| Full name: F-box and leucine rich repeat protein 8 | Alias Symbol: Fbl8 | ||
| Type: protein-coding gene | Cytoband: 16q22.1 | ||
| Entrez ID: 55336 | HGNC ID: HGNC:17875 | Ensembl Gene: ENSG00000135722 | OMIM ID: 609077 |
| Drug and gene relationship at DGIdb | |||
Expression of FBXL8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXL8 | 55336 | 220080_at | 0.5885 | 0.1381 | |
| GSE20347 | FBXL8 | 55336 | 220080_at | 0.0208 | 0.8401 | |
| GSE23400 | FBXL8 | 55336 | 220080_at | -0.0659 | 0.0718 | |
| GSE26886 | FBXL8 | 55336 | 220080_at | 0.5241 | 0.0019 | |
| GSE29001 | FBXL8 | 55336 | 220080_at | -0.0165 | 0.9063 | |
| GSE38129 | FBXL8 | 55336 | 220080_at | 0.1461 | 0.1153 | |
| GSE45670 | FBXL8 | 55336 | 220080_at | -0.0230 | 0.8515 | |
| GSE53622 | FBXL8 | 55336 | 126770 | -0.4717 | 0.0001 | |
| GSE53624 | FBXL8 | 55336 | 126770 | -0.2116 | 0.0277 | |
| GSE63941 | FBXL8 | 55336 | 220080_at | -0.1307 | 0.5288 | |
| GSE77861 | FBXL8 | 55336 | 220080_at | -0.0870 | 0.5556 | |
| GSE97050 | FBXL8 | 55336 | A_33_P3284586 | -0.0194 | 0.9420 | |
| SRP007169 | FBXL8 | 55336 | RNAseq | -0.9464 | 0.0894 | |
| SRP064894 | FBXL8 | 55336 | RNAseq | 0.3783 | 0.2776 | |
| SRP133303 | FBXL8 | 55336 | RNAseq | -0.1558 | 0.3779 | |
| SRP159526 | FBXL8 | 55336 | RNAseq | -0.1671 | 0.6270 | |
| SRP193095 | FBXL8 | 55336 | RNAseq | 0.5306 | 0.0067 | |
| SRP219564 | FBXL8 | 55336 | RNAseq | 0.0898 | 0.7970 | |
| TCGA | FBXL8 | 55336 | RNAseq | 0.0292 | 0.7513 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FBXL8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBXL8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXL8 | 55336 | 8 | 2 | 20 | |
| GSE20123 | FBXL8 | 55336 | 8 | 2 | 20 | |
| GSE43470 | FBXL8 | 55336 | 1 | 9 | 33 | |
| GSE46452 | FBXL8 | 55336 | 38 | 1 | 20 | |
| GSE47630 | FBXL8 | 55336 | 10 | 8 | 22 | |
| GSE54993 | FBXL8 | 55336 | 2 | 4 | 64 | |
| GSE54994 | FBXL8 | 55336 | 8 | 10 | 35 | |
| GSE60625 | FBXL8 | 55336 | 4 | 0 | 7 | |
| GSE74703 | FBXL8 | 55336 | 1 | 6 | 29 | |
| GSE74704 | FBXL8 | 55336 | 5 | 1 | 14 | |
| TCGA | FBXL8 | 55336 | 29 | 12 | 55 |
Total number of gains: 114; Total number of losses: 55; Total Number of normals: 319.
Somatic mutations of FBXL8:
Generating mutation plots.
Highly correlated genes for FBXL8:
Showing top 20/141 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXL8 | TMEM102 | 0.76509 | 3 | 0 | 3 |
| FBXL8 | PRAM1 | 0.761055 | 3 | 0 | 3 |
| FBXL8 | TMEM104 | 0.735209 | 3 | 0 | 3 |
| FBXL8 | C16orf91 | 0.733613 | 3 | 0 | 3 |
| FBXL8 | GPC2 | 0.711111 | 4 | 0 | 4 |
| FBXL8 | ADAMTS2 | 0.703869 | 4 | 0 | 3 |
| FBXL8 | ASB6 | 0.69224 | 4 | 0 | 3 |
| FBXL8 | PROC | 0.683374 | 3 | 0 | 3 |
| FBXL8 | GAS6-AS1 | 0.664235 | 3 | 0 | 3 |
| FBXL8 | E2F1 | 0.657031 | 3 | 0 | 3 |
| FBXL8 | LRRC46 | 0.654563 | 3 | 0 | 3 |
| FBXL8 | PPP1R3F | 0.645494 | 3 | 0 | 3 |
| FBXL8 | TXNL4B | 0.641449 | 3 | 0 | 3 |
| FBXL8 | POLD1 | 0.630233 | 3 | 0 | 3 |
| FBXL8 | GNL1 | 0.629605 | 5 | 0 | 4 |
| FBXL8 | ZDHHC8 | 0.628787 | 3 | 0 | 3 |
| FBXL8 | INSL4 | 0.627284 | 3 | 0 | 3 |
| FBXL8 | POU3F3 | 0.624724 | 4 | 0 | 3 |
| FBXL8 | BCL2L12 | 0.624571 | 3 | 0 | 3 |
| FBXL8 | ZNF524 | 0.623633 | 4 | 0 | 3 |
For details and further investigation, click here
