| Full name: aryl hydrocarbon receptor nuclear translocator 2 | Alias Symbol: KIAA0307|bHLHe1 | ||
| Type: protein-coding gene | Cytoband: 15q25.1 | ||
| Entrez ID: 9915 | HGNC ID: HGNC:16876 | Ensembl Gene: ENSG00000172379 | OMIM ID: 606036 |
| Drug and gene relationship at DGIdb | |||
ARNT2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05211 | Renal cell carcinoma |
Expression of ARNT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARNT2 | 9915 | 202986_at | 0.0803 | 0.9460 | |
| GSE20347 | ARNT2 | 9915 | 202986_at | 0.4263 | 0.2011 | |
| GSE23400 | ARNT2 | 9915 | 202986_at | 0.0307 | 0.6772 | |
| GSE26886 | ARNT2 | 9915 | 202986_at | 1.5914 | 0.0009 | |
| GSE29001 | ARNT2 | 9915 | 202986_at | 0.2928 | 0.5661 | |
| GSE38129 | ARNT2 | 9915 | 202986_at | 0.2934 | 0.3570 | |
| GSE45670 | ARNT2 | 9915 | 202986_at | -0.0515 | 0.8788 | |
| GSE53622 | ARNT2 | 9915 | 8250 | 0.5279 | 0.0080 | |
| GSE53624 | ARNT2 | 9915 | 8250 | 0.4755 | 0.0004 | |
| GSE63941 | ARNT2 | 9915 | 202986_at | -2.4117 | 0.0101 | |
| GSE77861 | ARNT2 | 9915 | 202986_at | 0.5066 | 0.0206 | |
| GSE97050 | ARNT2 | 9915 | A_33_P3366195 | -0.1258 | 0.7966 | |
| SRP007169 | ARNT2 | 9915 | RNAseq | 1.1569 | 0.0702 | |
| SRP008496 | ARNT2 | 9915 | RNAseq | 2.1097 | 0.0007 | |
| SRP064894 | ARNT2 | 9915 | RNAseq | -0.0601 | 0.8280 | |
| SRP133303 | ARNT2 | 9915 | RNAseq | 1.0601 | 0.0001 | |
| SRP159526 | ARNT2 | 9915 | RNAseq | 2.4116 | 0.0005 | |
| SRP193095 | ARNT2 | 9915 | RNAseq | 0.5449 | 0.0465 | |
| SRP219564 | ARNT2 | 9915 | RNAseq | 0.8586 | 0.3205 | |
| TCGA | ARNT2 | 9915 | RNAseq | -0.2617 | 0.1727 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by ARNT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARNT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARNT2 | 9915 | 7 | 1 | 22 | |
| GSE20123 | ARNT2 | 9915 | 7 | 1 | 22 | |
| GSE43470 | ARNT2 | 9915 | 4 | 4 | 35 | |
| GSE46452 | ARNT2 | 9915 | 3 | 7 | 49 | |
| GSE47630 | ARNT2 | 9915 | 8 | 10 | 22 | |
| GSE54993 | ARNT2 | 9915 | 5 | 6 | 59 | |
| GSE54994 | ARNT2 | 9915 | 5 | 7 | 41 | |
| GSE60625 | ARNT2 | 9915 | 4 | 0 | 7 | |
| GSE74703 | ARNT2 | 9915 | 4 | 2 | 30 | |
| GSE74704 | ARNT2 | 9915 | 3 | 1 | 16 | |
| TCGA | ARNT2 | 9915 | 15 | 14 | 67 |
Total number of gains: 65; Total number of losses: 53; Total Number of normals: 370.
Somatic mutations of ARNT2:
Generating mutation plots.
Highly correlated genes for ARNT2:
Showing top 20/660 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARNT2 | NPTX2 | 0.773104 | 6 | 0 | 6 |
| ARNT2 | LAYN | 0.768453 | 3 | 0 | 3 |
| ARNT2 | CSN3 | 0.749335 | 3 | 0 | 3 |
| ARNT2 | ILDR2 | 0.717218 | 4 | 0 | 4 |
| ARNT2 | CYP2U1 | 0.713261 | 4 | 0 | 4 |
| ARNT2 | C4orf48 | 0.708479 | 3 | 0 | 3 |
| ARNT2 | NACC2 | 0.704596 | 3 | 0 | 3 |
| ARNT2 | LRRK1 | 0.702064 | 3 | 0 | 3 |
| ARNT2 | TSC22D1-AS1 | 0.688016 | 3 | 0 | 3 |
| ARNT2 | GPRC5C | 0.684755 | 4 | 0 | 4 |
| ARNT2 | CUX1 | 0.679445 | 3 | 0 | 3 |
| ARNT2 | ADAMTS3 | 0.678642 | 8 | 0 | 7 |
| ARNT2 | MYADM | 0.678622 | 3 | 0 | 3 |
| ARNT2 | FILIP1 | 0.675962 | 3 | 0 | 3 |
| ARNT2 | MAP9 | 0.671227 | 7 | 0 | 6 |
| ARNT2 | ANTXR2 | 0.670992 | 5 | 0 | 5 |
| ARNT2 | FGF3 | 0.670236 | 7 | 0 | 5 |
| ARNT2 | TMEM47 | 0.669939 | 4 | 0 | 4 |
| ARNT2 | CEP85L | 0.669656 | 3 | 0 | 3 |
| ARNT2 | PLEKHS1 | 0.667425 | 3 | 0 | 3 |
For details and further investigation, click here
