMP9 | COLGALT1 | 0.664915 | 10 | 0 | 10 |
| MMP9 | MYH9 | 0.664322 | 8 | 0 | 8 |
For details and further investigation, click here
