| Full name: pentraxin 3 | Alias Symbol: TSG-14 | ||
| Type: protein-coding gene | Cytoband: 3q25.32 | ||
| Entrez ID: 5806 | HGNC ID: HGNC:9692 | Ensembl Gene: ENSG00000163661 | OMIM ID: 602492 |
| Drug and gene relationship at DGIdb | |||
Expression of PTX3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTX3 | 5806 | 206157_at | -0.4735 | 0.7731 | |
| GSE20347 | PTX3 | 5806 | 206157_at | 0.4309 | 0.1258 | |
| GSE23400 | PTX3 | 5806 | 206157_at | 0.1805 | 0.0446 | |
| GSE26886 | PTX3 | 5806 | 206157_at | 1.0267 | 0.0118 | |
| GSE29001 | PTX3 | 5806 | 206157_at | 1.6417 | 0.0286 | |
| GSE38129 | PTX3 | 5806 | 206157_at | 0.1916 | 0.6893 | |
| GSE45670 | PTX3 | 5806 | 206157_at | -1.5190 | 0.0562 | |
| GSE53622 | PTX3 | 5806 | 62033 | 0.1564 | 0.6563 | |
| GSE53624 | PTX3 | 5806 | 62033 | 0.4606 | 0.1052 | |
| GSE63941 | PTX3 | 5806 | 206157_at | -7.3146 | 0.0000 | |
| GSE77861 | PTX3 | 5806 | 206157_at | 0.0547 | 0.5731 | |
| GSE97050 | PTX3 | 5806 | A_23_P121064 | 0.3182 | 0.3274 | |
| SRP064894 | PTX3 | 5806 | RNAseq | -0.1316 | 0.8559 | |
| SRP133303 | PTX3 | 5806 | RNAseq | 0.1129 | 0.8518 | |
| SRP219564 | PTX3 | 5806 | RNAseq | -0.9847 | 0.3923 | |
| TCGA | PTX3 | 5806 | RNAseq | -0.8572 | 0.0369 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by PTX3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTX3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTX3 | 5806 | 21 | 1 | 8 | |
| GSE20123 | PTX3 | 5806 | 21 | 1 | 8 | |
| GSE43470 | PTX3 | 5806 | 23 | 0 | 20 | |
| GSE46452 | PTX3 | 5806 | 18 | 2 | 39 | |
| GSE47630 | PTX3 | 5806 | 18 | 4 | 18 | |
| GSE54993 | PTX3 | 5806 | 1 | 11 | 58 | |
| GSE54994 | PTX3 | 5806 | 38 | 1 | 14 | |
| GSE60625 | PTX3 | 5806 | 0 | 6 | 5 | |
| GSE74703 | PTX3 | 5806 | 20 | 0 | 16 | |
| GSE74704 | PTX3 | 5806 | 14 | 0 | 6 | |
| TCGA | PTX3 | 5806 | 75 | 1 | 20 |
Total number of gains: 249; Total number of losses: 27; Total Number of normals: 212.
Somatic mutations of PTX3:
Generating mutation plots.
Highly correlated genes for PTX3:
Showing top 20/440 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTX3 | GFRA1 | 0.719533 | 4 | 0 | 3 |
| PTX3 | C1QTNF1 | 0.712626 | 6 | 0 | 5 |
| PTX3 | CHSY3 | 0.709154 | 3 | 0 | 3 |
| PTX3 | CLEC11A | 0.707576 | 3 | 0 | 3 |
| PTX3 | FAP | 0.706966 | 5 | 0 | 5 |
| PTX3 | MAGI2-AS3 | 0.693814 | 3 | 0 | 3 |
| PTX3 | WNT2 | 0.686366 | 3 | 0 | 3 |
| PTX3 | KCND2 | 0.684972 | 3 | 0 | 3 |
| PTX3 | COL11A1 | 0.677588 | 3 | 0 | 3 |
| PTX3 | SLC14A1 | 0.675423 | 3 | 0 | 3 |
| PTX3 | SLIT3 | 0.675128 | 3 | 0 | 3 |
| PTX3 | DACT1 | 0.673553 | 9 | 0 | 7 |
| PTX3 | SDC2 | 0.670707 | 6 | 0 | 6 |
| PTX3 | STOML1 | 0.670398 | 3 | 0 | 3 |
| PTX3 | SCG5 | 0.668196 | 7 | 0 | 4 |
| PTX3 | C11orf96 | 0.667596 | 4 | 0 | 4 |
| PTX3 | NAGLU | 0.665237 | 3 | 0 | 3 |
| PTX3 | ST6GALNAC3 | 0.664261 | 4 | 0 | 3 |
| PTX3 | NAV1 | 0.660252 | 3 | 0 | 3 |
| PTX3 | HSD11B1 | 0.659073 | 6 | 0 | 5 |
For details and further investigation, click here
