| Full name: ADAM metallopeptidase with thrombospondin type 1 motif 3 | Alias Symbol: KIAA0366|ADAMTS-4 | ||
| Type: protein-coding gene | Cytoband: 4q13.3 | ||
| Entrez ID: 9508 | HGNC ID: HGNC:219 | Ensembl Gene: ENSG00000156140 | OMIM ID: 605011 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAMTS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAMTS3 | 9508 | 214913_at | 0.9427 | 0.1205 | |
| GSE20347 | ADAMTS3 | 9508 | 214913_at | 0.0920 | 0.5392 | |
| GSE23400 | ADAMTS3 | 9508 | 214913_at | 0.0292 | 0.5903 | |
| GSE26886 | ADAMTS3 | 9508 | 214913_at | 0.7123 | 0.0043 | |
| GSE29001 | ADAMTS3 | 9508 | 214913_at | 0.1136 | 0.6976 | |
| GSE38129 | ADAMTS3 | 9508 | 214913_at | 0.1321 | 0.5083 | |
| GSE45670 | ADAMTS3 | 9508 | 214913_at | -0.0003 | 0.9995 | |
| GSE53622 | ADAMTS3 | 9508 | 35105 | 0.8521 | 0.0008 | |
| GSE53624 | ADAMTS3 | 9508 | 35105 | 0.9284 | 0.0000 | |
| GSE63941 | ADAMTS3 | 9508 | 214913_at | -3.9654 | 0.0000 | |
| GSE77861 | ADAMTS3 | 9508 | 214913_at | 0.0832 | 0.3796 | |
| SRP007169 | ADAMTS3 | 9508 | RNAseq | 2.7120 | 0.0214 | |
| SRP133303 | ADAMTS3 | 9508 | RNAseq | 0.8626 | 0.0153 | |
| SRP219564 | ADAMTS3 | 9508 | RNAseq | 0.7890 | 0.2066 | |
| TCGA | ADAMTS3 | 9508 | RNAseq | 0.0817 | 0.7914 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by ADAMTS3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAMTS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAMTS3 | 9508 | 1 | 10 | 19 | |
| GSE20123 | ADAMTS3 | 9508 | 1 | 10 | 19 | |
| GSE43470 | ADAMTS3 | 9508 | 0 | 13 | 30 | |
| GSE46452 | ADAMTS3 | 9508 | 2 | 35 | 22 | |
| GSE47630 | ADAMTS3 | 9508 | 1 | 19 | 20 | |
| GSE54993 | ADAMTS3 | 9508 | 7 | 0 | 63 | |
| GSE54994 | ADAMTS3 | 9508 | 1 | 9 | 43 | |
| GSE60625 | ADAMTS3 | 9508 | 0 | 0 | 11 | |
| GSE74703 | ADAMTS3 | 9508 | 0 | 11 | 25 | |
| GSE74704 | ADAMTS3 | 9508 | 1 | 5 | 14 | |
| TCGA | ADAMTS3 | 9508 | 21 | 25 | 50 |
Total number of gains: 35; Total number of losses: 137; Total Number of normals: 316.
Somatic mutations of ADAMTS3:
Generating mutation plots.
Highly correlated genes for ADAMTS3:
Showing top 20/350 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAMTS3 | SULT1E1 | 0.734075 | 4 | 0 | 3 |
| ADAMTS3 | PEAK1 | 0.694479 | 3 | 0 | 3 |
| ADAMTS3 | ARNT2 | 0.678642 | 8 | 0 | 7 |
| ADAMTS3 | SLC16A2 | 0.674186 | 3 | 0 | 3 |
| ADAMTS3 | AMDHD1 | 0.673447 | 3 | 0 | 3 |
| ADAMTS3 | SGIP1 | 0.669878 | 3 | 0 | 3 |
| ADAMTS3 | DNAH5 | 0.664621 | 3 | 0 | 3 |
| ADAMTS3 | BEX1 | 0.659424 | 5 | 0 | 4 |
| ADAMTS3 | TP53I13 | 0.659116 | 3 | 0 | 3 |
| ADAMTS3 | SUSD5 | 0.655786 | 5 | 0 | 5 |
| ADAMTS3 | MAK16 | 0.651839 | 3 | 0 | 3 |
| ADAMTS3 | LSAMP | 0.650444 | 5 | 0 | 3 |
| ADAMTS3 | FNDC1 | 0.643603 | 4 | 0 | 3 |
| ADAMTS3 | FBLN2 | 0.641943 | 4 | 0 | 3 |
| ADAMTS3 | RBP1 | 0.641121 | 3 | 0 | 3 |
| ADAMTS3 | GPC1 | 0.635336 | 3 | 0 | 3 |
| ADAMTS3 | NPTX2 | 0.63348 | 8 | 0 | 7 |
| ADAMTS3 | PTX3 | 0.632456 | 8 | 0 | 5 |
| ADAMTS3 | SLC39A1 | 0.62941 | 4 | 0 | 3 |
| ADAMTS3 | WTIP | 0.626708 | 5 | 0 | 5 |
For details and further investigation, click here
